Fungistatic Activity and Identification of Antagonistic Actinomycetes to Camellia Disease from Soil

2010 ◽  
Author(s):  
Zhou Guoying ◽  
Song Guangtao ◽  
Yang Lei
Keyword(s):  
Fungistatic Activity ◽  
Antagonistic Actinomycetes

scholarly journals In Vitro Synergistic Interactions of Isavuconazole and Echinocandins against Candida auris

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 355
Author(s):  
Unai Caballero ◽  
Sarah Kim ◽  
Elena Eraso ◽  
Guillermo Quindós ◽  
Valvanera Vozmediano ◽  
...  
Keyword(s):  
Interaction Model ◽  
Antifungal Drugs ◽  
Health Concern ◽  
Candida Auris ◽  
Fungistatic Activity ◽  
Drug Concentrations ◽  
Low Concentrations ◽  
Wide Range ◽  
Time Kill

Candida auris is an emergent fungal pathogen that causes severe infectious outbreaks globally. The public health concern when dealing with this pathogen is mainly due to reduced susceptibility to current antifungal drugs. A valuable alternative to overcome this problem is to investigate the efficacy of combination therapy. The aim of this study was to determine the in vitro interactions of isavuconazole with echinocandins against C. auris. Interactions were determined using a checkerboard method, and absorbance data were analyzed with different approaches: the fractional inhibitory concentration index (FICI), Greco universal response surface approach, and Bliss interaction model. All models were in accordance and showed that combinations of isavuconazole with echinocandins resulted in an overall synergistic interaction. A wide range of concentrations within the therapeutic range were selected to perform time-kill curves. These confirmed that isavuconazole–echinocandin combinations were more effective than monotherapy regimens. Synergism and fungistatic activity were achieved with combinations that included isavuconazole in low concentrations (≥0.125 mg/L) and ≥1 mg/L of echinocandin. Time-kill curves revealed that once synergy was achieved, combinations of higher drug concentrations did not improve the antifungal activity. This work launches promising results regarding the combination of isavuconazole with echinocandins for the treatment of C. auris infections.

(2-Arylhydrazonomethyl)-substituted xanthones as antimycotics: synthesis and fungistatic activity against Candida species

2002 ◽  
Vol 37 (3) ◽  
pp. 237-253 ◽  
Author(s):  
Stéphane Moreau ◽  
Martine Varache-Lembège ◽  
Stéphane Larrouture ◽  
Djibril Fall ◽  
Arlette Neveu ◽  
...  
Keyword(s):  
Candida Species ◽  
Fungistatic Activity

ChemInform Abstract: EPC-Synthesis and Fungistatic Activity of a Gloeosporone Analogue with an ω-Hydroxybutyl Instead of the Pentyl Side Chain on the Macrocyclic Ring.

ChemInform ◽  
2010 ◽  
Vol 22 (2) ◽  
pp. no-no
Author(s):  
D. SEEBACH ◽  
G. ADAM ◽  
C. VON DEM BUSSCHE-HUENNEFELD ◽  
U. GISI ◽  
H. BINDER
Keyword(s):  
Side Chain ◽  
Macrocyclic Ring ◽  
Fungistatic Activity

Antifungal activity of dermadex-agents for the treatment of microsporia and trichophytia

2001 ◽  
Vol 82 (3) ◽  
pp. 214-214
Author(s):  
L. R. Zakieva ◽  
R. S. Garaev ◽  
M. T. Tremasov
Keyword(s):  
Antifungal Activity ◽  
Antifungal Agent ◽  
Medicinal Form ◽  
Toxicological Evaluation ◽  
Fungistatic Activity

The aim of our study was the toxicological evaluation of the drug Dermadex, which is a new medicinal form of the antifungal agent 2-mercantobenzothiazole, as well as the study of its fungicidal and fungistatic activity with the development of tactics for the treatment of microsporia and trichophytia.

Synthesis and Antimicrobial, Antiprotozoal, and Fungistatic Activity of [5-(Amino-, Acylamino-, and 2-Pyridylmethylamino)-1-Alkylbenzimidazol-2-yl]Diphenylmethanols

2018 ◽  
Vol 52 (8) ◽  
pp. 711-715 ◽  
Author(s):  
Yu. V. Koshchienko ◽  
Yu. D. Drobin ◽  
A. A. Zubenko ◽  
D. A. Timoshevskii ◽  
L. N. Fetisov ◽  
...  
Keyword(s):  
Fungistatic Activity

Fungistatic Activity of Engineered Nanoparticles

2018 ◽  
Vol 13 (5-6) ◽  
pp. 277-280 ◽  
Author(s):  
A. A. Asanova ◽  
V. I. Polonskiy ◽  
N. S. Manukovsky ◽  
S. V. Khizhnyak
Keyword(s):  
Engineered Nanoparticles ◽  
Fungistatic Activity

scholarly journals Antifungal activities of thiosemicarbazones and semicarbazones against mycotoxigenic fungi

2014 ◽  
Vol 38 (6) ◽  
pp. 531-537 ◽  
Author(s):  
Rojane de Oliveira Paiva ◽  
Lucimar Ferreira Kneipp ◽  
Carla Marins Goular ◽  
Mariana Almeida Albuquerque ◽  
Aurea Echevarria
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Flavus ◽  
Fungicidal Activity ◽  
Fusarium Verticillioides ◽  
Animal Health ◽  
Fungistatic Activity ◽  
Mycotoxigenic Fungi ◽  
Quality Of Food ◽  
Chelating Effect

Mycotoxigenic fungi can compromise the quality of food, exposing human and animal health at risk. The antifungal activity of eight thiosemicarbazones (1-8) and nine semicarbazones (9-17) was evaluated against Aspergillus flavus, A. nomius, A. ochraceus, A. parasiticus and Fusarium verticillioides. Thiosemicarbazones had MIC values of 125-500 µg/ml. The thiosemicarbazones 1 and 2 exerted fungistatic activity against Aspergillus spp., and thiosemicarbazone 2 exerted fungicidal activity against F. verticillioides. Compound 2 showed an iron chelating effect of 63%. The ergosterol content of A. parasiticus had a decrease of 28 and 71% for the 31.2 and 62.5 µg/ml concentrations of thiosemicarbazone 2 compared to the control. The obtained results of antifungal activity revealed that thiosemicarbazone class was more active when compared to semicarbazone class and, the thiosemicarbazone 2 was the most active compound, specially, against Aspergillus spp.

scholarly journals The role of exochitinase type A1 in the fungistatic activity of the rhizosphere bacterium Paenibacillus sp. M4

2016 ◽  
Vol 68 (2) ◽  
pp. 451-459
Author(s):  
Urszula Jankiewicz ◽  
Maria Swiontek-Brzezinska
Keyword(s):  
Plant Pathogens ◽  
Chitinase Activity ◽  
Maximum Activity ◽  
Synergistic Action ◽  
Chitinolytic Activity ◽  
Fungistatic Activity ◽  
Rhizosphere Bacterium ◽  
Paenibacillus Sp ◽  
Growth Inhibiting

The aim of the study was to detect the activity and characterize potentially fungistatic chitinases synthesized by rhizosphere bacteria identified as Paenibacillus sp. M4. Maximum chitinolytic activity was achieved on the fifth day of culturing bacteria in a growth medium with 1% colloidal chitin. Analysis of a zymogram uncovered the presence of four activity bands in the crude bacterial extract. The used three-stage protein purification procedure resulted in a single band of chitinase activity on the zymogram. The purified enzyme exhibited maximum activity at pH 6.5 and temperature 45oC, and thermal stability at 40oC for 4 h. In terms of substrate specificity, it is an exochitinase (chitobiose). The amino acid sequence obtained after mass spectrometry showed similarity to chitinase A1 synthesized by Bacillus circulans. The M4 isolate demonstrated the highest growth inhibiting activity against plant pathogens belonging to the genera Fusarium, Rhizoctonia and Alternaria. Fungistatic activity, although to a somewhat lesser degree, was also demonstrated by purified chitinase. The obtained results confirm the participation of the studied exochitinase in antagonism towards pathogenic molds. However, the lower fungistatic effectiveness of the chitinases points to the synergistic action of different metabolites in biocontrol by these bacteria.

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