Neutral space analysis of gene regulatory network models of salt stress response in Arabidopsis using evolutionary computation

2016 ◽  
Author(s):  
Gonzalo A. Ruz ◽  
Tania Timmermann ◽  
Eric Goles
Keyword(s):  
Salt Stress ◽  
Stress Response ◽  
Evolutionary Computation ◽  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Network Models ◽  
Salt Stress Response ◽  
Space Analysis ◽  
Neutral Space ◽  
Gene Regulatory

scholarly journals Gene regulatory network models in response to sugars in the plant circadian system

2018 ◽  
Vol 457 ◽  
pp. 137-151 ◽  
Author(s):  
Takayuki Ohara ◽  
Timothy J. Hearn ◽  
Alex A.R. Webb ◽  
Akiko Satake
Keyword(s):  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Network Models ◽  
Circadian System ◽  
Gene Regulatory

Inferring Gene Regulatory Network Models from Time-Series Data Using Metaheuristics

2020 ◽  
Author(s):  
Jose Eduardo H. da Silva ◽  
Heder S. Betnardino ◽  
Helio J.C. Barbosa ◽  
Alex B. Vieira ◽  
Luciana C.D. Campos ◽  
...  
Keyword(s):  
Time Series ◽  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Time Series Data ◽  
Network Models ◽  
Series Data ◽  
Gene Regulatory

Multi-level gene regulatory network models to understand complex mechanisms underlying plant development

2020 ◽  
Vol 57 ◽  
pp. 171-179
Author(s):  
Mónica L García-Gómez ◽  
Aaron Castillo-Jiménez ◽  
Juan Carlos Martínez-García ◽  
Elena R Álvarez-Buylla
Keyword(s):  
Gene Regulatory Network ◽  
Plant Development ◽  
Regulatory Network ◽  
Network Models ◽  
Multi Level ◽  
Gene Regulatory ◽  
Complex Mechanisms

Evolutionarily conserved hierarchical gene regulatory networks for plant salt stress response

Nature Plants ◽  
2021 ◽  
Author(s):  
Ting-Ying Wu ◽  
HonZhen Goh ◽  
Christina B. Azodi ◽  
Shalini Krishnamoorthi ◽  
Ming-Jung Liu ◽  
...  
Keyword(s):  
Salt Stress ◽  
Stress Response ◽  
Gene Regulatory Networks ◽  
Regulatory Networks ◽  
Salt Stress Response ◽  
Evolutionarily Conserved ◽  
Gene Regulatory

scholarly journals GRAND: a database of gene regulatory network models across human conditions

2021 ◽  
Author(s):  
Marouen Ben Guebila ◽  
Camila M Lopes-Ramos ◽  
Deborah Weighill ◽  
Abhijeet Rajendra Sonawane ◽  
Rebekka Burkholz ◽  
...  
Keyword(s):  
Gene Regulatory Network ◽  
Small Molecule ◽  
Regulatory Network ◽  
Web Application ◽  
Target Genes ◽  
Network Models ◽  
Response To Therapy ◽  
Specific Gene ◽  
Phenotypic Information ◽  
Gene Regulatory

Abstract Gene regulation plays a fundamental role in shaping tissue identity, function, and response to perturbation. Regulatory processes are controlled by complex networks of interacting elements, including transcription factors, miRNAs and their target genes. The structure of these networks helps to determine phenotypes and can ultimately influence the development of disease or response to therapy. We developed GRAND (https://grand.networkmedicine.org) as a database for computationally-inferred, context-specific gene regulatory network models that can be compared between biological states, or used to predict which drugs produce changes in regulatory network structure. The database includes 12 468 genome-scale networks covering 36 human tissues, 28 cancers, 1378 unperturbed cell lines, as well as 173 013 TF and gene targeting scores for 2858 small molecule-induced cell line perturbation paired with phenotypic information. GRAND allows the networks to be queried using phenotypic information and visualized using a variety of interactive tools. In addition, it includes a web application that matches disease states to potentially therapeutic small molecule drugs using regulatory network properties.

Sign in / Sign up

Export Citation Format

Share Document