Uncertainty Modelling and Stability Robustness Analysis of Nucleic Acid-Based Feedback Control Systems

2018 ◽  
Author(s):  
Nuno M.G. Paulino ◽  
Mathie Foo ◽  
Jongmin Kim ◽  
Declan Bates
Keyword(s):  
Nucleic Acid ◽  
Feedback Control ◽  
Control Systems ◽  
Robustness Analysis ◽  
Uncertainty Modelling ◽  
Stability Robustness ◽  
Feedback Control Systems

scholarly journals Minimally Complex Nucleic Acid Feedback Control Systems for First Experimental Implementations

2020 ◽  
Vol 53 (2) ◽  
pp. 16745-16752
Author(s):  
Nuno M.G. Paulino ◽  
Mathias Foo ◽  
Tom F.A. de Greef ◽  
Jongmin Kim ◽  
Declan G. Bates
Keyword(s):  
Nucleic Acid ◽  
Feedback Control ◽  
Control Systems ◽  
Feedback Control Systems

On the stability of nucleic acid feedback control systems

Automatica ◽  
2020 ◽  
Vol 119 ◽  
pp. 109103
Author(s):  
Nuno Miguel Gomes Paulino ◽  
Mathias Foo ◽  
Jongmin Kim ◽  
Declan G. Bates
Keyword(s):  
Nucleic Acid ◽  
Feedback Control ◽  
Control Systems ◽  
Feedback Control Systems ◽  
The Stability

scholarly journals Minimally Complex Nucleic Acid Feedback Control Systems for First Experimental Implementations

2019 ◽  
Author(s):  
Nuno M. G. Paulino ◽  
Mathias Foo ◽  
Tom F. A. de Greef ◽  
Jongmin Kim ◽  
Declan G. Bates
Keyword(s):  
Nucleic Acid ◽  
Feedback Control ◽  
Control Systems ◽  
Scale Up ◽  
Building Blocks ◽  
State Feedback Control ◽  
Dna Strand Displacement ◽  
Feedback Control Systems ◽  
Control Circuits ◽  
Dna Strand

AbstractChemical reaction networks based on catalysis, degradation, and annihilation may be used as building blocks to construct a variety of dynamical and feedback control systems in Synthetic Biology. DNA strand-displacement, which is based on DNA hybridisation programmed using Watson-Crick base pairing, is an effective primitive to implement such reactions experimentally. However, experimental construction, validation and scale-up of nucleic acid control systems is still significantly lagging theoretical developments, due to several technical challenges, such as leakage, crosstalk, and toehold sequence design. To help the progress towards experimental implementation, we provide here designs representing two fundamental classes of reference tracking control circuits (integral and state-feedback control), for which the complexity of the chemical reactions required for implementation has been minimised. The supplied ‘minimally complex’ control circuits should be ideal candidates for first experimental validations of nucleic acid controllers.

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