Identification of time-varying linear models

Author(s):  
R. Lozano
Keyword(s):  
Author(s):  
Ronald K. Pearson

It was emphasized in Chapter 1 that low-order, linear time-invariant models provide the foundation for much intuition about dynamic phenomena in the real world. This chapter provides a brief review of the characteristics and behavior of linear models, beginning with these simple cases and then progressing to more complex examples where this intuition no longer holds: infinite-dimensional and time-varying linear models. In continuous time, infinite-dimensional linear models arise naturally from linear partial differential equations whereas in discrete time, infinite-dimensional linear models may be used to represent a variety of “slow decay” effects. Time-varying linear models are also extremely flexible: In the continuous-time case, many of the ordinary differential equations defining special functions (e.g., the equations defining Bessel functions) may be viewed as time-varying linear models; in the discrete case, the gamma function arises naturally as the solution of a time-varying difference equation. Sec. 2.1 gives a brief discussion of low-order, time-invariant linear dynamic models, using second-order examples to illustrate both the “typical” and “less typical” behavior that is possible for these models. One of the most powerful results of linear system theory is that any time-invariant linear dynamic system may be represented as either a moving average (i.e., convolution-type) model or an autoregressive one. Sec. 2.2 presents a short review of these ideas, which will serve to establish both notation and a certain amount of useful intuition for the discussion of NARMAX models presented in Chapter 4. Sec. 2.3 then briefly considers the problem of characterizing linear models, introducing four standard input sequences that are typical of those used in linear model characterization. These standard sequences are then used in subsequent chapters to illustrate differences between nonlinear model behavior and linear model behavior. Sec. 2.4 provides a brief introduction to infinite-dimensional linear systems, including both continuous-time and discrete-time examples. Sec. 2.5 provides a similar introduction to the subject of time-varying linear systems, emphasizing the flexibility of this class. Finally, Sec. 2.6 briefly considers the nature of linearity, presenting some results that may be used to define useful classes of nonlinear models.


Heliyon ◽  
2017 ◽  
Vol 3 (7) ◽  
pp. e00340
Author(s):  
Jeff M. Byers ◽  
Joseph A. Christodoulides ◽  
James B. Delehanty ◽  
Deepa Raghu ◽  
Marc P. Raphael

Biostatistics ◽  
2019 ◽  
Author(s):  
Luis F Campos ◽  
Mark E Glickman ◽  
Kristen B Hunter

Summary One of the most significant barriers to medication treatment is patients’ non-adherence to a prescribed medication regimen. The extent of the impact of poor adherence on resulting health measures is often unknown, and typical analyses ignore the time-varying nature of adherence. This article develops a modeling framework for longitudinally recorded health measures modeled as a function of time-varying medication adherence. Our framework, which relies on normal Bayesian dynamic linear models (DLMs), accounts for time-varying covariates such as adherence and non-dynamic covariates such as baseline health characteristics. Standard inferential procedures for DLMs are inefficient when faced with infrequent and irregularly recorded response data. We develop an approach that relies on factoring the posterior density into a product of two terms: a marginal posterior density for the non-dynamic parameters, and a multivariate normal posterior density of the dynamic parameters conditional on the non-dynamic ones. This factorization leads to a two-stage process for inference in which the non-dynamic parameters can be inferred separately from the time-varying parameters. We demonstrate the application of this model to the time-varying effect of antihypertensive medication on blood pressure levels for a cohort of patients diagnosed with hypertension. Our model results are compared to ones in which adherence is incorporated through non-dynamic summaries.


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