Genetic algorithm based weighted extreme learning machine for binary imbalance learning

Author(s):  
Rudranshu Sharma ◽  
Ankur Singh Bist
Author(s):  
Kai Hu ◽  
Zhaodi Zhou ◽  
Liguo Weng ◽  
Jia Liu ◽  
Lihua Wang ◽  
...  

Machine learning is a subfield of artificial intelligence concerned with techniques that allow computers to improve their outputs based on previous experiences. Among numerous machine learning algorithms, Weighted Extreme Learning Machine (WELM) is one of the famous cases recently. It not only has Extreme Learning Machine (ELM)’s extremely fast training speed and better generalization performance than traditional Neuron Network (NN), but also has the merit in handling imbalance data by assigning more weight to minority class and less weight to majority class. But it still has the limitation of its weight generated according to class distribution of training data, thereby, creating dependency on input data [R. Sharma and A. S. Bist, Genetic algorithm based weighted extreme learning machine for binary imbalance learning, 2015 Int. Conf. Cognitive Computing and Information Processing (CCIP) (IEEE, 2015), pp. 1–6; N. Koutsouleris, Classification/machine learning approaches, Annu. Rev. Clin. Psychol. 13(1) (2016); G. Dudek, Extreme learning machine for function approximation–interval problem of input weights and biases, 2015 IEEE 2nd Int. Conf. Cybernetics (CYBCONF) (IEEE, 2015), pp. 62–67; N. Zhang, Y. Qu and A. Deng, Evolutionary extreme learning machine based weighted nearest-neighbor equality classification, 2015 7th Int. Conf. Intelligent Human-Machine Systems and Cybernetics (IHMSC), Vol. 2 (IEEE, 2015), pp. 274–279]. This leads to the lack of finding optimal weight at which good generalization performance could be achieved [R. Sharma and A. S. Bist, Genetic algorithm based weighted extreme learning machine for binary imbalance learning, 2015 Int. Conf. Cognitive Computing and Information Processing (CCIP) (IEEE, 2015), pp. 1–6; N. Koutsouleris, Classification/machine learning approaches, Annu. Rev. Clin. Psychol. 13(1) (2016); G. Dudek, Extreme learning machine for function approximation–interval problem of input weights and biases, 2015 IEEE 2nd Int. Conf. Cybernetics (CYBCONF) (IEEE, 2015), pp. 62–67; N. Zhang, Y. Qu and A. Deng, Evolutionary extreme learning machine based weighted nearest-neighbor equality classification, 2015 7th Int. Conf. Intelligent Human-Machine Systems and Cybernetics (IHMSC), Vol. 2 (IEEE, 2015), pp. 274–279]. To solve it, a hybrid algorithm which composed by WELM algorithm and Particle Swarm Optimization (PSO) is proposed. Firstly, it distributes the weight according to the number of different samples, determines weighted method; Then, it combines the ELM model and the weighted method to establish WELM model; finally it utilizes PSO to optimize WELM’s three parameters (input weight, bias, the weight of imbalanced training data). Experiment data from both prediction and recognition show that it has better performance than classical WELM algorithms.


2013 ◽  
Vol 101 ◽  
pp. 229-242 ◽  
Author(s):  
Weiwei Zong ◽  
Guang-Bin Huang ◽  
Yiqiang Chen

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Ji-Yong An ◽  
Fan-Rong Meng ◽  
Zi-Ji Yan

Abstract Background Prediction of novel Drug–Target interactions (DTIs) plays an important role in discovering new drug candidates and finding new proteins to target. In consideration of the time-consuming and expensive of experimental methods. Therefore, it is a challenging task that how to develop efficient computational approaches for the accurate predicting potential associations between drug and target. Results In the paper, we proposed a novel computational method called WELM-SURF based on drug fingerprints and protein evolutionary information for identifying DTIs. More specifically, for exploiting protein sequence feature, Position Specific Scoring Matrix (PSSM) is applied to capturing protein evolutionary information and Speed up robot features (SURF) is employed to extract sequence key feature from PSSM. For drug fingerprints, the chemical structure of molecular substructure fingerprints was used to represent drug as feature vector. Take account of the advantage that the Weighted Extreme Learning Machine (WELM) has short training time, good generalization ability, and most importantly ability to efficiently execute classification by optimizing the loss function of weight matrix. Therefore, the WELM classifier is used to carry out classification based on extracted features for predicting DTIs. The performance of the WELM-SURF model was evaluated by experimental validations on enzyme, ion channel, GPCRs and nuclear receptor datasets by using fivefold cross-validation test. The WELM-SURF obtained average accuracies of 93.54, 90.58, 85.43 and 77.45% on enzyme, ion channels, GPCRs and nuclear receptor dataset respectively. We also compared our performance with the Extreme Learning Machine (ELM), the state-of-the-art Support Vector Machine (SVM) on enzyme and ion channels dataset and other exiting methods on four datasets. By comparing with experimental results, the performance of WELM-SURF is significantly better than that of ELM, SVM and other previous methods in the domain. Conclusion The results demonstrated that the proposed WELM-SURF model is competent for predicting DTIs with high accuracy and robustness. It is anticipated that the WELM-SURF method is a useful computational tool to facilitate widely bioinformatics studies related to DTIs prediction.


2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Derya Avci ◽  
Akif Dogantekin

Parkinson disease is a major public health problem all around the world. This paper proposes an expert disease diagnosis system for Parkinson disease based on genetic algorithm- (GA-) wavelet kernel- (WK-) Extreme Learning Machines (ELM). The classifier used in this paper is single layer neural network (SLNN) and it is trained by the ELM learning method. The Parkinson disease datasets are obtained from the UCI machine learning database. In wavelet kernel-Extreme Learning Machine (WK-ELM) structure, there are three adjustable parameters of wavelet kernel. These parameters and the numbers of hidden neurons play a major role in the performance of ELM. In this study, the optimum values of these parameters and the numbers of hidden neurons of ELM were obtained by using a genetic algorithm (GA). The performance of the proposed GA-WK-ELM method is evaluated using statical methods such as classification accuracy, sensitivity and specificity analysis, and ROC curves. The calculated highest classification accuracy of the proposed GA-WK-ELM method is found as 96.81%.


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