Stability analysis of sampled-data system with application to control of International Space Station

2002 ◽  
Author(s):  
A. Tchernychev ◽  
T. Alt
Keyword(s):  
Stability Analysis ◽  
International Space Station ◽  
Space Station ◽  
Data System ◽  
Sampled Data ◽  
International Space

Human factors assessment of International Space Station (ISS) medical equipment packs

2005 ◽  
Author(s):  
Danielle Paige Smith ◽  
Vicky E. Byrne ◽  
Cynthia Hudy ◽  
Mihriban Whitmore
Keyword(s):  
Human Factors ◽  
International Space Station ◽  
Medical Equipment ◽  
Space Station ◽  
International Space

Dose Tracker Application for Collecting Medication Use Data from International Space Station Crew

2020 ◽  
Vol 91 (1) ◽  
pp. 41-45 ◽  
Author(s):  
Virginia. E. Wotring ◽  
LaRona K. Smith
Keyword(s):  
Data Collection ◽  
International Space Station ◽  
Sleep Disturbances ◽  
Space Station ◽  
Medication Use ◽  
International Space ◽  
Flight Data ◽  
Open Questions ◽  
Share Data ◽  
Usability Feedback

INTRODUCTION: There are knowledge gaps in spaceflight pharmacology with insufficient in-flight data to inform future planning. This effort directly addressed in-mission medication use and also informed open questions regarding spaceflight-associated changes in pharmacokinetics (PK) and/or pharmacodynamics (PD).METHODS: An iOS application was designed to collect medication use information relevant for research from volunteer astronaut crewmembers: medication name, dose, dosing frequency, indication, perceived efficacy, and side effects. Leveraging the limited medication choices aboard allowed a streamlined questionnaire. There were 24 subjects approved for participation.RESULTS: Six crewmembers completed flight data collection and five completed ground data collection before NASA’s early study discontinuation. There were 5766 medication use entries, averaging 20.6 ± 8.4 entries per subject per flight week. Types of medications and their indications were similar to previous reports, with sleep disturbances and muscle/joint pain as primary drivers. Two subjects treated prolonged skin problems. Subjects also used the application in unanticipated ways: to note drug tolerance testing or medication holiday per research protocols, and to share data with flight surgeons. Subjects also provided usability feedback on application design and implementation.DISCUSSION: The volume of data collected (20.6 ± 8.4 entries per subject per flight week) is much greater than was collected previously (<12 per person per entire mission), despite user criticisms regarding app usability. It seems likely that improvements in a software-based questionnaire application could result in a robust data collection tool that astronauts find more acceptable, while simultaneously providing researchers and clinicians with useful data.Wotring VE, Smith LK. Dose tracker application for collecting medication use data from International Space Station crew. Aerosp Med Hum Perform. 2020; 91(1):41–45.

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