Selection of Target Area for Interventional and Cell Therapy after Myocardial Infarction Using 3d Echocardiography

2008 ◽  
Author(s):  
Claudia Matei ◽  
Theodora Benedek ◽  
Monica Chitu ◽  
Istvan Benedek Jr. ◽  
I. A. Sarbu-Pop ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cell Therapy ◽  
3D Echocardiography ◽  
Target Area ◽  
Selection Of

scholarly journals Central zone of myocardial infarction: a neglected target area for heart cell therapy

2012 ◽  
Vol 16 (3) ◽  
pp. 636-647 ◽  
Author(s):  
Peifeng Jin ◽  
Enshi Wang ◽  
Ye-huan Wang ◽  
Weicong Huang ◽  
Wenan Kuang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cell Therapy ◽  
Central Zone ◽  
Heart Cell ◽  
Target Area

ST-elevation myocardial infarction complicated by cardiac arrest in a young patient with familiar dyslipidemia

2021 ◽  
Vol 148 (12) ◽  
pp. 141-145
Author(s):  
Pham Minh Tuan ◽  
Doan Tuan Vu
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Arrest ◽  
Stem Cell ◽  
Cell Therapy ◽  
Young Patient ◽  
Stem Cell Therapy ◽  
St Elevation Myocardial Infarction ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
St Elevation

Coronary heart disease in young patients always poses great challenges for every healthcare system with differences in clinical manifestations, etiology, epidemiology, angiographic characteristics and prognosis. The objective of this study was to describe a case of ST-elevation myocardial infarction complicated by cardiac arrest in a young patient with familial dyslipidemia. A 30-year-old male visited our hospital with typical angina. During the examination, he suffered a sudden loss of consciousness, the monitor showed ventricular fibrillation. After successful resuscitation of cardiac arrest, electrocardiography showed apparent ST-elevation from V2 to V6 leads consistent with the diagnosis of anterolateral infarction. Emergency coronary angiogram showed severe three-vessel lesions including complete occlusion of the LAD artery and 80 - 90% stenosis of the other two coronary branches. Our patient’s coronary arteries were revascularized using drug-eluting stents in LAD artery and subsequently RCA artery, stem cell therapy was applied during the interventional process. Routine laboratory test results showed dyslipidemia and his family records suggested familiar (hereditary) dyslipidemia which affected his mother and sister. 1-month follow-up echocardiography showed a drastic improvement of LVEF by roughly 15%. The combination of revascularization, stem cell therapy, and lipid-lowering therapy has shown a good therapeutic effect.

scholarly journals The unique mechanism of functional mitral regurgitation in acute myocardial infarction: a prospective dynamic 4D quantitative echocardiographic study

2018 ◽  
Vol 20 (4) ◽  
pp. 396-406 ◽  
Author(s):  
Toshiyuki Kimura ◽  
Véronique L Roger ◽  
Nozomi Watanabe ◽  
Sergio Barros-Gomes ◽  
Yan Topilsky ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Mitral Regurgitation ◽  
Regional Wall Motion ◽  
Sudden Onset ◽  
Left Ventricular ◽  
3D Echocardiography ◽  
Functional Mitral Regurgitation ◽  
Acute Mi ◽  
Mitral Apparatus

Abstract Aims Mechanisms of chronic ischaemic mitral regurgitation (IMR) are well-characterized by apically tethered leaflet caused by papillary muscles (PMs) displacement and adynamic mitral apparatus. We investigated the unique geometry and dynamics of the mitral apparatus in first acute myocardial infarction (MI) by using quantified 3D echocardiography. Methods and results We prospectively performed 3D echocardiography 2.3 ± 1.8 days after first MI, in 174 matched patients with (n = 87) and without IMR (n = 87). 3D echocardiography of left ventricular (LV) volumes and of mitral apparatus dynamics throughout cardiac cycle was quantified. Similar mitral quantification was obtained at chronic post-MI stage (n = 44). Mechanistically, acute IMR was associated with larger and flatter annulus (area 9.29 ± 1.74 cm2 vs. 8.57 ± 1.94 cm2, P = 0.002, saddle shape 12.7 ± 4.5% vs. 15.0 ± 4.6%, P = 0.001), and larger tenting (length 6.36 ± 1.78 mm vs. 5.60 ± 1.55 mm, P = 0.003) but vs. chronic MI, mitral apparatus displayed smaller alterations (all P < 0.01) and annular size, PM movement remained dynamic (all P < 0.01). Specific to acute IMR, without PM apical displacement (P > 0.70), greater separation (21.7 ± 4.9 mm vs. 20.0 ± 3.4 mm, P = 0.01), and widest angulation of PM (38.4 ± 6.2° for moderate vs. 33.5 ± 7.3° for mild vs. 31.4 ± 6.3° for no-IMR, P = 0.0009) wider vs. chronic MI (P < 0.01). Conclusions 3D echocardiography of patients with first MI provides insights into unique 4D dynamics of the mitral apparatus in acute IMR. Mitral apparatus remained dynamic in acute MI and distinct IMR mechanism in acute MI is not PM displacement seen in chronic IMR but separation and excess angulation of PM deforming the mitral valve, probably because of sudden-onset regional wall motion abnormality without apparent global LV remodelling. This specific mechanism should be considered in novel therapeutic strategies for IMR complicating acute MI.

Cell Therapy of Acute Myocardial Infarction: Open Questions

Cardiology ◽  
2008 ◽  
Vol 113 (3) ◽  
pp. 155-160 ◽  
Author(s):  
Stefanie Dimmeler ◽  
Andreas M. Zeiher
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cell Therapy ◽  
Open Questions

scholarly journals Myocardial infarction models in NOD/Scid mice for cell therapy research: permanent ischemia vs ischemia–reperfusion

SpringerPlus ◽  
2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Vanessa-Leigh van Zuylen ◽  
Melina C den Haan ◽  
Helene Roelofs ◽  
Willem E Fibbe ◽  
Martin J Schalij ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cell Therapy ◽  
Ischemia Reperfusion ◽  
Scid Mice

Optimizing Stem Cell Therapy for Cardiac Repair Following a Myocardial Infarction

2013 ◽  
pp. 513-524
Author(s):  
Kaustabh Singh ◽  
Keith R. Brunt ◽  
Richard D. Weisel ◽  
Ren-Ke Li
Keyword(s):  
Myocardial Infarction ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Cardiac Repair
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