Association of APOE and other genetic polymorphisms with prospective concussion risk in a prospective cohort study of college athletes

2014 ◽  
Author(s):  
Thomas R. Terrell ◽  
Roberd Bostick ◽  
Gary L. Rogers ◽  
Michael A. Langston ◽  
Jeffery Barth ◽  
...  
Keyword(s):  
Cohort Study ◽  
Genetic Polymorphisms ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
College Athletes

Genetic polymorphisms associated with the risk of concussion in 1056 college athletes: a multicentre prospective cohort study

2017 ◽  
Vol 52 (3) ◽  
pp. 192-198 ◽  
Author(s):  
Thomas Roland Terrell ◽  
Ruth Abramson ◽  
Jeffery T Barth ◽  
Ellen Bennett ◽  
Robert C Cantu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Genetic Polymorphisms ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
College Athletes ◽  
Positive Association ◽  
American Football ◽  
Study Cohort ◽  
Significant Positive Association ◽  
Adjusted Logistic Regression

Background/aimTo evaluate the association of genetic polymorphisms APOE, APOE G-219T promoter, microtubule associated protein(MAPT)/tau exon 6 Ser53Pro, MAPT/tau Hist47Tyr, IL-6572 G/C and IL-6RAsp358Ala with the risk of concussion in college athletes.MethodsA 23-centre prospective cohort study of 1056 college athletes with genotyping was completed between August 2003 and December 2012. All athletes completed baseline medical and concussion questionnaires, and post-concussion data were collected for athletes with a documented concussion.ResultsThe study cohort consisted of 1056 athletes of mean±SD age 19.7±1.5 years, 89.3% male, 59.4% Caucasian, 35.0% African-American, 5.6% other race. The athletes participated in American football, soccer, basketball, softball, men’s wrestling and club rugby. A total of 133 (12.1% prevalence) concussions occurred during an average surveillance of 3 years per athlete. We observed a significant positive association between IL-6R CC (p=0.001) and a negative association between APOE4 (p=0.03) and the risk of concussion. Unadjusted and adjusted logistic regression analysis showed a significant association between IL-6R CC and concussion (OR 3.48; 95% CI 1.58 to 7.65; p=0.002) and between the APOE4 allele and concussion (OR 0.61; 95% CI 0.38 to 0.96; p=0.04), which persisted after adjustment for confounders.ConclusionsIL-6R CC was associated with a three times greater concussion risk and APOE4 with a 40% lower risk.

scholarly journals Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study

2007 ◽  
Vol 3 (1) ◽  
pp. 22 ◽  
Author(s):  
Thanh GN Ton ◽  
Mary Rossing ◽  
Deborah J Bowen ◽  
Sengkeo Srinouanprachan ◽  
Kristine Wicklund ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Cohort Study ◽  
Genetic Polymorphisms ◽  
Prospective Cohort Study ◽  
Prospective Cohort

Organizational Justice and Health of Employees: Prospective Cohort Study.

2013 ◽  
Author(s):  
Mika Kivimaki ◽  
Marko Elovainio ◽  
Jussi Vahtera ◽  
Marianna Virtanen ◽  
Jane E. Ferrie
Keyword(s):  
Cohort Study ◽  
Organizational Justice ◽  
Prospective Cohort Study ◽  
Prospective Cohort
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