On-chip cell separation and manipulation using traveling wave dielectrophoretic force controlled by four-phase signal generator

Author(s):  
Kata Jaruwongrangsee ◽  
Thitima Maturos ◽  
Sakshin Bunthawin ◽  
Anurat Wisitsoraat ◽  
Manas Sangworasil ◽  
...  
Author(s):  
Alejandro Márquez Marzal ◽  
Nicolás Medrano Marqués ◽  
Belén Calvo López ◽  
Pedro A. Martínez Martínez

A CMOS fully integrated quadrature signal generator for on-chip impedance spectroscopy (IS) applications is presented. Frequency can be digitally tuned from 5 to 350 kHz with 12-bit resolution. Power consumption is 0.77 mW and active area is 0.129 mm2. Its suitability for the target application is validated with a Randles test impedance cell modelling a protein.


Author(s):  
Sophie Loire ◽  
Igor Mezic

Joint effect of traveling wave dielectrophoresis and AC electroosmotic fluid flow is used to sort bacteria from other particles and increase the bacteria output concentration in a microfluidic device. The device consists of a thin and long rectangular channel with two interdigitated electrode arrays, one at the bottom and one at the top of the channel, that are used to generate a nonuniform electric field. A four-phase signal at high frequency superposed on a low frequency signal is applied. At the end of the channel, the fluid is collected in two outputs: the bacteria are collected on one side and fluid without bacteria is collected on the other side. We have previously demonstrated a method to optimize cell separation using multiple frequency dielectrophoresis. The device presented here illustrates a novel use of multiple frequencies that permits the combined use of traveling wave dielectrophoresis and AC electroosmotic fluid flow.


Electronics ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 133
Author(s):  
Aleksandr Vasjanov ◽  
Vaidotas Barzdenas

Broadband amplifiers are essential building blocks used in high data rate wireless, radar, and instrumentation systems, as well as in optical communication systems. Only a traveling-wave amplifier (TWA) provides sufficient bandwidth for broadband applications without reducing modern linearization techniques. TWA requires gate-line and drain-line termination, which can be implemented on- and off-chip. This article compares the performance of identical 0.13 μm CMOS TWAs, differing only in gate-line termination placement. Measurement results revealed that the designed TWAs with on- and off-chip termination have a bandwidth of 10 GHz with a maximum gain of 15 dB and a power-added efficiency (PAE) of 5%–22% in the whole operating frequency range. Placing the gate-line termination off-chip results in an S21 flatness reduction, compared to the gain of a TWA with on-chip termination. Gain fluctuation over frequency is reduced by 4–8 dB when the termination resistor is placed as an external circuit.


Author(s):  
Sophie Loire ◽  
Paul Kauffmann ◽  
Paul Gimenez ◽  
Igor Mezić ◽  
Carl Meinhart

Thanks to its favorable reduction scale law, and its easy integration, electrokinetics has emerged over the last fifteen years as one of the major solution to drive flows in fully integrated lab-on-chip. At microscale, an efficient mixing is a keystep which can dramatically accelerate bio-reactions. For thirty years, Dynamical System theory has predicted that chaotic mixing must involve at least 3 dimensions (either time dependent 2D flows or 3D flows). However, in microfluidics, few works have yet presented efficient embedded micromixers. This paper presents experimental and theoretical study of 2D time dependent chaotic mixing using AC electrothermal fluid flows. Experiments and numerical simulations are performed on a top view device and a sideview device. In both devices, a sinusoidal electric signal is applied between 3 interdigitated gold electrodes. A phase signal Vpp = 11V and a ground are switched between the two side electrodes using a step function, whereas the opposite phase signal –Vpp is steadily applied to the center electrode (Figure 1). Flow velocity is measured by micro particle image velocimetry μ PIV. The velocity profile shows a dramatic asymmetry between the two vortices. Therefore, during the switch, vortices overlap, leading to stretching and folding flows required to obtain chaotic mixing (Figure 3 and 4). The experimental measurements validate our electrothermal models based on our previous work [1]. The mixing efficiency of low diffusive particles is studied at multiscale using the mix-variance coefficient (MVC) [2] to evaluate mixing at different scales (Figure 4). To do so, the domain is successively divided in boxes along the x and y direction up to nx and ny boxes, respectively. For each box configuration, average bead concentration is computed. The variance of these concentrations is then evaluated: MVCs=1nxny∑i=1ny∑j=1nxρij-0.52. The result of numerically evaluated MVC in Figure 2 show a dramatic increase of mixing efficiency with blinking vortices compared to steady flow. Theoretical, experimental and simulation results of the mixing process will be presented.


Lab on a Chip ◽  
2005 ◽  
Vol 5 (12) ◽  
pp. 1399 ◽  
Author(s):  
Fumihito Arai ◽  
Chinaik Ng ◽  
Hisataka Maruyama ◽  
Akihiko Ichikawa ◽  
Haitham El-Shimy ◽  
...  

Micromachines ◽  
2020 ◽  
Vol 11 (2) ◽  
pp. 119 ◽  
Author(s):  
Yi Zhang ◽  
Jing-Fu Bao ◽  
Xin-Yi Li ◽  
Xin Zhou ◽  
Zhao-Hui Wu ◽  
...  

As one of the core components of MEMS (i.e., micro-electro-mechanical systems), thin-film piezoelectric-on-silicon (TPoS) resonators experienced a blooming development in the past decades due to unique features such as a remarkable capability of integration for attractive applications of system-on-chip integrated timing references. However, the parasitic capacitive feedthrough poses a great challenge to electrical detection of resonance in a microscale silicon-based mechanical resonator. Herein, a fully-differential configuration of a TPoS MEMS resonator based on a novel structural design of dual interdigital electrodes is proposed to eliminate the negative effect of feedthrough. The fundamental principle of feedthrough suppression was comprehensively investigated by using FEA (i.e., finite-element analysis) modeling and electrical measurements of fabricated devices. It was shown that with the help of fully-differential configuration, the key parameter of SBR (i.e., signal-to-background ratio) was significantly enhanced by greatly suppressing the in-phase signal. The S-parameter measurement results further verified the effectiveness of this novel feedthrough suppression strategy, and the insertion loss and SBR of proposed TPoS resonators were improved to 4.27 dB and 42.47 dB, respectively.


Author(s):  
Abdelsalam A. Aboketaf ◽  
Liang Cao ◽  
Stefan F. Preble ◽  
Paul Ampadu

2016 ◽  
Vol 10 (1) ◽  
pp. 014118 ◽  
Author(s):  
Yinuo Cheng ◽  
Xiongying Ye ◽  
Zengshuai Ma ◽  
Shuai Xie ◽  
Wenhui Wang

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