Kinetic modeling of the dynamic PET brain data using blind source separation methods

2014 ◽  
Author(s):  
Ondrej Tichy ◽  
Vaclav Smidl
Keyword(s):  
Blind Source Separation ◽  
Kinetic Modeling ◽  
Source Separation ◽  
Dynamic Pet ◽  
Brain Data

scholarly journals Estimation of input function from dynamic PET brain data using Bayesian blind source separation

2015 ◽  
Vol 12 (4) ◽  
pp. 1273-1287
Author(s):  
Ondřej Tichý ◽  
Václav Smídl
Keyword(s):  
Blind Source Separation ◽  
Source Separation ◽  
Input Function ◽  
Time Activity ◽  
Probability Modeling ◽  
Arterial Blood ◽  
Positron Emission ◽  
Manual Interaction ◽  
Brain Data ◽  
Estimation Of Time

Selection of regions of interest in an image sequence is a typical prerequisite step for estimation of time-activity curves in dynamic positron emission tomography (PET). This procedure is done manually by a human operator and therefore suffers from subjective errors. Another such problem is to estimate the input function. It can be measured from arterial blood or it can be searched for a vascular structure on the images which is hard to be done, unreliable, and often impossible. In this study, we focus on blind source separation methods with no needs of manual interaction. Recently, we developed sparse blind source separation and deconvolution (S-BSS-vecDC) method for separation of original sources from dynamic medical data based on probability modeling and Variational Bayes approximation methodology. In this paper, we extend this method and we apply the methods on dynamic brain PET data and application and comparison of derived algorithms with those of similar assumptions are given. The S-BSS-vecDC algorithm is publicly available for download.

Sign in / Sign up

Export Citation Format

Share Document