Genetic analysis of the toxic effect of Tachyplesin I on the embryonic development of zebrafish

2013 ◽  
Author(s):  
Hongya Zhao ◽  
Jianguo Dai ◽  
Gang Jin
Keyword(s):  
Genetic Analysis ◽  
Embryonic Development ◽  
Toxic Effect ◽  
Tachyplesin I

Mitosis in Drosophila

1989 ◽  
Vol 92 (2) ◽  
pp. 137-146 ◽  
Author(s):  
D.M. Glover
Keyword(s):  
Genetic Analysis ◽  
Embryonic Development ◽  
Protein Interactions ◽  
Dynamic Process ◽  
Early Embryogenesis ◽  
Female Sterility ◽  
Protein Protein Interactions ◽  
Stages Of Development ◽  
Cell Cycles

Drosophila is an attractive organism in which to study both the rapid rounds of mitosis typical of embryonic development in many species, and the longer cell cycles of diploid tissues later in development. Mutations in genes essential for mitosis in Drosophila may result in lethality in late embryonic, larval or pupal stages of development. In addition, mutations in many genes required for the nuclear divisions of early embryogenesis have been found in screens for female sterility. The mitotic mutations have phenotypes indicative of lesions at a variety of mitotic stages. A combined molecular and genetic analysis of these genes has the potential to unravel the complex set of protein-protein interactions that occur in this dynamic process.

Effects of tachyplesin I on the embryonic development of zebrafish

2015 ◽  
pp. 999-1004
Author(s):  
Qiming Zhu ◽  
Jianguo Dai ◽  
Lijun Zhang ◽  
Gang Jin ◽  
Qingyan Jiang ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Tachyplesin I

Substantial Toxic Effect of Water-Pipe Smoking on the Early Stage of Embryonic Development

2017 ◽  
Vol 20 (4) ◽  
pp. 502-507 ◽  
Author(s):  
Anas A Ashour ◽  
Mahmoud Y Haik ◽  
Khaled W Sadek ◽  
Huseyin C Yalcin ◽  
Joanna Bitharas ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Toxic Effect ◽  
Early Stage ◽  
Water Pipe ◽  
Effect Of Water

scholarly journals Molecular and genetic analysis of the toxic effect of RAP1 overexpression in yeast.

Genetics ◽  
1995 ◽  
Vol 141 (4) ◽  
pp. 1253-1262 ◽  
Author(s):  
K Freeman ◽  
M Gwadz ◽  
D Shore
Keyword(s):  
Dna Binding ◽  
Genetic Analysis ◽  
Toxic Effect ◽  
Transcriptional Activation ◽  
Ribosomal Proteins ◽  
Regulatory Protein ◽  
Point Mutations ◽  
Binding Domain ◽  
Dna Binding Domain

Abstract Rap1p is a context-dependent regulatory protein in yeast that functions as a transcriptional activator of many essential genes, including those encoding ribosomal proteins and glycolytic enzymes. Rap1p also participates in transcriptional silencing at HM mating-type loci and telomeres. Overexpression of RAP1 strongly inhibits cell growth, perhaps by interfering with essential transcriptional activation functions within the cell. Here we report a molecular and genetic analysis of the toxic effect of RAP1 overexpression. We show that toxicity does not require the previously defined Rap1p activation and silencing domains, but instead is dependent upon the DNA-binding domain and an adjacent region of unknown function. Point mutations were identified in the DNA-binding domain that relieve the toxic effect of overexpression. Two of these mutations can complement a RAP1 deletion yet cause growth defects and altered DNA-binding properties in vitro. However, a small deletion of the adjacent (downstream) region that abolishes overexpression toxicity has, by itself, no apparent effect on growth or DNA binding. SKO1/ACR1, which encodes a CREB-like repressor protein in yeast, was isolated as a high copy suppressor of the toxicity caused by RAP1 overexpression. Models related to the regulation of Rap1p activity are discussed.

The toxic effect of aflatoxin B1 on early porcine embryonic development

2018 ◽  
Vol 118 ◽  
pp. 157-163 ◽  
Author(s):  
Kyung-Tae Shin ◽  
Jing Guo ◽  
Ying-Jie Niu ◽  
Xiang-Shun Cui
Keyword(s):  
Embryonic Development ◽  
Toxic Effect ◽  
Aflatoxin B1

Biochemical and genetic analysis of toxic effect of HOE 15030 in mammalian cells

1989 ◽  
Vol 15 (4) ◽  
pp. 279-288 ◽  
Author(s):  
Ryoji Ishida ◽  
Miwako Nishizawa ◽  
Fumiko Kohtani ◽  
Taijo Takahashi
Keyword(s):  
Genetic Analysis ◽  
Toxic Effect ◽  
Mammalian Cells

Toxic effect of palladium on embryonic development of zebrafish

2015 ◽  
Vol 159 ◽  
pp. 208-216 ◽  
Author(s):  
Mingliang Chen ◽  
Sangxia Chen ◽  
Mi Du ◽  
Shaoheng Tang ◽  
Mei Chen ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Toxic Effect

scholarly journals Cell lineages and genes

1985 ◽  
Vol 312 (1153) ◽  
pp. 101-128 ◽  
Keyword(s):  
Cell Division ◽  
Cell Differentiation ◽  
Genetic Analysis ◽  
Embryonic Development ◽  
Spatial Organization ◽  
Cell Lineages ◽  
Classical Notion ◽  
Division Pattern ◽  
Development And Evolution

Fixed lineages are the extreme manifestation of the interrelations between cell division pattern, spatial organization and cell differentiation occurring in embryonic development. These relationships are discussed in the light of recent new detailed descriptions of lineages, experimental perturbations and genetic analysis. Lineages could be phylogenetically old devices under the control of specific genes that are required to organize the morphological space. Such genes would be different from those involved in the specification of lineage alternatives. Specification genes operate independently from each other and are expressed in a combinatorial way in different cells and lineages. Since their activity is reversible during development the possibility exists for changing these combinatorial associations during development and evolution. The classical notion of a hierarchical cascade segregation of histotypes along lineages is discussed.

scholarly journals Genomic and Functional Analysis of the Toxic Effect of Tachyplesin I on the Embryonic Development of Zebrafish

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Hongya Zhao ◽  
Jianguo Dai ◽  
Gang Jin
Keyword(s):  
Toxic Effect ◽  
Antigen Processing ◽  
Horseshoe Crab ◽  
Statistical Data ◽  
Biological Processes ◽  
Embryonic Cells ◽  
Gene Expressions ◽  
Coexpressed Genes ◽  
Different Doses ◽  
Tachyplesin I

Tachyplesin I (TP I) is an antimicrobial peptide isolated from the hemocytes of the horseshoe crab. With the developments of DNA microarray technology, the genetic analysis of the toxic effect of TP I on embryo was originally considered in our recent study. Based on our microarray data of the embryonic samples of zebrafish treated with the different doses of TP I, we performed a series of statistical data analyses to explore the toxic effect of TP I at the genomic level. In this paper, we first employed the hexaMplot to illustrate the continuous variation of the gene expressions of the embryonic cells treated with the different doses of TP I. The probabilistic model-based Hough transform was used to classify these differentially coexpressed genes of TP I on the zebrafish embryos. As a result, three line rays supported with the corresponding 174 genes were detected in our analysis. Some biological processes of the featured genes, such as antigen processing, nuclear chromatin, and structural constituent of eye lens, were significantly filtered with the smallerPvalues.

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