Epigenetic profiling of DNA methylation changes associated with chronic alcohol consumption: A 12-year follow-up study

2013 ◽  
Author(s):  
Julia Tzu-Ya Weng ◽  
Lawrence Shih-Hsin Wu ◽  
Yi-Cheng Chen ◽  
Paul Wei-Che Hsu ◽  
Chau-Shoun Lee ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Alcohol Consumption ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption ◽  
Follow Up Study

scholarly journals Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon

2010 ◽  
Vol 104 (1) ◽  
pp. 24-30 ◽  
Author(s):  
Julia Sauer ◽  
Hyeran Jang ◽  
Ella M. Zimmerly ◽  
Kyong-chol Kim ◽  
Zhenhua Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Alcohol Consumption ◽  
Promoter Methylation ◽  
Genomic Dna ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption ◽  
Dietary Folate ◽  
Mouse Colon ◽  
Young Mice

Older age, dietary folate and chronic alcohol consumption are important risk factors for the development of colon cancer. The present study examined the effects of ageing, folate and alcohol on genomic and p16-specific DNA methylation, and p16 expression in the murine colon. Old (aged 18 months; n 70) and young (aged 4 months; n 70) male C57BL/6 mice were pair-fed either a Lieber-DeCarli liquid diet with alcohol (18 % of energy), a Lieber-DeCarli diet with alcohol (18 %) and reduced folate (0·25 mg folate/l) or an isoenergetic control diet (0·5 mg folate/l) for 5 or 10 weeks. Genomic DNA methylation, p16 promoter methylation and p16 gene expression were analysed by liquid chromatography–MS, methylation-specific PCR and real-time RT-PCR, respectively. Genomic DNA methylation was lower in the colon of old mice compared with young mice (P < 0·02) at 10 weeks. Alcohol consumption did not alter genomic DNA methylation in the old mouse colon, whereas it tended to decrease genomic DNA methylation in young mice (P = 0·08). p16 Promoter methylation and expression were higher in the old mouse colon compared with the corresponding young groups. There was a positive correlation between p16 promoter methylation and p16 expression in the old mouse colon (P < 0·02). In young mice the combination of alcohol and reduced dietary folate led to significantly decreased p16 expression compared with the control group (P < 0·02). In conclusion, ageing and chronic alcohol consumption alter genomic DNA methylation, p16 promoter methylation and p16 gene expression in the mouse colon, and dietary folate availability can further modify the relationship with alcohol in the young mouse.

Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption

2015 ◽  
Vol 64 ◽  
pp. 299-306 ◽  
Author(s):  
Julia Tzu-Ya Weng ◽  
Lawrence Shih-Hsin Wu ◽  
Chau-Shoun Lee ◽  
Paul Wei-Che Hsu ◽  
Andrew T.A. Cheng
Keyword(s):  
Dna Methylation ◽  
Alcohol Consumption ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption ◽  
Profiling Analysis

Changes in DNA methylation persist over time in males with severe alcohol use disorder—A longitudinal follow‐up study

2021 ◽  
Author(s):  
Soundarya Soundararajan ◽  
Arpana Agrawal ◽  
Meera Purushottam ◽  
Shravanthi Daphne Anand ◽  
Bhagyalakshmi Shankarappa ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Follow Up Study ◽  
Over Time

scholarly journals Association between the incidence of hypertension and alcohol consumption pattern and the alcohol flushing response: A 12-year follow-up study

Alcohol ◽  
2020 ◽  
Vol 89 ◽  
pp. 43-48
Author(s):  
Min-Gyu Yoo ◽  
Yoo Jeong Lee ◽  
Han Byul Jang ◽  
Hyo-Jin Kim ◽  
Hye-Ja Lee ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Consumption Pattern ◽  
Follow Up Study ◽  
Alcohol Flushing

scholarly journals Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2

2015 ◽  
Vol 12 (12) ◽  
pp. 995-999 ◽  
Author(s):  
Jan A. Graw ◽  
Clarissa von Haefen ◽  
Deniz Poyraz ◽  
Nadine Möbius ◽  
Marco Sifringer ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Uncoupling Protein ◽  
Uncoupling Protein 2 ◽  
Chronic Alcohol ◽  
Specific Expression ◽  
Chronic Alcohol Consumption ◽  
Tissue Specific ◽  
Tissue Specific Expression

Decreased Hepatotoxicity of Dimethylnitrosamine (DMN) Following Chronic Alcohol Consumption

1980 ◽  
pp. 237-243
Author(s):  
J. Gellert ◽  
F. Moreno ◽  
M. Haydn ◽  
H. Oldiges ◽  
H. Frenzel ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption

scholarly journals Chronic Alcohol Consumption Blunts β-Adrenergic Responsiveness in Left Ventricular Cardiomyocytes

2010 ◽  
Vol 98 (3) ◽  
pp. 518a
Author(s):  
Krista N. Blackwell ◽  
Dennis J. Rozanski ◽  
Dominique C. Renard-Rooney ◽  
Andrew P. Thomas
Keyword(s):  
Alcohol Consumption ◽  
Left Ventricular ◽  
Chronic Alcohol ◽  
Chronic Alcohol Consumption ◽  
Ventricular Cardiomyocytes
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