Autonomous point-based registration of prostate gland tissue images

2011 ◽  
Author(s):  
Alexandre J. Pierrot ◽  
Eduardo E. Pujol ◽  
Yachna Sharma ◽  
May D. Wangu
Keyword(s):  
Prostate Gland ◽  
Gland Tissue

scholarly journals Deflection Analysis of Different Needle Designs for Prostate Biopsy and Focal Therapy

2016 ◽  
Vol 16 (5) ◽  
pp. 654-661 ◽  
Author(s):  
Nelson N. Stone ◽  
Vladimir Mouraviev ◽  
David Schechter ◽  
Josh Goetz ◽  
M. Scott Lucia ◽  
...  
Keyword(s):  
Prostate Gland ◽  
Focal Therapy ◽  
Therapy Planning ◽  
Gelatin Matrix ◽  
Point Of Entry ◽  
Transrectal Biopsy ◽  
Significant Difference ◽  
Gland Tissue ◽  
Deflection Analysis ◽  
Needle Diameter

Objective: The biopsy needles currently used were designed for a transrectal biopsy and are known to experience significant deflection from the point of entry into the gland to the needle tip. Methods: Five designs were selected for testing: 18-gauge Bard, 15-gauge lancet tip needle with 12° vet-point cannula, and trocar tip needle with 12°, 15°, and 20° vet-point cannulas. The 15-gauge needle was designed to take a variable specimen sample between 20 and 60 mm, whereas the Bard needle specimen bed was fixed at 20 mm. The needles were bench tested on a spring-loaded platform and fired into gelatin matrix with modulus of elasticity similar to human prostate. Results: The Bard device with lancet tip needle deflected an average of 0.9 mm (range 0.3-1.3 mm) and 1.9° (range 0.6°-2.8°). Increasing needle diameter from 18-gauge Bard to 15-gauge variable with the same lancet tip needle design resulted in an average deflection across the 3 test lengths of 0.9 mm (range 0-2.0 mm) and 0.9° (range 0°-2.0°) with no significant difference. On the contrary, the use of the 3-point trocar tip needles with 12°, 15°, and 20° vet-point cannulas demonstrated significant reduction in the extent of deflection in both millimeters and degrees. There was no deflection at the 2- and 4-cm shots for both spring loads and preloads for the 3 vet tip angles tested. At 6 cm, the 20° vet tip performed the best. Conclusion: We proposed a mechanism that provides more accurate prostate sampling by combining a 3-point trocar tip on the needle with a 20° vet tip on the cutting cannula. Using the phantom, mimicking prostate gland tissue density, no deflection was revealed between 20- and 60-mm biopsy lengths, which should permit a straight sample in the majority of prostate glands and improve cancer localization for focal therapy planning.

MRI-guided fusion biopsy of the prostate resection bed among post-radical prostatectomy patients with rising PSA.

2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 208-208
Author(s):  
Cheyenne Williams ◽  
Nabila Khondakar ◽  
Michael Daneshvar ◽  
Luke P. O'Connor ◽  
Jillian Egan ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Prostate Gland ◽  
Lesion Size ◽  
Prostate Tissue ◽  
Gleason Grade ◽  
Fusion Biopsy ◽  
Grade Group ◽  
Prostate Bed ◽  
Gland Tissue ◽  
Benign Prostate

208 Background: Following treatment of prostate cancer with radical prostatectomy (RP), biochemical recurrence (BCR) can be detected with elevated PSA. This may be attributed to either cancer recurrence or retained benign prostatic gland tissue. Options for detecting malignancy after RP currently entail diagnostic imaging and biopsy with transrectal ultrasound (TRUS). TRUS alone has limited accuracy in detecting recurrence in the prostate bed. MRI fusion-guided biopsy (Fbx) may be a more accurate method of detecting post-RP local recurrence. We hypothesize that Fbx for diagnosing benign versus malignant recurrence in the prostate bed is feasible and produces clinically meaningful results. Methods: Our institutional database was queried for patients who received RP and demonstrated BCR between February 2015 and July 2020. All patients with evidence of prostate bed recurrence on mpMRI were included in this analysis. Cancer detection via mpMRI-guided fusion biopsy using the UroNav platform was evaluated and patient variables including final Gleason Grade group (GG), margin involvement, PSA at BCR, and prostate bed lesion size were analyzed with univariate logistic regression. Results: 40 patients (median age = 68) with BCR underwent post-RP mpMRI. 25/40 (62.5%) patients had MRI-visible lesions, and among those, 17/25 (68%) patients underwent Fbx of the prostate bed. 15/17 (88.2%) Fbxs detected prostate tissue (either benign or cancer), 11/17 (64.7%) contained cancer, and 4/17 (23.5%) contained benign prostate glands. Median cores per biopsy was 4 (IQR 4-6). Among the 83 cores obtained, 57 (68.6%) cores contained prostate gland tissue and 26 (31.3%) contained fibromuscular tissue. Of those 57 with gland tissue, 33 (57.9%) cores contained cancer, and 24 (42.1%) contained benign prostate tissue. Among patients with benign biopsies, none had further evidence of metastasis at median follow-up of 13.5 months after Fbx and 182 months after RP. On final RP pathology, 4 patients had GG1 disease, 4 had GG2, 4 had GG3, 2 had GG4, and 3 had GG5. 6/17 (35%) patients had positive RP margins. Median prostate bed lesion size was 1.3 cm (IQR 0.9-1.5). Prostate bed lesion size (cm) was the only variable significantly associated with cancer on Fbx (OR = 2.20, 95% CI:1.29-3.76, p = 0.011). Conclusions: mpMRI-Fbx is a feasible method for reliably targeting prostate bed lesions. With this technique, we found improved accuracy for biopsy-proven recurrence in the prostate bed. This technique will help direct treatment planning of salvage therapies among patients with detectable PSA post-RP. [Table: see text]

scholarly journals On the issue of prostatolysins. P. S. Grigoriev (Uch. Zap. Saratov Univ., vol. 1. issue 2)

1925 ◽  
Vol 21 (2) ◽  
pp. 204-204
Keyword(s):  
Prostate Gland ◽  
Organ Specificity ◽  
Gland Tissue ◽  
And Function

In order to obtain heteroprostatolysins and isoprostatolysins, to find out their organ specificity and influence on the prostate gland tissue and function P.S. Grigoriev performed a number of experiments on animals. By repeated injections under the skin of rams the emulsion from the dog prostate gland was obtained heteroprostatolytic serum. Isoprostatolytic serum was obtained from dogs prepared by injection of canine prostate gland of the same.

Development of chromatographic and electrophoretic methods for determining vinblastine in blood plasma and prostate gland tissue

2013 ◽  
Vol 68 (3) ◽  
pp. 265-271 ◽  
Author(s):  
A. A. Sidorova ◽  
D. V. Yaroshenko ◽  
E. A. Murashko ◽  
A. V. Grigor’ev
Keyword(s):  
Blood Plasma ◽  
Prostate Gland ◽  
Gland Tissue ◽  
In Blood Plasma

Diversity of Bacterial Urine and Prostate Gland Tissue Cultures in Patients Undergoing Transurethral Prostate Gland Resection

2016 ◽  
Vol 97 (3) ◽  
pp. 336-339 ◽  
Author(s):  
Stefan Heidler ◽  
Katharina Bretterbauer ◽  
Stephan Schwarz ◽  
Walter Albrecht
Keyword(s):  
Prostate Gland ◽  
Tissue Cultures ◽  
Gland Tissue

Transmission Electron Microscopy Studies of Pore Cells in Limax Maximus

1977 ◽  
Vol 35 ◽  
pp. 656-657
Author(s):  
B. S. Beltz
Keyword(s):  
Electron Microscopy ◽  
Cell Periphery ◽  
Salivary Duct ◽  
Terrestrial Mollusc ◽  
Buccal Ganglia ◽  
Transmission Electron ◽  
Pore Cells ◽  
Gland Tissue ◽  
Storage Area ◽  
Limax Maximus

The cells which are described in this study surround the salivary nerve of the terrestrial mollusc, Limax maximus. The salivary system of Limax consists of bilateral glands, ducts, and nerves. The salivary nerves originate at the buccal ganglia, which are situated on the posterior face of the buccal mass, and run along the salivary duct to the gland. The salivary nerve branches several times near the gland, and eventually sends processes into the gland.The pore cells begin to appear at the first large branch point of the salivary nerve, near the gland (Figure 1). They follow the nerve distally and eventually accompany the nerve branches into the gland tissue. The cells are 20-50 microns in diameter and contain very small nuclei (1-5 microns) (Figure 2).The cytoplasm of the pore cells is segregated into a storage area of glycogen and an organelle region located in a band around the cell periphery (Figure 3).

The Demonstration of Human Prostatic Acid Phosphatase (Pap) With Phosphorylcholine

1976 ◽  
Vol 34 ◽  
pp. 88-89
Author(s):  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Prostate Gland ◽  
Prostatic Acid Phosphatase ◽  
Human Prostate ◽  
Rat Tissues ◽  
Specific Substrate ◽  
Acid Phosphatases ◽  
Lysosomal Acid ◽  
Cacodylate Buffer

As previously reported (1, 2) phosphorylcholine (PC) is a specific substrate for prostatatic acid phosphatase (PAP) as opposed to other acid phosphatases, e.g., lysosomal acid phosphatase. The specificity of PC for PAP is due to the pentavalent nitrogen in PC, a feature that renders PC resistant to hydrolysis by all other acid phosphatases. Detailed comparative cytochemical results in rat tissues are in press. This report deals with ultracytochemical results applying the method to normal and pathological human prostate gland.Fresh human prostate was obtained from 7 patients having transurethral resections or radical prostatectomies. The tissue was fixed in 3% glutaraldehyde- 0.1 M cacodylate buffer (pH 7.4) for 15 min, sectioned at 50 μm on a Sorvall TC-2 tissue sectioner, refixed for a total of 2 hr, and rinsed overnight in 0.1 M cacodylate buffer (pH 7.4)-7.5% sucrose.

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