Surface modification of titanium with chitosan-heparin multilayers via electrostatic self-assembly technique

2010 ◽  
Author(s):  
Zhennan Deng ◽  
Dafeng Zhang ◽  
Haoyuan Huang ◽  
Jianfeng Ma
Keyword(s):  
Surface Modification ◽  
Self Assembly ◽  
Assembly Technique ◽  
Modification Of Titanium

scholarly journals Surface Modification of Titanium with Heparin-Chitosan Multilayers via Layer-by-Layer Self-Assembly Technique

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Yao Shu ◽  
Guomin Ou ◽  
Li Wang ◽  
Jingcai Zou ◽  
Quanli Li
Keyword(s):  
Surface Modification ◽  
Self Assembly ◽  
Pure Titanium ◽  
Titanium Substrate ◽  
Titanium Implants ◽  
Layer By Layer ◽  
Assembly Technique ◽  
Titanium Surfaces ◽  
Modification Of Titanium ◽  
Positively Charged

Extracellular matrix (ECM), like biomimetic surface modification of titanium implants, is a promising method for improving its biocompatibility. In this paper chitosan (Chi) and heparin (Hep) multilayer was coated on pure titanium using a layer-by-layer (LbL) self-assembly technique. The Hep-Chi multilayer growth was carried out by first depositing a single layer of positively charged poly-L-lysine (PLL) on the NaOH-treated titanium substrate (negatively charged surface), followed by alternate deposition of negatively charged Hep and positively charged Chi, and terminated by an outermost layer of Chi. The multilayer was characterized by DR-FTIR, SEM, and AFM, and osteoblasts were cocultured with the modified titanium and untreated titanium surfaces, respectively, to evaluate their cytocompatibilityin vitro. The results confirmed that Hep-Chi multilayer was fabricated gradually on the titanium surface. The Hep-Chi multilayer-coated titanium improved the adhesion, proliferation and differentiation of osteoblasts. Thus, the approach described here may provide a basis for the preparation of modified titanium surfaces for use in dental or orthopedic implants.

scholarly journals Layer-by-Layer Deposition of Hyaluronan and Quercetin-Loaded Chitosan Nanoparticles onto Titanium for Improving Blood Compatibility

Coatings ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 256 ◽  
Author(s):  
Xingda Wu ◽  
Cuijuan Liu ◽  
Hongpeng Chen ◽  
Yanfang Zhang ◽  
Lin Li ◽  
...  
Keyword(s):  
Surface Modification ◽  
Self Assembly ◽  
Platelet Adhesion ◽  
Blood Compatibility ◽  
Chitosan Nanoparticles ◽  
Uv Spectra ◽  
Multilayer Coatings ◽  
Layer By Layer ◽  
Antithrombotic Effects ◽  
Assembly Technique

Surface modification is an effective way to improve the hemocompatibility of biomaterials. Quercetin has significant anticoagulation and antithrombotic effects, and thus it is a promising candidate agent for the surface modification of blood-contacting materials. In this study, quercetin was successfully encapsulated in tripolyphosphate–chitosan nanoparticles (TCs) based on the ionic gelation of chitosan with tripolyphosphate (TPP) anions. Then, hyaluronan acid (HA)/quercetin-loaded TPP–chitosan nanoparticle (QTCs) films, in addition to HA/TCs films, were prepared separately using an electrostatic layer-by-layer self-assembly technique. The encapsulation of quercetin in the chitosan nanoparticles was confirmed by UV spectra. The quercetin-loaded multilayer coatings were also successfully self-assembled, as confirmed by the UV spectra and contact angle measurements. Platelet adhesion experiments were carried out with platelet-enriched plasma so as to evaluate the blood compatibility of the different samples. There were many platelets on the surfaces of the glass and HA/TC-coated titanium, which were partially activated but not aggregated. Meanwhile, many more platelets were observed on the uncoated titanium surfaces, most of which developed pseudopodia. By contrast, the platelet adhesion and activation were reduced remarkably on the surface of the HA/QTC-coated titanium. These results showed that the multilayer coatings containing quercetin could act as potential biomaterials to improve the anticoagulation performance of blood-contacting materials.

Multilayer composite beads constructed via layer-by-layer self-assembly for lysozyme controlled release

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24369-24376 ◽  
Author(s):  
Jiemin Zhao ◽  
Xiaoping Wang ◽  
Yanshen Kuang ◽  
Yufeng Zhang ◽  
Xiaowen Shi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Self Assembly ◽  
Cross Linking ◽  
Layer By Layer ◽  
Multilayer Composite ◽  
Composite Beads ◽  
Assembly Technique ◽  
Positively Charged

Alginate (ALG)–lysozyme (LZ) beads were fabricated by a cross-linking process. Negatively charged ALG and positively charged LZ were alternately deposited on the positively charged ALG–LZ beads via a layer-by-layer (LBL) self-assembly technique.

scholarly journals New Surface Modification of Titanium Implant with Phospho-amino Acid

2005 ◽  
Vol 24 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Yasuhiko ABE ◽  
Kyou HIASA ◽  
Maho TAKEUCHI ◽  
Yasuhiro YOSHIDA ◽  
Kazuomi SUZUKI ◽  
...  
Keyword(s):  
Surface Modification ◽  
Amino Acid ◽  
Titanium Implant ◽  
Modification Of Titanium
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