Molecular Modeling and Structure Analysis of S100 Calcium Binding Protein A14: Molecular Modeling and Structure Analysis of S100A14

2009 ◽  
Author(s):  
Taimei Zhou ◽  
Xueying Zheng ◽  
Deqing Yi ◽  
Qingying Zhang
Keyword(s):  
Molecular Modeling ◽  
Structure Analysis ◽  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
S100 Calcium Binding Protein

scholarly journals Anterior Gradient Protein 3 and S100 Calcium-Binding Protein P Levels in Different Endometrial Epithelial Compartments May Play an Important Role in Recurrent Pregnancy Failure

2021 ◽  
Vol 22 (8) ◽  
pp. 3835
Author(s):  
Nicola Tempest ◽  
Elizabeth Batchelor ◽  
Christopher J. Hill ◽  
Hannan Al-Lamee ◽  
Josephine Drury ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Binding Protein ◽  
Embryo Implantation ◽  
Calcium Signalling ◽  
Premenopausal Women ◽  
Subcellular Location ◽  
Early Embryo ◽  
Calcium Binding Protein ◽  
Regulatory Function ◽  
S100 Calcium Binding Protein

Recurrent implantation failure (RIF) and recurrent pregnancy loss (RPL) are distressing conditions without effective treatments. The luminal epithelium (LE) is integral in determining receptivity of the endometrium, whereas functionalis glands and stroma aid in nurturing early embryo development. Calcium signalling pathways are known to be of vital importance to embryo implantation and pregnancy establishment, and anterior gradient protein 3 (AGR3) and S100 calcium-binding protein P (S100P) are involved with these pathways. We initially examined 20 full-thickness endometrial biopsies from premenopausal women across the menstrual cycle to characterize levels of AGR3 protein in each endometrial sub-region at the cellular level. A further 53 endometrial pipelle biopsies collected in the window of implantation were subsequently assessed to determine differential endometrial AGR3 and S100P levels relevant to RIF (n = 13) and RPL (n = 10) in comparison with parous women (n = 30) using immunohistochemistry. Significantly higher AGR3 and S100P immunostaining was observed in ciliated cells of the LE of women with recurrent reproductive failure compared with parous women, suggesting aberrant subcellular location-associated pathophysiology for these conditions. The nuclear localisation of S100P may allow transcriptional regulatory function, which is necessary for implantation of a viable pregnancy. Further work is thus warranted to assess their utility as diagnostic/therapeutic targets.

scholarly journals Influence of Simulated Pre-Hospital Transport, Time to Analysis, and Storage Temperature on S100 Calcium-Binding Protein B Values

2020 ◽  
Vol 37 (17) ◽  
pp. 1864-1869
Author(s):  
Julie Linding Kjerulff ◽  
Sophie-Charlott Seidenfaden ◽  
Niels Juul ◽  
Mette Fogh Møller ◽  
Anna-Marie Bloch Munster ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Storage Temperature ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Transport Time ◽  
B Values ◽  
S100 Calcium Binding Protein ◽  
Hospital Transport ◽  
And Storage ◽  
Protein B
Sign in / Sign up

Export Citation Format

Share Document