Improved microarray data analysis using feature selection methods with machine learning methods

2016 ◽  
Author(s):  
Jing Sun ◽  
Kalpdrum Passi ◽  
Chakresh Kumar Jain
Keyword(s):  
Machine Learning ◽  
Feature Selection ◽  
Data Analysis ◽  
Microarray Data ◽  
Microarray Data Analysis ◽  
Selection Methods ◽  
Learning Methods ◽  
Machine Learning Methods

Gene Identification from Microarray Data for Diagnosis of Acute Myeloid and Lymphoblastic Leukemia Using a Sparse Gene Selection Method

2021 ◽  
Author(s):  
Razieh Sheikhpour ◽  
Roohallah Fazli ◽  
Sanaz Mehrabani
Keyword(s):  
Machine Learning ◽  
Feature Selection ◽  
Microarray Data ◽  
Lymphoblastic Leukemia ◽  
Feature Selection Method ◽  
Selection Method ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
Acute Myeloid ◽  
Sparse Feature Selection

Background: Microarray experiments can simultaneously determine the expression of thousands of genes. Identification of potential genes from microarray data for diagnosis of cancer is important. This study aimed to identify genes for the diagnosis of acute myeloid and lymphoblastic leukemia using a sparse feature selection method. Materials and Methods: In this descriptive study, the expression of 7129 genes of 25 patients with acute myeloid leukemia (AML), and 47 patients with lymphoblastic leukemia (ALL) achieved by the microarray technology were used in this study. Then, the important genes were identified using a sparse feature selection method to diagnose AML and ALL tissues based on the machine learning methods such as support vector machine (SVM), Gaussian kernel density estimation based classifier (GKDEC), k-nearest neighbor (KNN), and linear discriminant classifier (LDC). Results: Diagnosis of ALL and AML was done with the accuracy of 100% using 8 genes of microarray data selected by the sparse feature selection method, GKDEC, and LDC. Moreover, the KNN classifier using 6 genes and the SVM classifier using 7 genes diagnosed AML and ALL with the accuracy of 91.18% and 94.12%, respectively. The gene with the description “Paired-box protein PAX2 (PAX2) gene, exon 11 and complete CDs” was determined as the most important gene in the diagnosis of ALL and AML. Conclusion: The experimental results of the current study showed that AML and ALL can be diagnosed with high accuracy using sparse feature selection and machine learning methods. It seems that the investigation of the expression of selected genes in this study can be helpful in the diagnosis of ALL and AML.

scholarly journals Autism Spectrum Disorder Studies Using fMRI Data and Machine Learning: A Review

2021 ◽  
Vol 15 ◽  
Author(s):  
Meijie Liu ◽  
Baojuan Li ◽  
Dewen Hu
Keyword(s):  
Machine Learning ◽  
Autism Spectrum Disorder ◽  
Feature Selection ◽  
Data Exchange ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Fmri Data ◽  
Selection Methods ◽  
Learning Methods ◽  
Machine Learning Methods

Machine learning methods have been frequently applied in the field of cognitive neuroscience in the last decade. A great deal of attention has been attracted to introduce machine learning methods to study the autism spectrum disorder (ASD) in order to find out its neurophysiological underpinnings. In this paper, we presented a comprehensive review about the previous studies since 2011, which applied machine learning methods to analyze the functional magnetic resonance imaging (fMRI) data of autistic individuals and the typical controls (TCs). The all-round process was covered, including feature construction from raw fMRI data, feature selection methods, machine learning methods, factors for high classification accuracy, and critical conclusions. Applying different machine learning methods and fMRI data acquired from different sites, classification accuracies were obtained ranging from 48.3% up to 97%, and informative brain regions and networks were located. Through thorough analysis, high classification accuracies were found to usually occur in the studies which involved task-based fMRI data, single dataset for some selection principle, effective feature selection methods, or advanced machine learning methods. Advanced deep learning together with the multi-site Autism Brain Imaging Data Exchange (ABIDE) dataset became research trends especially in the recent 4 years. In the future, advanced feature selection and machine learning methods combined with multi-site dataset or easily operated task-based fMRI data may appear to have the potentiality to serve as a promising diagnostic tool for ASD.

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