Evaluating Protein Sequence Signatures Inferred from Protein-Protein Interaction Data by Gene Ontology Annotations

2008 ◽  
Author(s):  
Osamu Maruyama ◽  
Hideki Hirakawa ◽  
Takao Iwayanagi ◽  
Yoshiko Ishida ◽  
Shizu Takeda ◽  
...  
Keyword(s):  
Gene Ontology ◽  
Protein Interaction ◽  
Protein Sequence ◽  
Protein Interaction Data ◽  
Interaction Data ◽  
Protein Protein Interaction ◽  
Sequence Signatures

Discovering Interaction Motifs from Protein Interaction Networks

2009 ◽  
pp. 99-116 ◽  
Author(s):  
Hugo Willy
Keyword(s):  
Protein Interaction ◽  
Protein Interactions ◽  
Protein Interaction Networks ◽  
Interaction Networks ◽  
Protein Interaction Data ◽  
Interaction Data ◽  
Protein Patterns ◽  
Protein Protein Interaction ◽  
Family Based ◽  
High Throughput Experiments

Recent breakthroughs in high throughput experiments to determine protein-protein interaction have generated a vast amount of protein interaction data. However, most of the experiments could only answer the question of whether two proteins interact but not the question on the mechanisms by which proteins interact. Such understanding is crucial for understanding the protein interaction of an organism as a whole (the interactome) and even predicting novel protein interactions. Protein interaction usually occurs at some specific sites on the proteins and, given their importance, they are usually well conserved throughout the evolution of the proteins of the same family. Based on this observation, a number of works on finding protein patterns/motifs conserved in interacting proteins have emerged in the last few years. Such motifs are collectively termed as the interaction motifs. This chapter provides a review on the different approaches on finding interaction motifs with a discussion on their implications, potentials and possible areas of improvements in the future.

Assessment of prediction accuracy of protein function from protein-protein interaction data

Yeast ◽  
2001 ◽  
Vol 18 (6) ◽  
pp. 523-531 ◽  
Author(s):  
Haretsugu Hishigaki ◽  
Kenta Nakai ◽  
Toshihide Ono ◽  
Akira Tanigami ◽  
Toshihisa Takagi
Keyword(s):  
Protein Interaction ◽  
Protein Function ◽  
Prediction Accuracy ◽  
Protein Interaction Data ◽  
Interaction Data ◽  
Protein Protein Interaction
Sign in / Sign up

Export Citation Format

Share Document