scholarly journals Wavelet Features of the Thickness Map of Retinal Ganglion Cell-Inner Plexiform Layer Best Discriminate Prior Optic Neuritis in Patients With Multiple Sclerosis

IEEE Access ◽  
2020 ◽  
Vol 8 ◽  
pp. 221590-221598
Author(s):  
Juan Zhang ◽  
Jianhua Wang ◽  
Chen Wang ◽  
Silvia Delgado ◽  
Jeffrey Hernandez ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Retinal Ganglion ◽  
Wavelet Features

scholarly journals Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Dorothy S. K. Ng ◽  
Preeti Gupta ◽  
Yih Chung Tham ◽  
Chye Fong Peck ◽  
Tien Yin Wong ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Intraclass Correlation ◽  
Plexiform Layer ◽  
Cell Complex ◽  
Ganglion Cell Complex ◽  
Inner Plexiform Layer ◽  
Retinal Ganglion ◽  
Cell Parameters ◽  
Ganglion Cell Analysis

Purpose. To assess the repeatability of spectral-domain optical coherence tomography to measure macular and perimacular ganglion cell complex thicknesses and compare retinal ganglion cell parameters between algorithms.Methods. Ninety-two nonglaucomatous eyes from 92 participants underwent macular and perimacular ganglion cell complex thickness measurement using OCT-HS100 Glaucoma 3D algorithm and these measurements were repeated for 34 subjects. All subjects also had macular ganglion cell-inner plexiform layer thickness measured by Cirrus HD-OCT Ganglion Cell Analysis algorithm. Intraclass correlation coefficient and Pearson’s correlation analyses were performed.Results. Subfields of both macular and perimacular ganglion cell complex thicknesses had high intraclass correlation coefficient values between 0.979 (95% confidence interval [CI]: 0.958–0.989) and 0.981 (95% CI: 0.963, 0.991) and between 0.70 (95% CI: 0.481–0.838) and 0.987 (95% CI: 0.956–0.989), respectively. The overall average ganglion cell complex and macular average ganglion cell-inner plexiform layer thicknesses were strongly correlated(r=0.83, P<0.001).  Conclusions. The assessment of macular and perimacular retinal ganglion cell parameters by OCT-HS100 Glaucoma 3D algorithm is highly repeatable, and strongly correlates to retinal ganglion cell parameters assessed by Ganglion Cell Analysis algorithm. A comprehensive evaluation of retinal ganglion cells may be possible with OCT-HS100.

Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis

2006 ◽  
Vol 12 (5) ◽  
pp. 526-532 ◽  
Author(s):  
Kenneth S Shindler ◽  
Yangtai Guan ◽  
Elvira Ventura ◽  
Jean Bennett ◽  
Abdolmohamad Rostami
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Neuronal Loss ◽  
Proteolipid Protein ◽  
Cell Loss ◽  
Retinal Ganglion ◽  
Acute Optic Neuritis ◽  
Demyelinating Lesions

Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are marked by inflammatory demyelinating lesions throughout the central nervous system, including optic nerve. Neuronal loss also occurs in MS and EAE lesions, but it is not known whether neuronal loss occurs secondary to inflammation, or as a primary process. In the current study, the relationship of inflammation to retinal ganglion cell (RGC) loss during acute optic neuritis is examined. RGCs were labelled with Flourogold, and EAE was induced in SJL/J mice by immunization with proteolipid protein peptide 139- 151 (PLP). At various time points, RGCs were counted and optic nerves were examined for inflammatory cell infiltrates. No optic neuritis was detected prior to day 9 following immunization. Incidence of optic neuritis was 30% at day 9 and increased to over 70% by day 11, remaining high through day 18. In contrast, no RGC loss was detected in eyes with optic neuritis until day 14. A 43.1% reduction in RGC numbers at day 14 increased to 50.8% by day 18. No RGC loss occurred in eyes without optic neuritis. The fact that inflammation precedes RGC loss suggests that neuronal loss during optic neuritis occurs secondary to the inflammatory process.

scholarly journals Active MS is associated with accelerated retinal ganglion cell/inner plexiform layer thinning

Neurology ◽  
2012 ◽  
Vol 80 (1) ◽  
pp. 47-54 ◽  
Author(s):  
J. N. Ratchford ◽  
S. Saidha ◽  
E. S. Sotirchos ◽  
J. A. Oh ◽  
M. A. Seigo ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Retinal Ganglion
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