scholarly journals A Novel Deep Flexible Neural Forest Model for Classification of Cancer Subtypes Based on Gene Expression Data

IEEE Access ◽  
2019 ◽  
Vol 7 ◽  
pp. 22086-22095 ◽  
Author(s):  
Jing Xu ◽  
Peng Wu ◽  
Yuehui Chen ◽  
Qingfang Meng ◽  
Hussain Dawood ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Data ◽  
Expression Data ◽  
Cancer Subtypes ◽  
Forest Model

scholarly journals A Cascade Flexible Neural Forest Model for Cancer Subtypes Classification on Gene Expression Data

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Lianxin Zhong ◽  
Qingfang Meng ◽  
Yuehui Chen
Keyword(s):  
Gene Expression ◽  
Sample Size ◽  
Gene Expression Data ◽  
Small Sample Size ◽  
Small Sample ◽  
Expression Data ◽  
Cancer Subtypes ◽  
Subtype Classification ◽  
Cancer Subtype

The correct classification of cancer subtypes is of great significance for the in-depth study of cancer pathogenesis and the realization of accurate treatment for cancer patients. In recent years, the classification of cancer subtypes using deep neural networks and gene expression data has become a hot topic. However, most classifiers may face the challenges of overfitting and low classification accuracy when dealing with small sample size and high-dimensional biological data. In this paper, the Cascade Flexible Neural Forest (CFNForest) Model was proposed to accomplish cancer subtype classification. CFNForest extended the traditional flexible neural tree structure to FNT Group Forest exploiting a bagging ensemble strategy and could automatically generate the model’s structure and parameters. In order to deepen the FNT Group Forest without introducing new hyperparameters, the multilayer cascade framework was exploited to design the FNT Group Forest model, which transformed features between levels and improved the performance of the model. The proposed CFNForest model also improved the operational efficiency and the robustness of the model by sample selection mechanism between layers and setting different weights for the output of each layer. To accomplish cancer subtype classification, FNT Group Forest with different feature sets was used to enrich the structural diversity of the model, which make it more suitable for processing small sample size datasets. The experiments on RNA-seq gene expression data showed that CFNForest effectively improves the accuracy of cancer subtype classification. The classification results have good robustness.

scholarly journals A laminar augmented cascading flexible neural forest model for classification of cancer subtypes based on gene expression data

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Lianxin Zhong ◽  
Qingfang Meng ◽  
Yuehui Chen ◽  
Lei Du ◽  
Peng Wu
Keyword(s):  
Gene Expression ◽  
Gene Expression Data ◽  
Small Sample Size ◽  
Small Sample ◽  
Expression Data ◽  
Cancer Subtypes ◽  
Cancer Pathogenesis ◽  
Depth Study ◽  
And Function

Abstract Background Correctly classifying the subtypes of cancer is of great significance for the in-depth study of cancer pathogenesis and the realization of personalized treatment for cancer patients. In recent years, classification of cancer subtypes using deep neural networks and gene expression data has gradually become a research hotspot. However, most classifiers may face overfitting and low classification accuracy when dealing with small sample size and high-dimensional biology data. Results In this paper, a laminar augmented cascading flexible neural forest (LACFNForest) model was proposed to complete the classification of cancer subtypes. This model is a cascading flexible neural forest using deep flexible neural forest (DFNForest) as the base classifier. A hierarchical broadening ensemble method was proposed, which ensures the robustness of classification results and avoids the waste of model structure and function as much as possible. We also introduced an output judgment mechanism to each layer of the forest to reduce the computational complexity of the model. The deep neural forest was extended to the densely connected deep neural forest to improve the prediction results. The experiments on RNA-seq gene expression data showed that LACFNForest has better performance in the classification of cancer subtypes compared to the conventional methods. Conclusion The LACFNForest model effectively improves the accuracy of cancer subtype classification with good robustness. It provides a new approach for the ensemble learning of classifiers in terms of structural design.

Sign in / Sign up

Export Citation Format

Share Document