scholarly journals Predicting Outcomes of Nonsmall Cell Lung Cancer Using CT Image Features

IEEE Access ◽  
2014 ◽  
Vol 2 ◽  
pp. 1418-1426 ◽  
Author(s):  
Samuel H. Hawkins ◽  
John N. Korecki ◽  
Yoganand Balagurunathan ◽  
Yuhua Gu ◽  
Virendra Kumar ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer ◽  
Image Features ◽  
Ct Image

scholarly journals High quality machine-robust image features: Identification in nonsmall cell lung cancer computed tomography images

2013 ◽  
Vol 40 (12) ◽  
pp. 121916 ◽  
Author(s):  
Luke A. Hunter ◽  
Shane Krafft ◽  
Francesco Stingo ◽  
Haesun Choi ◽  
Mary K. Martel ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer ◽  
Image Features ◽  
High Quality ◽  
Computed Tomography Images ◽  
Robust Image

Study on Prognosis Factors of Non-Small Cell Lung Cancer Based on CT Image Features

2019 ◽  
Vol 9 (6) ◽  
pp. 1131-1137
Author(s):  
Xiaoteng Lu ◽  
Jing Gong ◽  
Shengdong Nie
Keyword(s):  
Lung Cancer ◽  
Survival Analysis ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Image Features ◽  
Small Cell ◽  
Ct Image ◽  
Small Cell Lung ◽  
Prognosis Factors ◽  
Second Moment

This study aims to investigate the prognosis factors of non-small cell lung cancer (NSCLC) based on CT image features and develop a new quantitative image feature prognosis approach using CT images. Firstly, lung tumors were segmented and images features were extracted. Secondly, the Kaplan-Meier method was used to have a univariate survival analysis. A multiple survival analysis was carried out with the method of COX regression model. Thirdly, SMOTE algorithm was took to make the feature data balanced. Finally, classifiers based on WEKA were established to test the prognosis ability of independent prognosis factors. Univariate analysis results reflected that six features had significant influence on patients' prognosis. After multivariate analysis, angular second moment, srhge and volume were significantly related to the survival situation of NSCLC patients (P < 0.05). According to the results of classifiers, these three features could make a well prognosis on the NSCLC. The best classification accuracy was 78.4%. The results of our study suggested that angular second moment, srhge and volume were high potential independent prognosis factors of NSCLC.

scholarly journals Complete metabolic response in patients with advanced nonsmall cell lung cancer with prolonged response to immune checkpoint inhibitor therapy

2021 ◽  
Vol 9 (3) ◽  
pp. e002262
Author(s):  
Justin Ferdinandus ◽  
Martin Metzenmacher ◽  
Lukas Kessler ◽  
Lale Umutlu ◽  
Clemens Aigner ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Lung Cancer ◽  
Metabolic Response ◽  
Standard Of Care ◽  
Nonsmall Cell Lung Cancer ◽  
Published Data ◽  
Complete Metabolic Response ◽  
Positron Emission ◽  
Checkpoint Inhibitor Therapy

IntroductionImmunotherapy is the new standard of care in advanced nonsmall cell lung cancer (NSCLC). Recently published data show that treatment discontinuation after 12 months of nivolumab treatment is associated with shorter survival. Therefore, the ideal duration of immunotherapy remains unclear, and finding markers of beneficial outcomes is of great importance. Here, we determine the proportion of complete metabolic responses (CMR) in patients who have not progressed after 24 months of immunotherapy.MethodsThis is a retrospective analysis of 45 patients with positron emission tomography using 2-[18F]fluoro-2-deoxy-D-glucose imaging for assessment of residual metabolic activity after at least 24 months. CMR was defined as uptake in tumor lesions below background levels, using mediastinum as a reference. ResultsOut of 45 patients, 29 patients had a CMR (64%). CMR was observed more frequently in non-first-line patients. Patients with CMR were younger (median 65.7 vs 75.5, p=0.03). Fourteen patients with CMR have discontinued therapy and have not progressed until time of analysis; however, median follow-up was only 5.6 (range 0.8–17.0) months.ConclusionAfter a minimum of 24 months of palliative immunotherapy for NSCLC, CMR occurred in almost two thirds of patients. Potentially, achievement of CMR might identify patients, for whom palliative immunotherapy may be safely discontinued.

scholarly journals Aberrantp16 promoter methylation in smokers and former smokers with nonsmall cell lung cancer

2003 ◽  
Vol 106 (6) ◽  
pp. 913-918 ◽  
Author(s):  
Sonata Jarmalaite ◽  
Annamaria Kannio ◽  
Sisko Anttila ◽  
Juozas R. Lazutka ◽  
Kirsti Husgafvel-Pursiainen
Keyword(s):  
Lung Cancer ◽  
Cell Lung Cancer ◽  
Promoter Methylation ◽  
Nonsmall Cell Lung Cancer ◽  
Former Smokers

Effects of postoperative epidural analgesia on recurrence-free and overall survival in patients with nonsmall cell lung cancer

2014 ◽  
Vol 26 (1) ◽  
pp. 3-17 ◽  
Author(s):  
Juan P. Cata ◽  
Vijaya Gottumukkala ◽  
Dilip Thakar ◽  
Dinesh Keerty ◽  
Rodolfo Gebhardt ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Overall Survival ◽  
Epidural Analgesia ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer ◽  
Postoperative Epidural Analgesia
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