A family history of Honeywell's large-scale computer systems

1997 ◽  
Vol 19 (4) ◽  
pp. 42-46
Author(s):  
J. King ◽  
W.A. Shelly
Keyword(s):  
Family History ◽  
Large Scale ◽  
Computer Systems ◽  
History Of

scholarly journals Type 2 Diabetes Risk Prediction Incorporating Family History Revealing a Substantial Fraction of Missing Heritability

2016 ◽  
Author(s):  
Jungsoo Gim ◽  
Wonji Kim ◽  
Soo Heon Kwak ◽  
Kyong Soo Park ◽  
Sungho Won
Keyword(s):  
Type 2 Diabetes ◽  
Family History ◽  
Risk Prediction ◽  
Genetic Variants ◽  
Large Scale ◽  
Threshold Model ◽  
Penalized Regression ◽  
Missing Heritability ◽  
History Of

ABSTRACTDespite many successes of genome-wide association (GWA) studies, known susceptibility variants identified by GWAS have the modest effect sizes and we met noticeable skepticism about the risk prediction model building with large-scale genetic data. However, in contrast with genetic variants, family history of diseases has been largely accepted as an important risk factor in clinical diagnosis and risk prediction though; complicated structures of family history of diseases have limited their application to clinical use. Here, we develop a new method which enables the incorporation of general family history of diseases with the liability threshold model and a new analysis strategy for risk prediction with penalized regression incorporating large-scale genetic variants and clinical risk factors. An application of our model to type 2 diabetes (T2D) patients in Korean population (1846 cases out of 3692 subjects) demonstrates that SNPs accounts for 28.6% of T2D’s variability and incorporation of family history leads to additional improvement of 5.9%. Our result illustrates that family history of diseases can have an invaluable information for disease prediction and may bridge the gap originated from missing heritability.

Family history of cancer and subsequent risk of cancer: A large‐scale population‐based prospective study in Japan

2019 ◽  
Vol 147 (2) ◽  
pp. 331-337 ◽  
Author(s):  
Akihisa Hidaka ◽  
Norie Sawada ◽  
Thomas Svensson ◽  
Atsushi Goto ◽  
Taiki Yamaji ◽  
...  
Keyword(s):  
Family History ◽  
Prospective Study ◽  
Large Scale ◽  
Population Based ◽  
Family History Of Cancer ◽  
Scale Population ◽  
History Of ◽  
Risk Of Cancer ◽  
History Of Cancer ◽  
Subsequent Risk

scholarly journals Ajaloolane ja arhiivinduse professor Aadu Must - 65 [Historian and professor of Archival Studies Aadu Must - 65]

2016 ◽  
pp. 155
Author(s):  
Tiit Rosenberg ◽  
Priit Pirsko
Keyword(s):  
Family History ◽  
Large Scale ◽  
Doctoral Degree ◽  
University Education ◽  
Archival Studies ◽  
Historical Sources ◽  
Senior Lecturer ◽  
Colonial Policy ◽  
History Of ◽  
The University

Aadu Must, an Estonian politician and the University of Tartu’s first Professor of Archival Studies, turned 65 on 25 March. When he went to study history at Tartu State University in 1973, Must initially proceeded along the paths of settlement history under the supervision of Professor Herbert Ligi. Over the years, the range of topics that he has dealt with has grown a great deal, encompassing family and local neighbourhood history, the colonial policy of the tsarist empire and Soviet repressions, the Estonian diaspora and Baltic German compatriots, and much more. After completing his basic university education, Must became Professor Ligi’s assistant at the university, a lecturer at the Department of General History, and later senior lecturer (1976–87). The history of the factory and town of Sindi, located in the vicinity of his home in Pärnu County, emerged at the centre of his attention, culminating in the completion of a monograph on this subject in 1985. At the end of the 1980’s, Must actively set about having his say in the ensuing political struggle, participating first in the Estonian Popular Front. He also worked for six months in Stockholm in 1991, setting up the Republic of Estonia’s information bureau there, which developed into Estonia’s embassy when the country’s independence was restored. Upon his return from Stockholm, he continued his usual work as a university lecturer while also continuing to participate in politics as time permitted, this time as a member of the Estonian Royalist Party. Since 1996, Must has been active primarily as a leading member of Estonia’s Centre Party, serving as a member of its council and board of directors, and as head of the party’s Tartu section. Must has also served as chairman of Tartu’s municipal council in 2002–07, 2009–11 and 2013–15. The intervening time periods have also included work in the Estonian Parliament, where he has served primarily on the cultural commission. At the same time, he has consistently continued his work at the university, where he built up and headed the Chair of Archival Science (1993–2014) and also served as head of the University of Tartu History Department in the interval 2004–06. In the 1990’s he completed a monograph of Estonian family names, which was issued on CD-ROM as an electronic publication (Corpus Nominum Gentilium Estonicorum). Aadu Must subsequently wrote out his broad knowledge and experiences of the study of family and local neighbourhood history in systematised form, publishing in the year Sources for the Family History of Estonians, a book providing instruction on historical sources. A new, updated edition of this book with a somewhat more popular and less academic approach (Handbook for the Researcher of Family History) was published in 2014. In the 1990’s, Must also began researching the repressive policies of the Soviet regime. Of his students, Aigi Rahi-Tamm defended her doctoral degree in 2004 (Post-Second World War Mass Repressions in Estonia: Sources and State of Research), Lea Leppik defended her dissertation in 2006 (Social Mobility of Employees of the University of Tartu in 1802–1918), and Indrek Paavle defended his doctoral dissertation in 2009 (Sovietisation of Local Administration in Estonia 1940–1950). Aadu Must is without a doubt the prime expert on Estonia’s archives and on archives concerning Estonians. As a historian and professor of archival studies, he has always been concerned by the condition of archives and access to historical sources. As a politician, he has time and again stressed the importance of the archive as an attribute of state. Must was one of the persons who drafted Estonia’s Archives Act. The gathering of material related to Estica in both the east and the west, however, has become his biggest project. This undertaking that has expanded from its initial form as the history of the fate of repressed Estonians to the current more general research of the diaspora of Estonians and persons from Estonia in the former Russian and Soviet empires has taken him to archives in St. Petersburg, Novgorod, Pskov, Tomsk, Omsk, Irkutsk, Krasnoyarsk, Vladivostok, Kazakhstan and elsewhere in Russia. All of this has placed an extensive base of sources at his disposal for planning and carrying out large-scale research projects. In recent years, many substantial studies have started emerging from Must’s pen on the history of Estonian settlers and settlements, Estonians who made careers in Russia, and Baltic German compatriots who shaped the Russian Empire’s colonial policy. Starting up the Kleio periodical for historians in 1988 is also part of the enumeration of A. Must’s accomplishments. Ten years later, Kleio restored itself as the successor of the Ajalooline Ajakiri (Estonian Historical Journal) that was first started up in 1922. Must was also part of the group that relaunched the Akadeemiline Ajalooselts (Academic Historical Society), which had been shut down in 1940.

Identifying genomic rearrangements in BRCA1 and BRCA2 in high-risk individuals for hereditary breast and ovarian cancer.

2011 ◽  
Vol 29 (27_suppl) ◽  
pp. 163-163 ◽  
Author(s):  
M. Jackson ◽  
D. Mattair ◽  
H. Lin ◽  
A. M. Gutierrez-Barrera ◽  
N. Elsayegh ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Family History ◽  
Large Scale ◽  
Cancer Center ◽  
Tumor Characteristics ◽  
Breast And Ovarian Cancer ◽  
Brca1 And Brca2 ◽  
Brca Mutations ◽  
Patient Request ◽  
History Of

163 Background: Germline mutations in the BRCA1 and BRCA2 genes are responsible for the majority of hereditary breast and ovarian cancer (HBOC). Comprehensive gene sequencing detects ~87% of BRCA mutations, and large genomic rearrangement testing (BART) accounts for ~3%. Criteria have been established to capture individuals who most likely have a BART mutation, however, recent data shows that some individuals have BART mutations and do not meet the criteria. We conducted a single-institution study to evaluate the sufficiency of BART criteria to determine if new criteria are warranted. Methods: During 2006-2008, 172 individuals underwent BRCA sequencing and BART at M. D. Anderson Cancer Center. A retrospective, IRB-approved chart review of a prospectively maintained database was conducted to determine BART criteria eligibility, personal/family history of breast and ovarian cancer and tumor characteristics. Univariate and multivariate analysis was performed to test the significance of each variable in relation to BRCA1/BRCA2 positivity. Results: Of 172 individuals, 12/34 (35%) had BRCA1 BART mutations, and 7/11 (64%) had BRCA2 BART mutations. Of the 19 individuals who tested positive for BART mutations, only 8 (42%) met BART criteria and 11 (58%) did not and proceeded with BART for various reasons (family history, insurance covered, and patient request). Individuals who were BRCA1 positive (sequencing or BART) were more likely to have ER/PR negative breast cancer (p<0.0001) and a personal (p=0.0215)/family history of ovarian cancer (p=0.0001) compared to non-carriers and individuals who had no family history Individuals who were BRCA1 sequencing positive were more likely to meet BART criteria than BRCA1 BART positive (p=0.0151) individuals. Conclusions: Given that no significant differences in family history/tumor characteristics between individuals who have sequencing and BART mutations were identified, and a majority of individuals who were BART positive do not meet BART criteria, it appears that these criteria may be insufficient. BART testing should be considered for all individuals who undergo BRCA sequencing; however, large scale collaboration studies should be conducted.

Language Onset and Concomitant Speech and Language Problems in Subgroups of Stutterers and Their Siblings

1982 ◽  
Vol 25 (4) ◽  
pp. 482-486 ◽  
Author(s):  
Robin A. Seider ◽  
Keith L. Gladstien ◽  
Kenneth K. Kidd
Keyword(s):  
Family History ◽  
Same Sex ◽  
Speech And Language ◽  
Negative Family History ◽  
Late Talkers ◽  
Language Problems ◽  
History Of ◽  
Language Onset

Time of language onset and frequencies of speech and language problems were examined in stutterers and their nonstuttering siblings. These families were grouped according to six characteristics of the index stutterer: sex, recovery or persistence of stuttering, and positive or negative family history of stuttering. Stutterers and their nonstuttering same-sex siblings were found to be distributed identically in early, average, and late categories of language onset. Comparisons of six subgroups of stutterers and their respective nonstuttering siblings showed no significant differences in the number of their reported articulation problems. Stutterers who were reported to be late talkers did not differ from their nonstuttering siblings in the frequency of their articulation problems, but these two groups had significantly higher frequencies of articulation problems than did stutterers who were early or average talkers and their siblings.

The role of a family history of adenocarcinomas in patients with Barrett oesophagus

2001 ◽  
Vol 120 (5) ◽  
pp. A442-A442
Author(s):  
P TSIBOURIS ◽  
M HENDRICKSE ◽  
P ISAACS
Keyword(s):  
Family History ◽  
History Of ◽  
Barrett Oesophagus
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