Modeling of high-dose-rate transient ionizing radiation effects in bipolar devices

2001 ◽  
Vol 48 (5) ◽  
pp. 1721-1730 ◽  
Author(s):  
T.A. Fjeldly ◽  
Y. Deng ◽  
M.S. Shur ◽  
H.P. Hjalmarson ◽  
A. Muyshondt ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Dose Rate ◽  
Radiation Effects ◽  
High Dose Rate ◽  
High Dose ◽  
Bipolar Devices

scholarly journals Perturbed transcriptional profiles after chronic low dose rate radiation in mice

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0256667
Author(s):  
Hildegunn Dahl ◽  
Dag M. Eide ◽  
Torstein Tengs ◽  
Nur Duale ◽  
Jorke H. Kamstra ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Dose Rate ◽  
Low Dose ◽  
High Dose Rate ◽  
High Dose ◽  
Transcriptional Responses ◽  
Transcriptional Profiles ◽  
Dose Rates ◽  
Low Dose Rate ◽  
Genome Wide

Adverse health outcomes of ionizing radiation given chronically at low dose rates are highly debated, a controversy also relevant for other stressors. Increased knowledge is needed for a more comprehensive understanding of the damaging potential of ionizing radiation from all dose rates and doses. There is a lack of relevant low dose rate data that is partly ascribed to the rarity of exposure facilities allowing chronic low dose rate exposures. Using the FIGARO facility, we assessed early (one day post-radiation) and late (recovery time of 100–200 days) hepatic genome-wide transcriptional profiles in male mice of two strains (CBA/CaOlaHsd and C57BL/6NHsd) exposed chronically to a low dose rate (2.5 mGy/h; 1200h, LDR), a mid-dose rate (10 mGy/h; 300h, MDR) and acutely to a high dose rate (100 mGy/h; 30h, HDR) of gamma irradiation, given to an equivalent total dose of 3 Gy. Dose-rate and strain-specific transcriptional responses were identified. Differently modulated transcriptional responses across all dose rate exposure groups were evident by the representation of functional biological pathways. Evidence of changed epigenetic regulation (global DNA methylation) was not detected. A period of recovery markedly reduced the number of differentially expressed genes. Using enrichment analysis to identify the functional significance of the modulated genes, perturbed signaling pathways associated with both cancer and non-cancer effects were observed, such as lipid metabolism and inflammation. These pathways were seen after chronic low dose rate and were not restricted to the acute high dose rate exposure. The transcriptional response induced by chronic low dose rate ionizing radiation suggests contribution to conditions such as cardiovascular diseases. We contribute with novel genome wide transcriptional data highlighting dose-rate-specific radiation responses and emphasize the importance of considering both dose rate, duration of exposure, and variability in susceptibility when assessing risks from ionizing radiation.

Effects of High Dose Rate Ionizing Radiation on Fused Silica and Sapphire Films

2013 ◽  
Vol 60 (6) ◽  
pp. 4116-4121 ◽  
Author(s):  
Michael L. McLain ◽  
Fred Hartman ◽  
Tom A. Zarick ◽  
Harold P. Hjalmarson ◽  
Joseph D. Gleason ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Dose Rate ◽  
High Dose Rate ◽  
Fused Silica ◽  
High Dose

scholarly journals The Susceptibility of ${\hbox {TaO}}_{\rm x}$-Based Memristors to High Dose Rate Ionizing Radiation and Total Ionizing Dose

2014 ◽  
Vol 61 (6) ◽  
pp. 2997-3004 ◽  
Author(s):  
Michael L. McLain ◽  
Harold P. Hjalmarson ◽  
Tim J. Sheridan ◽  
Patrick R. Mickel ◽  
Don Hanson ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Dose Rate ◽  
High Dose Rate ◽  
High Dose ◽  
Total Ionizing Dose
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