Efficient mode analysis with edge elements and 3-D adaptive refinement

1994 ◽  
Vol 42 (1) ◽  
pp. 99-107 ◽  
Author(s):  
N.A. Golias ◽  
A.G. Papagiannakis ◽  
T.D. Tsiboukis
Keyword(s):  
Adaptive Refinement ◽  
Mode Analysis ◽  
Edge Elements

scholarly journals A simple algorithm for adaptive refinement of tetrahedral meshes combined with edge elements

1993 ◽  
Vol 29 (2) ◽  
pp. 1898-1901 ◽  
Author(s):  
P. Olszewski ◽  
T. Nakata ◽  
N. Takahashi ◽  
K. Fujiwara
Keyword(s):  
Simple Algorithm ◽  
Adaptive Refinement ◽  
Edge Elements ◽  
Tetrahedral Meshes

Analisa Pola Kegagalan Balok Beton Menggunakan GFRP Bar Tanpa Selimut Beton

2020 ◽  
Vol 24 (1) ◽  
pp. 11-16
Author(s):  
Saddam - Husein ◽  
Rudy Djamaluddin ◽  
Rita Irmawaty ◽  
Kusnadi Kusnadi
Keyword(s):  
Reinforced Concrete ◽  
Concrete Beams ◽  
Concrete Cover ◽  
Steel Reinforcement ◽  
Fiber Reinforced Polymer ◽  
Mode Analysis ◽  
Flexural Capacity ◽  
Reinforced Polymer ◽  
Glass Fiber Reinforced ◽  
Gfrp Bar

SADDAM HUSEIN. Analisa Pola Kegagalan Balok Beton Menggunakan GFRP Bar Tanpa Selimut Beton (dibimbing oleh Rudi Djamaluddin dan Rita Irmawaty) Struktur beton bertulang yang menggunakan tulangan baja pada daerah korosif, menjadi rawan terhadap kerusakan atau penurunan kekuatannya akibat korosi.Korosi pada tulangan baja merupakan salah satu faktor penyebab menurunnya kekuatan struktur beton bertulang. Salah satu material yang dikembangkan mengatasi korosi adalah penggunaan material tulangan GFRP (Glass Fiber Reinforced Polymer). Penelitian ini bertujuan untuk menganalisa kapasitas lentur dan pola kegagalan balok beton tanpa selimut dengan menggunakan material tulangan GFRP bar.   Desain penelitian merupakan eksperimental laboratorium dengan rekapitulasi sebanyak 6 sampel yang terdiri dari 2 Balok beton menggunakan tulangan baja dengan selimut beton, 2 balok beton menggunakan tulangan GFRP bar dengan selimut beton, 2 balok beton menggunakan GFRP bar tanpa selimut beton. Metode pengujian dilakukan dengan dengan pengujian lentur statik monotonik dan Analisis data menggunakan uji kondisi retak awal dan kondisi ultimit.   Hasil penelitian ini menunjukkan bahwa kapasitas lentur pada balok dengan tulangan GFRP bar lebih besar dibandingkan dengan balok tulangan baja dan mampu meningkatkan kapasitas lentur balok dalam menahan beban sebesar 39.76 %, pola kegagalan beton yang terjadi pada balok tulangan baja mengalami kegagalan lentur tekan ditandai dengan retakan yang terjadi pada sisi tertekan dan membentuk retakan tegak dengan sumbu netral beton yang tertekan, sedangkan pada balok beton tulangan GFRP tanpa selimut mengalami kegagalan keruntuhan tekan geser dengan kondisi tulangan berdeformasi (bi-linear) dengan retak miring dan secara tiba-tiba menjalar menuju sumbu netral beton yang tertekan sehingga terjadilah keruntuhan secara tiba-tiba.     SADDAM HUSEIN.Failure mode analysis of concrete Beams Using GFRP rebar Without concrete cover (supervised by Rudi Djamaluddin and Rita Irmawaty)   Reinforced concrete that uses rebar steel in corrosive areas, are prone to damage or decreased strength due to corrosion. Corrosion in the steel reinforcement is one of the factors that decreasing strength of reinforced concrete. One of the materials developed to overcome corrosion is the use of GFRP (Glass Fiber Reinforced Polymer) reinforcement material. This study aims to analyze the flexural capacity and failure mode of concrete beams without concrete cover using material GFRP bar as reinforcement.   The research design was an experimental laboratory with a recapitulation of 6 samples consisting of 2 beams using steel reinforcement with concrete cover.2 concrete beams using reinforcement GFRP bar with concrete cover, 2 beams using GFRP bars without concrete cover. The  research method uses the monotonic static flexure and analyzing the data using the initial crack condition and ultimate conditions test.   The results of the research indicate the flexural capacity of the beams with GFRP bar reinforcement is higher than steel reinforcement beams and can increase 39.76% of the flexural capacity of the beams in holding loads , the failure mode analysis occurs in steel reinforcing beam experiences compressive failure. Failure was characterized  by cracks that occur on the depressing side and form an upright crack with the neutral axis of the compressed concrete, whereas in GFRP reinforced concrete beams without concrete cover, failure of shear compression with conditions of deformed reinforcement (bi-linear) with sloping cracks and suddenly spread towards the neutral axis of the compressed concrete so that there was a sudden collapse.

Application of the ESMACS Binding Free Energy Protocol to a Highly Varied Ligand Dataset: Lactate Dehydogenase A

2019 ◽  
Author(s):  
David Wright ◽  
Fouad Husseini ◽  
Shunzhou Wan ◽  
Christophe Meyer ◽  
Herman Van Vlijmen ◽  
...  
Keyword(s):  
Free Energy ◽  
Surface Area ◽  
Binding Free Energy ◽  
Normal Mode Analysis ◽  
Binding Mode ◽  
Accessible Surface Area ◽  
Solvent Accessible Surface Area ◽  
Mode Analysis ◽  
Energy Calculation ◽  
Accessible Surface

<div>Here, we evaluate the performance of our range of ensemble simulation based binding free energy calculation protocols, called ESMACS (enhanced sampling of molecular dynamics with approximation of continuum solvent) for use in fragment based drug design scenarios. ESMACS is designed to generate reproducible binding affinity predictions from the widely used molecular mechanics Poisson-Boltzmann surface area (MMPBSA) approach. We study ligands designed to target two binding pockets in the lactate dehydogenase A target protein, which vary in size, charge and binding mode. When comparing to experimental results, we obtain excellent statistical rankings across this highly diverse set of ligands. In addition, we investigate three approaches to account for entropic contributions not captured by standard MMPBSA calculations: (1) normal mode analysis, (2) weighted solvent accessible surface area (WSAS) and (3) variational entropy. </div>

Case Study and Fault Modeling for Wrong Redundancy Evaluation on DRAM Devices

2007 ◽  
Author(s):  
Martin Versen ◽  
Dorina Diaconescu ◽  
Jerome Touzel
Keyword(s):  
Failure Mode ◽  
Failure Modes ◽  
Fault Modeling ◽  
Mode Analysis ◽  
Root Cause ◽  
Failure Mode Analysis

Abstract The characterization of failure modes of DRAM is often straight forward if array related hard failures with specific addresses for localization are concerned. The paper presents a case study of a bitline oriented failure mode connected to a redundancy evaluation in the DRAM periphery. The failure mode analysis and fault modeling focus both on the root-cause and on the test aspects of the problem.

Exploring the Potential of Capsaicin Against Cancer Metastasis Based on TGF-β Signaling Modulation Through Module-based Network Pharmacology Approach

2020 ◽  
Vol 17 (5) ◽  
pp. 647-660 ◽  
Author(s):  
Shivananda Kandagalla ◽  
Sharath Belenahalli Shekarappa ◽  
Gollapalli Pavan ◽  
Umme Hani ◽  
Manjunatha Hanumanthappa
Keyword(s):  
Amino Acid ◽  
Amino Acid Composition ◽  
Signaling Pathway ◽  
Acid Composition ◽  
Protein Interaction ◽  
Cancer Metastasis ◽  
Enrichment Analysis ◽  
Functional Enrichment ◽  
Mode Analysis ◽  
Network Pharmacology

Background: Capsaicin is an active alkaloid /principal component of red pepper responsible for the pungency of chili pepper. Capsaicin by changing the intracellular redox homeostasis regulate a variety of signaling pathways ultimately producing a divergent cellular outcome. Several reports showed the potential of capsaicin against cancer metastasis, however unexplored molecular mechanism is still an active part of the research. Several growth factors have a critical role during cancer metastasis among them TGF- β signaling play a vital role. Methods: The present study aimed at analyzing capsaicin modulation of TGF-β signaling using network pharmacology approach. The chemical and protein interaction data of capsaicin was curated and abstracted using STITCH4.0, PubChem and ChEMBL database. Further, the compiled data set was subjected to the pathway and functional enrichment analysis using Protein Analysis THrough Evolutionary Relationship (PANTHER) and, Database for Annotation, Visualization, and Integrated Discovery (DAVID) database. Meanwhile, the pattern of amino acid composition across the capsaicin targets was analyzed using the EMBOSS Pepstat tool. Capsaicin targets involved in TGF- β were identified and their Protein-Protein Interaction (PPI) network constructed using STRING v10 and Cytoscape (v 3.2.1). From the above-constructed network, the clusters were mined using the MCODE clustering algorithm and finally binding affinity of capsaicin with its targets involved in TGF-β signaling pathway was analyzed using Autodock Vina. Results: The analysis explored capsaicin targets and, their associated functional and pathway annotations. Besides, the analysis also provides a detailed distinct pattern of amino acid composition across the capsaicin targets. The capsaicin targets described as MAPK14, JUN, SMAD3, MAPK3, MAPK1 and MYC involved in TGF-β signaling pathway through pathway enrichment analysis. The binding mode analysis of capsaicin with its targets has shown high affinity with MAPK3, MAPK1, JUN and MYC. Conclusion: The study explores the potential of capsaicin as a potent modulator of TGF-β signaling pathway during cancer metastasis and proposes new methodology and mechanism of action of capsaicin against TGF- β signaling pathway.

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