Single-unit neural recording with active microelectrode arrays

2001 ◽  
Vol 48 (8) ◽  
pp. 911-920 ◽  
Author(s):  
Qing Bai ◽  
K.D. Wise
Keyword(s):  
Single Unit ◽  
Microelectrode Arrays ◽  
Neural Recording

scholarly journals INITIAL SURGICAL EXPERIENCE WITH A DENSE CORTICAL MICROARRAY IN EPILEPTIC PATIENTS UNDERGOING CRANIOTOMY FOR SUBDURAL ELECTRODE IMPLANTATION

Neurosurgery ◽  
2009 ◽  
Vol 64 (3) ◽  
pp. 540-545 ◽  
Author(s):  
Allen Waziri ◽  
Catherine A. Schevon ◽  
Joshua Cappell ◽  
Ronald G. Emerson ◽  
Guy M. McKhann ◽  
...  
Keyword(s):  
Local Field ◽  
Single Unit ◽  
Microelectrode Array ◽  
Tissue Injury ◽  
Local Field Potentials ◽  
Microelectrode Arrays ◽  
Field Potentials ◽  
Surgical Experience ◽  
Electrode Implantation ◽  
Subdural Electrode

Abstract OBJECTIVE Detailed investigations of cortical physiology require the ability to record brain electrical activity at a submillimeter scale. Standard intracranial electrodes result in significant averaging of potentials generated by large numbers of neurons. In contrast, microelectrode arrays allow for recording of local field potentials and single-unit activity. We describe our initial surgical experience with the NeuroPort microelectrode array (Cyberkinetics Neurotechnology Systems, Inc., Salt Lake City, UT) in a series of patients undergoing subdural electrode implantation for epilepsy monitoring. METHODS Seven patients were implanted with and underwent semichronic recording from the NeuroPort array during standard subdural electrode monitoring for epilepsy. The electrode was placed according to company specifications in putative noneloquent epileptogenic cortex. After the monitoring period, microelectrode arrays were removed during explantation of subdural electrodes and resection of epileptogenic tissue. RESULTS Successful implantation of the microelectrode array was achieved in all patients, with minor operative difficulties. Robust and durable local field potentials and single-unit recordings were obtained from all implanted individuals. Implantation times ranged from 3 to 28 days; histological analysis of implanted tissue demonstrated no significant tissue injury or inflammatory response. There were no neurological complications or infections associated with electrode implantation or prolonged monitoring. Two patients developed postresection issues with wound healing at the site of scalp egress, with 1 requiring operative wound revision. CONCLUSION Our experience demonstrates that semichronic microelectroencephalographic recording can be safely and effectively achieved using the NeuroPort microarray. Although significant tissue injury, infection, or cerebrospinal fluid leak was not encountered, the large profile of the connection pedestal resulted in suboptimal wound closure and healing in several patients. We predict that this problem will be easily addressed in second-generation devices.

scholarly journals Microelectrode Arrays: Transparent, Flexible, Penetrating Microelectrode Arrays with Capabilities of Single‐Unit Electrophysiology (Adv. Biosys. 3/2019)

2019 ◽  
Vol 3 (3) ◽  
pp. 1970033
Author(s):  
Kyung Jin Seo ◽  
Pietro Artoni ◽  
Yi Qiang ◽  
Yiding Zhong ◽  
Xun Han ◽  
...  
Keyword(s):  
Single Unit ◽  
Microelectrode Arrays

Maskless production of neural-recording graphene microelectrode arrays

2019 ◽  
Vol 37 (2) ◽  
pp. 022202
Author(s):  
Vanessa Pereira Gomes ◽  
Aline Maria Pascon ◽  
Roberto Ricardo Panepucci ◽  
Jacobus Willibrordus Swart
Keyword(s):  
Microelectrode Arrays ◽  
Neural Recording

scholarly journals Ruthenium oxide based microelectrode arrays for in vitro and in vivo neural recording and stimulation

2020 ◽  
Vol 101 ◽  
pp. 565-574 ◽  
Author(s):  
Rahul Atmaramani ◽  
Bitan Chakraborty ◽  
Rashed T. Rihani ◽  
Joshua Usoro ◽  
Audrey Hammack ◽  
...  
Keyword(s):  
Microelectrode Arrays ◽  
Ruthenium Oxide ◽  
Neural Recording

PLATINUM-BASED CONE MICROELECTRODES FOR IMPLANTABLE NEURAL RECORDING APPLICATIONS

2010 ◽  
Vol 22 (03) ◽  
pp. 249-254
Author(s):  
Mohammad Hossein Zarifi ◽  
Javad Frounchi ◽  
Mohammad Ali Tinati ◽  
Jack W. Judy
Keyword(s):  
Fem Simulation ◽  
Microelectrode Arrays ◽  
Neural Recording ◽  
Field Extension ◽  
Chemical Environment ◽  
Simulation Environment ◽  
The Finite Element Method ◽  
Electrical Field ◽  
Neural Signal ◽  
Front End

There have been significant advances in fabrication of high-density microelectrode arrays using silicon micromachining technology in neural signal recording systems. The interface between microelectrodes and chemical environment is of great interest to researchers, working on extracellular stimulation. This interface is quite complex and must be modeled carefully to match experimental results. Computer simulation is a method to increase the knowledge about these arrays and to this end the finite element method (FEM) provides a strong environment for investigation of relative changes of the electrical field extension surrounding an electrode positioned in chemical environment. In this paper FEM simulation environment is used for modeling the metal–chemical interface, which provides helpful information about noise, impedance, and bandwidth for circuit designers to design the front-end electronics of these systems, more efficiently and reliable.

Chronic Neural Recording Using Silicon-Substrate Microelectrode Arrays Implanted in Cerebral Cortex

2004 ◽  
Vol 51 (6) ◽  
pp. 896-904 ◽  
Author(s):  
R.J. Vetter ◽  
J.C. Williams ◽  
J.F. Hetke ◽  
E.A. Nunamaker ◽  
D.R. Kipke
Keyword(s):  
Cerebral Cortex ◽  
Silicon Substrate ◽  
Microelectrode Arrays ◽  
Neural Recording

scholarly journals Multiple Single-Unit Long-Term Tracking on Organotypic Hippocampal Slices Using High-Density Microelectrode Arrays

2016 ◽  
Vol 10 ◽  
Author(s):  
Wei Gong ◽  
Jure Senčar ◽  
Douglas J. Bakkum ◽  
David Jäckel ◽  
Marie Engelene J. Obien ◽  
...  
Keyword(s):  
Single Unit ◽  
Hippocampal Slices ◽  
Microelectrode Arrays ◽  
High Density

Transparent, Flexible, Penetrating Microelectrode Arrays with Capabilities of Single‐Unit Electrophysiology

2019 ◽  
Vol 3 (3) ◽  
pp. 1800276 ◽  
Author(s):  
Kyung Jin Seo ◽  
Pietro Artoni ◽  
Yi Qiang ◽  
Yiding Zhong ◽  
Xun Han ◽  
...  
Keyword(s):  
Single Unit ◽  
Microelectrode Arrays

An Implantable 64-Channel Wireless Microsystem for Single-Unit Neural Recording

2009 ◽  
Vol 44 (9) ◽  
pp. 2591-2604 ◽  
Author(s):  
Amir M. Sodagar ◽  
Gayatri E. Perlin ◽  
Ying Yao ◽  
Khalil Najafi ◽  
Kensall D. Wise
Keyword(s):  
Single Unit ◽  
Neural Recording ◽  
Wireless Microsystem
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