OPTIMAL DETERMINATION OF DOSAGE IN PARKINSON'S DISEASE

Kybernetes ◽  
1985 ◽  
Vol 14 (2) ◽  
pp. 101-105 ◽  
Author(s):  
SELIM S. HACISALIHZADE
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease

A Review of Voltammetric Methods for Determination of Dopamine Agonists

2020 ◽  
Vol 16 ◽  
Author(s):  
Fatma Ağin
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Biological Samples ◽  
Dopamine Agonists ◽  
Modified Electrodes ◽  
Nerve Cells ◽  
Electroanalytical Methods ◽  
Voltammetry Methods ◽  
Voltammetric Methods

Background: Dopamine agonists are useful drugs for the management of patients with Parkinson's disease in the early stages and in later stages of the disease. Parkinson's disease is a progressive neurodegenerative disease that primarily affects dopamine-producing nerve cells in the brain. They bind to dopamine receptors in nerve cells that regulate body movement and motor function. Electroanalytical methods are used in medicinal, clinical and pharmaceutical research. The voltammetry is one of the most commonly used electroanalytical methods. The aims of this review are to gather and discuss studies of voltammetric methods used in determination of dopamine agonists. Method: This review includes the use of various voltammetric methods for determination studies of dopamine agonists from pharmaceutical dosage forms and biological samples. These studies were examined in terms of used voltammetric method or methods, working electrode, buffer, pH and validation parameters. Results: Cabergoline, pramipexole, ropinirole have more studies, while bromocriptine and apomorphine have fewer studies in the literature. Differential pulse voltammetry and square wave voltammetry methods were the most applied methods for determination of dopamine agonist drugs from pharmaceuticals and biological samples. But, stripping, cyclic and lineer sweep voltammetry methods are less applied methods. In this studies, a lot of modified electrodes were developed and used to analyse of dopamine agonists. Conclusion: The voltammetric methods supply determination of therapeutic agents and/or their metabolites in clinical samples at extremely low concentrations without the necessity for the sample pre-treatment or time consuming extraction steps. Also the modified electrodes and validated voltammetric methods provide good stability, repeatability, reproducibility and high recovery for the analysis of the analyte.

Sensitive and accurate determination of neurotransmitters from in vivo rat brain microdialysate of Parkinson's disease using in situ ultrasound-assisted derivatization dispersive liquid–liquid microextraction by UHPLC-MS/MS

RSC Advances ◽  
2016 ◽  
Vol 6 (110) ◽  
pp. 108635-108644 ◽  
Author(s):  
Xian-En Zhao ◽  
Yongrui He ◽  
Ping Yan ◽  
Na Wei ◽  
Renjun Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Brain ◽  
Accurate Determination ◽  
Ultrasound Assisted ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

In situ UA-DDLLME coupled with UHPLC-MS/MS has been developed for simultaneous determination of neurotransmitters and baicalein from Parkinson's disease rats.

scholarly journals DBS Programming: An Evolving Approach for Patients with Parkinson’s Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Aparna Wagle Shukla ◽  
Pam Zeilman ◽  
Hubert Fernandez ◽  
Jawad A. Bajwa ◽  
Raja Mehanna
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Symptoms ◽  
Current Approach ◽  
Efficient Control ◽  
Successful Clinical Outcome ◽  
Technological Improvements ◽  
Improve Access ◽  
Deep Brain

Deep brain stimulation (DBS) surgery is a well-established therapy for control of motor symptoms in Parkinson’s disease. Despite an appropriate targeting and an accurate placement of DBS lead, a thorough and efficient programming is critical for a successful clinical outcome. DBS programming is a time consuming and laborious manual process. The current approach involves use of general guidelines involving determination of the lead type, electrode configuration, impedance check, and battery check. However there are no validated and well-established programming protocols. In this review, we will discuss the current practice and the recent advances in DBS programming including the use of interleaving, fractionated current, directional steering of current, and the use of novel DBS pulses. These technological improvements are focused on achieving a more efficient control of clinical symptoms with the least possible side effects. Other promising advances include the introduction of computer guided programming which will likely impact the efficiency of programming for the clinicians and the possibility of remote Internet based programming which will improve access to DBS care for the patients.

Determination of Cd, Cr, Pb and Ni contents among Parkinson's disease individuals: a case­control study

2016 ◽  
Vol 127 (9) ◽  
pp. 770-775
Author(s):  
Vineeta Gupta ◽  
Nasreen Ghazi Ansari ◽  
Ravindra Kumar Garg ◽  
Sanjay Khattri
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease

scholarly journals A selective and sensitive UFLC-MS/MS method for the simultaneous determination of five alkaloids from Piper longum L. and its application in the pharmacokinetic study of 6-OHDA-induced Parkinson's disease rats

RSC Advances ◽  
2019 ◽  
Vol 9 (63) ◽  
pp. 37082-37091
Author(s):  
Rongrong Xu ◽  
Wenwen Zhao ◽  
Lan Yu ◽  
Qijun Chen ◽  
Xiaolu Hu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Simultaneous Determination ◽  
Pharmacokinetic Study ◽  
Piper Longum

Five alkaloids from Piper longum L. were simultaneously determined by UFLC-MS/MS and applied in the pharmacokinetic study in PD rats.

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