scholarly journals Get it Sorted: A Classic Endocytic Sorting Mechanism in Mammals is Conserved in Plants

2020 ◽  
Vol 32 (11) ◽  
pp. 3384-3385
Author(s):  
Jennifer Lockhart
Keyword(s):  
Endocytic Sorting

The Small GTPase Rab4 Controls an Early Endocytic Sorting Event

1993 ◽  
pp. 399-402 ◽  
Author(s):  
Peter van der Sluijs ◽  
Michael Hull ◽  
Ira Mellman
Keyword(s):  
Small Gtpase ◽  
Endocytic Sorting

scholarly journals PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors

2020 ◽  
Vol 133 (6) ◽  
pp. jcs242412 ◽  
Author(s):  
Marta I. Budzinska ◽  
David Villarroel-Campos ◽  
Matthew Golding ◽  
Anne Weston ◽  
Lucy Collinson ◽  
...  
Keyword(s):  
Neurotrophin Receptors ◽  
Endocytic Sorting

scholarly journals Membrane trafficking in osteoclasts and implications for osteoporosis

2019 ◽  
Vol 47 (2) ◽  
pp. 639-650 ◽  
Author(s):  
Pei Ying Ng ◽  
Amy Brigitte Patricia Ribet ◽  
Nathan John Pavlos
Keyword(s):  
Membrane Trafficking ◽  
Bone Matrix ◽  
Rab Gtpases ◽  
Sorting Nexin ◽  
Multinucleated Cells ◽  
Biological Studies ◽  
Endocytic Sorting ◽  
Molecular Machinery ◽  
Intracellular Organelles ◽  
Ruffled Border

Abstract Osteoclasts are large multinucleated cells exquisitely adapted to resorb bone matrix. Like other eukaryotes, osteoclasts possess an elaborate ensemble of intracellular organelles through which solutes, proteins and other macromolecules are trafficked to their target destinations via membrane-bound intermediaries. During bone resorption, membrane trafficking must be tightly regulated to sustain the structural and functional polarity of the osteoclasts’ membrane domains. Of these, the ruffled border (RB) is most characteristic, functioning as the osteoclasts' secretory apparatus. This highly convoluted organelle is classically considered to be formed by the targeted fusion of acidic vesicles with the bone-facing plasma membrane. Emerging findings disclose new evidence that the RB is far more complex than previously envisaged, possessing discrete subdomains that are serviced by several intersecting endocytic, secretory, transcytotic and autophagic pathways. Bone-resorbing osteoclasts therefore serve as a unique model system for studying polarized membrane trafficking. Recent advances in high-resolution microscopy together with the convergence of genetic and cell biological studies in humans and in mice have helped illuminate the major membrane trafficking pathways in osteoclasts and unmask the core molecular machinery that governs these distinct vesicle transport routes. Among these, small Rab GTPases, their binding partners and members of the endocytic sorting nexin family have emerged as critical regulators. This mini review summarizes our current understanding of membrane trafficking in osteoclasts, the key molecular participants, and discusses how these transport machinery may be exploited for the development of new therapies for metabolic disorders of bone-like osteoporosis.

scholarly journals Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells

2010 ◽  
Vol 190 (4) ◽  
pp. 675-691 ◽  
Author(s):  
Mark T. Howes ◽  
Matthew Kirkham ◽  
James Riches ◽  
Katia Cortese ◽  
Piers J. Walser ◽  
...  
Keyword(s):  
High Capacity ◽  
Leading Edge ◽  
Cellular Adhesion ◽  
Endocytic Pathway ◽  
Membrane Turnover ◽  
Major Pathway ◽  
Endocytic Sorting ◽  
And Migration ◽  
Sorting Station ◽  
Migrating Cells

Although the importance of clathrin- and caveolin-independent endocytic pathways has recently emerged, key aspects of these routes remain unknown. Using quantitative ultrastructural approaches, we show that clathrin-independent carriers (CLICs) account for approximately three times the volume internalized by the clathrin-mediated endocytic pathway, forming the major pathway involved in uptake of fluid and bulk membrane in fibroblasts. Electron tomographic analysis of the 3D morphology of the earliest carriers shows that they are multidomain organelles that form a complex sorting station as they mature. Proteomic analysis provides direct links between CLICs, cellular adhesion turnover, and migration. Consistent with this, CLIC-mediated endocytosis of key cargo proteins, CD44 and Thy-1, is polarized at the leading edge of migrating fibroblasts, while transient ablation of CLICs impairs their ability to migrate. These studies provide the first quantitative ultrastructural analysis and molecular characterization of the major endocytic pathway in fibroblasts, a pathway that provides rapid membrane turnover at the leading edge of migrating cells.

scholarly journals Post-endocytic Sorting of Calcitonin Receptor-like Receptor and Receptor Activity-modifying Protein 1

2007 ◽  
Vol 282 (16) ◽  
pp. 12260-12271 ◽  
Author(s):  
Graeme S. Cottrell ◽  
Benjamin Padilla ◽  
Stella Pikios ◽  
Dirk Roosterman ◽  
Martin Steinhoff ◽  
...  
Keyword(s):  
Receptor Activity ◽  
Calcitonin Receptor ◽  
Endocytic Sorting
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