scholarly journals The Tomato Guanylate-Binding Protein SlGBP1 Enables Fruit Tissue Differentiation by Maintaining Endopolyploid Cells in a Non-Proliferative State

2020 ◽  
Vol 32 (10) ◽  
pp. 3188-3205
Author(s):  
Constance Musseau ◽  
Joana Jorly ◽  
Stéphanie Gadin ◽  
Iben Sørensen ◽  
Catherine Deborde ◽  
...  
Keyword(s):  
Binding Protein ◽  
Tissue Differentiation ◽  
Fruit Tissue ◽  
Endopolyploid Cells ◽  
Guanylate Binding Protein

scholarly journals Healthy and preeclamptic pregnancies show differences in Guanylate-Binding Protein-1 plasma levels

2021 ◽  
Author(s):  
Joost H.N. Schuitemaker ◽  
Rik H.J. Beernink ◽  
Thomas I.F.H. Cremers ◽  
Sicco A. Scherjon ◽  
Maria G. Van Pampus ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Binding Protein ◽  
Guanylate Binding Protein

Nonidentical Induction of the Guanylate Binding Protein and the 56K Protein by Type I and Type II Interferons

1986 ◽  
Vol 6 (4) ◽  
pp. 417-427 ◽  
Author(s):  
YIH-SHYUN E. CHENG ◽  
MARY F. BECKER-MANLEY ◽  
THAI D. NGUYEN ◽  
WILLIAM F. DEGRADO ◽  
GERALD J. JONAK
Keyword(s):  
Binding Protein ◽  
Type I ◽  
Type Ii ◽  
Guanylate Binding Protein

Evolution of the guanylate binding protein (GBP) genes: Emergence of GBP7 genes in primates and further acquisition of a unique GBP3 gene in simians

2021 ◽  
Vol 132 ◽  
pp. 79-81
Author(s):  
João Vasco Côrte-Real ◽  
Hanna-Mari Baldauf ◽  
Joana Abrantes ◽  
Pedro José Esteves
Keyword(s):  
Binding Protein ◽  
Guanylate Binding Protein

Identification of Guanylate-Binding Protein 1 as a Potential Oral Cancer Marker Involved in Cell Invasion Using Omics-Based Analysis

2011 ◽  
Vol 10 (8) ◽  
pp. 3778-3788 ◽  
Author(s):  
Chia-Jung Yu ◽  
Kai-Ping Chang ◽  
Yin-Ju Chang ◽  
Chia-Wei Hsu ◽  
Ying Liang ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cell Invasion ◽  
Binding Protein ◽  
Cancer Marker ◽  
Guanylate Binding Protein

scholarly journals The Molecular Mechanism of Polymer Formation of Farnesylated Human Guanylate-binding Protein 1

2020 ◽  
Vol 432 (7) ◽  
pp. 2164-2185 ◽  
Author(s):  
Linda Sistemich ◽  
Miriam Kutsch ◽  
Benjamin Hämisch ◽  
Ping Zhang ◽  
Sergii Shydlovskyi ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Binding Protein ◽  
Polymer Formation ◽  
Guanylate Binding Protein

Guanylate-binding protein 6 is a novel biomarker for tumorigenesis and prognosis in tongue squamous cell carcinoma

2019 ◽  
Vol 24 (8) ◽  
pp. 2673-2682
Author(s):  
Pei-Feng Liu ◽  
Hung-Chih Chen ◽  
Chih-Wen Shu ◽  
Huei-Cin Sie ◽  
Cheng-Hsin Lee ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Binding Protein ◽  
Tongue Squamous Cell Carcinoma ◽  
Guanylate Binding Protein

Guanylate binding protein 1 (GBP-1) promotes cell motility and invasiveness of lung adenocarcinoma

2019 ◽  
Vol 518 (2) ◽  
pp. 266-272 ◽  
Author(s):  
Ichiko Yamakita ◽  
Takahiro Mimae ◽  
Yasuhiro Tsutani ◽  
Yoshihiro Miyata ◽  
Akihiko Ito ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Cell Motility ◽  
Binding Protein ◽  
Guanylate Binding Protein

scholarly journals Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma

2011 ◽  
Vol 208 (13) ◽  
pp. 2657-2673 ◽  
Author(s):  
Ming Li ◽  
Akitake Mukasa ◽  
Maria del-Mar Inda ◽  
Jianhua Zhang ◽  
Lynda Chin ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cell Invasion ◽  
Glioma Cell ◽  
Binding Protein ◽  
Brain Parenchyma ◽  
Normal Brain ◽  
Matrix Metalloproteinase 1 ◽  
Egfr Expression ◽  
Egfr Activation ◽  
Guanylate Binding Protein

Although GBP1 (guanylate binding protein 1) was among the first interferon-inducible proteins identified, its function is still largely unknown. Epidermal growth factor receptor (EGFR) activation by amplification or mutation is one of the most frequent genetic lesions in a variety of human tumors. These include glioblastoma multiforme (GBM), which is characterized by independent but interrelated features of extensive invasion into normal brain parenchyma, rapid growth, necrosis, and angiogenesis. In this study, we show that EGFR activation promoted GBP1 expression in GBM cell lines through a signaling pathway involving Src and p38 mitogen-activated protein kinase. Moreover, we identified YY1 (Yin Yang 1) as the downstream transcriptional regulator regulating EGFR-driven GBP1 expression. GBP1 was required for EGFR-mediated MMP1 (matrix metalloproteinase 1) expression and glioma cell invasion in vitro. Although deregulation of GBP1 expression did not affect glioma cell proliferation, overexpression of GBP1 enhanced glioma cell invasion through MMP1 induction, which required its C-terminal helical domain and was independent of its GTPase activity. Reducing GBP1 levels by RNA interference in invasive GBM cells also markedly inhibited their ability to infiltrate the brain parenchyma of mice. GBP1 expression was high and positively correlated with EGFR expression in human GBM tumors and cell lines, particularly those of the neural subtype. Together, these findings establish GBP1 as a previously unknown link between EGFR activity and MMP1 expression and nominate it as a novel potential therapeutic target for inhibiting GBM invasion.

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