scholarly journals Metabolome-Scale Genome-Wide Association Studies Reveal Chemical Diversity and Genetic Control of Maize Specialized Metabolites

2019 ◽  
Vol 31 (5) ◽  
pp. 937-955 ◽  
Author(s):  
Shaoqun Zhou ◽  
Karl A. Kremling ◽  
Nonoy Bandillo ◽  
Annett Richter ◽  
Ying K. Zhang ◽  
...  
Keyword(s):  
Genetic Control ◽  
Association Studies ◽  
Chemical Diversity ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Specialized Metabolites ◽  
Genome Wide

scholarly journals Metabolome-scale genome-wide association studies reveal chemical diversity and genetic control of maize specialized metabolites

2018 ◽  
Author(s):  
Zhou Shaoqun ◽  
Karl A. Kremling ◽  
Bandillo Nonoy ◽  
Richter Annett ◽  
Ying K. Zhang ◽  
...  
Keyword(s):  
Quantitative Trait ◽  
Citrate Synthase ◽  
Association Studies ◽  
Inbred Lines ◽  
Chemical Diversity ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Single Linkage ◽  
Genome Wide ◽  
Maize Varieties

One Sentence SummaryHPLC-MS metabolite profiling of maize seedlings, in combination with genome-wide association studies, identifies numerous quantitative trait loci that influence the accumulation of foliar metabolites.AbstractCultivated maize (Zea mays) retains much of the genetic and metabolic diversity of its wild ancestors. Non-targeted HPLC-MS metabolomics using a diverse panel of 264 maize inbred lines identified a bimodal distribution in the prevalence of foliar metabolites. Although 15% of the detected mass features were present in >90% of the inbred lines, the majority were found in <50% of the samples. Whereas leaf bases and tips were differentiated primarily by flavonoid abundance, maize varieties (stiff-stalk, non-stiff-stalk, tropical, sweet corn, and popcorn) were differentiated predominantly by benzoxazinoid metabolites. Genome-wide association studies (GWAS), performed for 3,991 mass features from the leaf tips and leaf bases, showed that 90% have multiple significantly associated loci scattered across the genome. Several quantitative trait locus hotspots in the maize genome regulate the abundance of multiple, often metabolically related mass features. The utility of maize metabolite GWAS was demonstrated by confirming known benzoxazinoid biosynthesis genes, as well as by mapping isomeric variation in the accumulation of phenylpropanoid hydroxycitric acid esters to a single linkage block in a citrate synthase-like gene. Similar to gene expression databases, this metabolomic GWAS dataset constitutes an important public resource for linking maize metabolites with biosynthetic and regulatory genes.

scholarly journals Meta-analysis of genome-wide association studies provides insights into genetic control of tomato flavor

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Jiantao Zhao ◽  
Christopher Sauvage ◽  
Jinghua Zhao ◽  
Frédérique Bitton ◽  
Guillaume Bauchet ◽  
...  
Keyword(s):  
Genetic Control ◽  
Association Studies ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Tomato Flavor
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