scholarly journals Receptor-Like Cytoplasmic Kinases Directly Link Diverse Pattern Recognition Receptors to the Activation of Mitogen-Activated Protein Kinase Cascades in Arabidopsis

2018 ◽  
Vol 30 (7) ◽  
pp. 1543-1561 ◽  
Author(s):  
Guozhi Bi ◽  
Zhaoyang Zhou ◽  
Weibing Wang ◽  
Lin Li ◽  
Shaofei Rao ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Protein Kinase ◽  
Pattern Recognition Receptors ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Diverse Pattern

scholarly journals Trained Immunity or Tolerance: Opposing Functional Programs Induced in Human Monocytes after Engagement of Various Pattern Recognition Receptors

2014 ◽  
Vol 21 (4) ◽  
pp. 534-545 ◽  
Author(s):  
Daniela C. Ifrim ◽  
Jessica Quintin ◽  
Leo A. B. Joosten ◽  
Cor Jacobs ◽  
Trees Jansen ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Protein Kinase ◽  
Cytokine Production ◽  
Mapk Signaling ◽  
Pattern Recognition Receptors ◽  
Mitogen Activated Protein Kinase ◽  
Long Term Effects ◽  
Fungal Cell ◽  
Content Type ◽  
Trained Immunity

ABSTRACTUpon priming withCandida albicansor with the fungal cell wall component β-glucan, monocytes respond with an increased cytokine production upon restimulation, a phenomenon termed “trained immunity.” In contrast, the prestimulation of monocytes with lipopolysaccharide has long been known to induce tolerance. Because the vast majority of commensal microorganisms belong to bacterial or viral phyla, we sought to systematically investigate the functional reprogramming of monocytes induced by the stimulation of pattern recognition receptors (PRRs) with various bacterial or viral ligands. Monocytes were functionally programmed for either enhanced (training) or decreased (tolerance) cytokine production, depending on the type and concentration of ligand they encountered. The functional reprogramming of monocytes was also associated with cell shape, granulocity, and cell surface marker modifications. The training effect required p38- and Jun N-terminal protein kinase (JNK)-mediated mitogen-activated protein kinase (MAPK) signaling, with specific signaling patterns directing the functional fate of the cell. The long-term effects on the function of monocytes were mediated by epigenetic events, with both histone methylation and acetylation inhibitors blocking the training effects. In conclusion, our experiments identify the ability of monocytes to acquire adaptive characteristics after prior activation with a wide variety of ligands. Trained immunity and tolerance are two distinct and opposing functional programs induced by the specific microbial ligands engaging the monocytes.

Age-Related Changes in Activation of Mitogen-Activated Protein Kinase Cascades by Oxidative Stress

1998 ◽  
Vol 3 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Kathryn Z Guyton ◽  
Myriani Gorospe ◽  
Xiantao Wang ◽  
Yolanda D Mock ◽  
Gertrude C Kokkonen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Age Related ◽  
Mitogen Activated Protein ◽  
Age Related Changes
Sign in / Sign up

Export Citation Format

Share Document