scholarly journals Aluminum-Activated Malate Transporters Can Facilitate GABA Transport

2018 ◽  
Vol 30 (5) ◽  
pp. 1147-1164 ◽  
Author(s):  
Sunita A. Ramesh ◽  
Muhammad Kamran ◽  
Wendy Sullivan ◽  
Larissa Chirkova ◽  
Mamoru Okamoto ◽  
...  
Keyword(s):  
Gaba Transport

Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy

2004 ◽  
Vol 449 (2) ◽  
pp. 132-142 ◽  
Author(s):  
Nicola J. Allen ◽  
Ragnhildur K�rad�ttir ◽  
David Attwell
Keyword(s):  
Gaba Transport ◽  
Cns Pathology

scholarly journals Effects of surface functionalization of hydrophilic NaYF4 nanocrystals doped with Eu3+ on glutamate and GABA transport in brain synaptosomes

2017 ◽  
Vol 19 (8) ◽  
Author(s):  
Bartlomiej Sojka ◽  
Daria Kociołek ◽  
Mateusz Banski ◽  
Tatiana Borisova ◽  
Natalia Pozdnyakova ◽  
...  
Keyword(s):  
Surface Functionalization ◽  
Gaba Transport ◽  
Brain Synaptosomes

scholarly journals GABA transporters regulate tonic and synaptic GABAA receptor-mediated currents in the suprachiasmatic nucleus neurons

2017 ◽  
Vol 118 (6) ◽  
pp. 3092-3106 ◽  
Author(s):  
Michael Moldavan ◽  
Olga Cravetchi ◽  
Charles N. Allen
Keyword(s):  
Circadian Clock ◽  
Suprachiasmatic Nucleus ◽  
Dependent Manner ◽  
Circadian Period ◽  
Gaba Concentration ◽  
Gaba Transporter ◽  
Concentration Dependent Manner ◽  
Gaba Transport ◽  
Gaba Transporters ◽  
Tonic Current

GABA is a principal neurotransmitter in the hypothalamic suprachiasmatic nucleus (SCN) that contributes to intercellular communication between individual circadian oscillators within the SCN network and the stability and precision of the circadian rhythms. GABA transporters (GAT) regulate the extracellular GABA concentration and modulate GABAA receptor (GABAAR)-mediated currents. GABA transport inhibitors were applied to study how GABAAR-mediated currents depend on the expression and function of GAT. Nipecotic acid inhibits GABA transport and induced an inward tonic current in concentration-dependent manner during whole cell patch-clamp recordings from SCN neurons. Application of either the selective GABA transporter 1 (GAT1) inhibitors NNC-711 or SKF-89976A, or the GABA transporter 3 (GAT3) inhibitor SNAP-5114, produced only small changes of the baseline current. Coapplication of GAT1 and GAT3 inhibitors induced a significant GABAAR-mediated tonic current that was blocked by gabazine. GAT inhibitors decreased the amplitude and decay time constant and increased the rise time of spontaneous GABAAR-mediated postsynaptic currents. However, inhibition of GAT did not alter the expression of either GAT1 or GAT3 in the hypothalamus. Thus GAT1 and GAT3 functionally complement each other to regulate the extracellular GABA concentration and GABAAR-mediated synaptic and tonic currents in the SCN. Coapplication of SKF-89976A and SNAP-5114 (50 µM each) significantly reduced the circadian period of Per1 expression in the SCN by 1.4 h. Our studies demonstrate that GAT are important regulators of GABAAR-mediated currents and the circadian clock in the SCN. NEW & NOTEWORTHY In the suprachiasmatic nucleus (SCN), the GABA transporters GAT1 and GAT3 are expressed in astrocytes. Inhibition of these GABA transporters increased a tonic GABA current and reduced the circadian period of Per1 expression in SCN neurons. GAT1 and GAT3 showed functional cooperativity: inhibition of one GAT increased the activity but not the expression of the other. Our data demonstrate that GABA transporters are important regulators of GABAA receptor-mediated currents and the circadian clock.

S100-glia regulation of GABA transport across the nerve cell membrane

1980 ◽  
Vol 45 (2-3) ◽  
pp. 303-316 ◽  
Author(s):  
Holger Hydén ◽  
Paul W. Lange ◽  
Sune Larsson
Keyword(s):  
Cell Membrane ◽  
Nerve Cell ◽  
Gaba Transport ◽  
Nerve Cell Membrane

Harmful impact on presynaptic glutamate and GABA transport by carbon dots synthesized from sulfur-containing carbohydrate precursor

2017 ◽  
Vol 24 (21) ◽  
pp. 17688-17700 ◽  
Author(s):  
Tatiana Borisova ◽  
Mariia Dekaliuk ◽  
Natalia Pozdnyakova ◽  
Artem Pastukhov ◽  
Marina Dudarenko ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Gaba Transport ◽  
Sulfur Containing

Presynaptic alteration of [3H]GABA transport in hippocampus by amygdala kindling

1987 ◽  
Vol 76 (3) ◽  
pp. 329-334 ◽  
Author(s):  
Isabelle Chaudieu ◽  
Gérard Rondouin ◽  
Michèle Chicheportiche ◽  
Robert Chicheportiche
Keyword(s):  
Gaba Transport ◽  
Amygdala Kindling

scholarly journals Glutamate modulation of GABA transport in retinal horizontal cells of the skate

2003 ◽  
Vol 546 (3) ◽  
pp. 717-731 ◽  
Author(s):  
Matthew A. Kreitzer ◽  
Kristen A. Andersen ◽  
Robert Paul Malchow
Keyword(s):  
Horizontal Cells ◽  
Gaba Transport
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