scholarly journals Parent-of-Origin Effects on Gene Expression and DNA Methylation in the Maize Endosperm

2011 ◽  
Vol 23 (12) ◽  
pp. 4221-4233 ◽  
Author(s):  
Amanda J. Waters ◽  
Irina Makarevitch ◽  
Steve R. Eichten ◽  
Ruth A. Swanson-Wagner ◽  
Cheng-Ting Yeh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Maize Endosperm ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals RNA Pol IV has antagonistic parent-of-origin effects on Arabidopsis endosperm

2021 ◽  
Author(s):  
P.R. V. Satyaki ◽  
Mary Gehring
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Regulatory System ◽  
Small Interfering Rnas ◽  
Pol Iv ◽  
Gene Regulatory System ◽  
Rna Polymerase Iv ◽  
Parent Of Origin ◽  
Origin Effects ◽  
Maternal Resources

Gene expression in endosperm, a seed tissue that mediates transfer of maternal resources to offspring, is under complex epigenetic control. We show here that plant-specific RNA Polymerase IV mediates parental control of endosperm gene expression. Pol IV is required for the production of small interfering RNAs that typically direct DNA methylation. We compared small RNAs, DNA methylation, and mRNAs in A. thaliana endosperm from reciprocal heterozygotes produced by crossing wildtype plants to Pol IV mutants. We find that maternally and paternally acting Pol IV have divergent effects on endosperm with loss of maternal and paternal Pol IV impacting sRNAs and DNA methylation at different genomic sites. Strikingly, maternally and paternally-acting Pol IV have antagonistic impacts on gene expression at some loci, divergently promoting or repressing endosperm gene expression. Antagonistic parent-of13 origin effects have only rarely been described and are consistent with a gene regulatory system evolving under parental conflict.

Polymorphism and parent-of-origin effects on gene expression of CAST, leptin and DGAT1 in cattle

Meat Science ◽  
2012 ◽  
Vol 90 (2) ◽  
pp. 507-510 ◽  
Author(s):  
Simone Cristina Méo Niciura ◽  
Adriana Mércia Guaratini Ibelli ◽  
Gisele Veneroni Gouveia ◽  
Juliana Gracielle Gonzaga Gromboni ◽  
Marina Ibelli Pereira Rocha ◽  
...  
Keyword(s):  
Gene Expression ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Parent-of-origin effects, allele-specific expression, genomic imprinting and paternal manipulation in social insects

2021 ◽  
Vol 376 (1826) ◽  
Author(s):  
Benjamin P. Oldroyd ◽  
Boris Yagound
Keyword(s):  
Gene Expression ◽  
Genomic Imprinting ◽  
Social Insects ◽  
Social Insect ◽  
Specific Gene ◽  
Specific Expression ◽  
Rna Molecules ◽  
Parent Of Origin ◽  
Origin Effects ◽  
Gene Expression Studies

Haplo-diploidy and the relatedness asymmetries it generates mean that social insects are prime candidates for the evolution of genomic imprinting. In single-mating social insect species, some genes may be selected to evolve genomic mechanisms that enhance reproduction by workers when they are inherited from a female. This situation reverses in multiple mating species, where genes inherited from fathers can be under selection to enhance the reproductive success of daughters. Reciprocal crosses between subspecies of honeybees have shown strong parent-of-origin effects on worker reproductive phenotypes, and this could be evidence of such genomic imprinting affecting genes related to worker reproduction. It is also possible that social insect fathers directly affect gene expression in their daughters, for example, by placing small interfering RNA molecules in semen. Gene expression studies have repeatedly found evidence of parent-specific gene expression in social insects, but it is unclear at this time whether this arises from genomic imprinting, paternal manipulation, an artefact of cyto-nuclear interactions, or all of these. This article is part of the theme issue ‘How does epigenetics influence the course of evolution?’

scholarly journals Parent-of-origin effects on seed development in Arabidopsis thaliana require DNA methylation

Development ◽  
2000 ◽  
Vol 127 (11) ◽  
pp. 2493-2502 ◽  
Author(s):  
S. Adams ◽  
R. Vinkenoog ◽  
M. Spielman ◽  
H.G. Dickinson ◽  
R.J. Scott
Keyword(s):  
Dna Methylation ◽  
Seed Development ◽  
High Weight ◽  
Transgenic Arabidopsis ◽  
Parental Genome ◽  
Wild Type ◽  
Low Weight ◽  
Parental Imprinting ◽  
Parent Of Origin ◽  
Origin Effects

Some genes in mammals and flowering plants are subject to parental imprinting, a process by which differential epigenetic marks are imposed on male and female gametes so that one set of alleles is silenced on chromosomes contributed by the mother while another is silenced on paternal chromosomes. Therefore, each genome contributes a different set of active alleles to the offspring, which develop abnormally if the parental genome balance is disturbed. In Arabidopsis, seeds inheriting extra maternal genomes show distinctive phenotypes such as low weight and inhibition of mitosis in the endosperm, while extra paternal genomes result in reciprocal phenotypes such as high weight and endosperm overproliferation. DNA methylation is known to be an essential component of the parental imprinting mechanism in mammals, but there is less evidence for this in plants. For the present study, seed development was examined in crosses using a transgenic Arabidopsis line with reduced DNA methylation. Crosses between hypomethylated and wild-type diploid plants produced similar seed phenotypes to crosses between plants with normal methylation but different ploidies. This is consistent with a model in which hypomethylation of one parental genome prevents silencing of alleles that would normally be active only when inherited from the other parent - thus phenocopying the effects of extra genomes. These results suggest an important role for methylation in parent-of-origin effects, and by inference parental imprinting, in plants. The phenotype of biparentally hypomethylated seeds is less extreme than the reciprocal phenotypes of uniparentally hypomethylated seeds. The observation that development is less severely affected if gametes of both sexes (rather than just one) are ‘neutralized’ with respect to parent-of-origin effects supports the hypothesis that parental imprinting is not necessary to regulate development.

scholarly journals Lineage and Parent-of-Origin Effects in DNA Methylation of Honey Bees (Apis mellifera) Revealed by Reciprocal Crosses and Whole-Genome Bisulfite Sequencing

2020 ◽  
Vol 12 (8) ◽  
pp. 1482-1492
Author(s):  
Xin Wu ◽  
David A Galbraith ◽  
Paramita Chatterjee ◽  
Hyeonsoo Jeong ◽  
Christina M Grozinger ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Honey Bees ◽  
Specific Expression ◽  
Africanized Honey Bee ◽  
Allele Specific ◽  
Parent Of Origin ◽  
Origin Effects ◽  
Genetic Background Effects ◽  
Allele Specific Methylation ◽  
Methylation Patterns

Abstract Parent-of-origin methylation arises when the methylation patterns of a particular allele are dependent on the parent it was inherited from. Previous work in honey bees has shown evidence of parent-of-origin-specific expression, yet the mechanisms regulating such pattern remain unknown in honey bees. In mammals and plants, DNA methylation is known to regulate parent-of-origin effects such as genomic imprinting. Here, we utilize genotyping of reciprocal European and Africanized honey bee crosses to study genome-wide allele-specific methylation patterns in sterile and reproductive individuals. Our data confirm the presence of allele-specific methylation in honey bees in lineage-specific contexts but also importantly, though to a lesser degree, parent-of-origin contexts. We show that the majority of allele-specific methylation occurs due to lineage rather than parent-of-origin factors, regardless of the reproductive state. Interestingly, genes affected by allele-specific DNA methylation often exhibit both lineage and parent-of-origin effects, indicating that they are particularly labile in terms of DNA methylation patterns. Additionally, we re-analyzed our previous study on parent-of-origin-specific expression in honey bees and found little association with parent-of-origin-specific methylation. These results indicate strong genetic background effects on allelic DNA methylation and suggest that although parent-of-origin effects are manifested in both DNA methylation and gene expression, they are not directly associated with each other.

scholarly journals A Search for Parent-of-Origin Effects on Honey Bee Gene Expression

2015 ◽  
Vol 5 (8) ◽  
pp. 1657-1662 ◽  
Author(s):  
Sarah D. Kocher ◽  
Jennifer M. Tsuruda ◽  
Joshua D. Gibson ◽  
Christine M. Emore ◽  
Miguel E. Arechavaleta-Velasco ◽  
...  
Keyword(s):  
Gene Expression ◽  
Honey Bee ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Dynamic parent-of-origin effects on small interfering RNA expression in the developing maize endosperm

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Mingming Xin ◽  
Ruolin Yang ◽  
Yingyin Yao ◽  
Chuang Ma ◽  
Huiru Peng ◽  
...  
Keyword(s):  
Small Interfering Rna ◽  
Rna Expression ◽  
Maize Endosperm ◽  
Parent Of Origin ◽  
Origin Effects ◽  
Interfering Rna

scholarly journals Genome-wide survey of parent-of-origin effects on DNA methylation identifies candidate imprinted loci in humans

2018 ◽  
Vol 27 (16) ◽  
pp. 2927-2939 ◽  
Author(s):  
Gabriel Cuellar Partida ◽  
Charles Laurin ◽  
Susan M Ring ◽  
Tom R Gaunt ◽  
Allan F McRae ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects ◽  
Genome Wide Survey

scholarly journals Abundant small RNAs in the reproductive tissues of the honey bee, Apis mellifera, are a plausible mechanism for epigenetic inheritance and parental manipulation of gene expression

2021 ◽  
Author(s):  
Owen T. Watson ◽  
Gabriele Buchmann ◽  
Paul Young ◽  
Kitty Lo ◽  
Emily J. Remnant ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sex Determination ◽  
Honey Bee ◽  
Small Rnas ◽  
Epigenetic Inheritance ◽  
Reproductive Tissues ◽  
Parental Manipulation ◽  
Plausible Mechanism ◽  
Parent Of Origin ◽  
Origin Effects

AbstractPolyandrous social insects such as the honey bee are prime candidates for parental manipulation of gene expression in offspring. Although there is good evidence for parent-of-origin effects in honey bees the epigenetic mechanisms that underlie these effects remain a mystery. Small RNA molecules such as miRNAs, piRNAs and siRNAs play important roles in transgenerational epigenetic inheritance and in the regulation of gene expression during development. Here we present the first characterisation of small RNAs present in honey bee reproductive tissues: ovaries, spermatheca, semen, fertilised and unfertilised eggs, and testes. We show that semen contains fewer piRNAs relative to eggs and ovaries, and that piRNAs and miRNAs which map antisense to genes involved in DNA regulation and developmental processes are differentially expressed between tissues. tRNA fragments are highly abundant in semen and have a similar profile to those seen in semen in other animals. Intriguingly we find abundant piRNAs that target the sex determination locus, suggesting that piRNAs may play a role in honey bee sex determination. We conclude that small RNAs play a fundamental role in honey bee gametogenesis and reproduction and provide a plausible mechanism for parent-of origin-effects on gene expression and reproductive physiology.

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