scholarly journals Nucleocytoplasmic Distribution Is Required for Activation of Resistance by the Potato NB-LRR Receptor Rx1 and Is Balanced by Its Functional Domains

2010 ◽  
Vol 22 (12) ◽  
pp. 4195-4215 ◽  
Author(s):  
Erik Slootweg ◽  
Jan Roosien ◽  
Laurentiu N. Spiridon ◽  
Andrei-Jose Petrescu ◽  
Wladimir Tameling ◽  
...  
Keyword(s):  
Functional Domains ◽  
Nucleocytoplasmic Distribution

Age dependent de-differentiation across functional domains

2012 ◽  
Vol 43 (01) ◽  
Author(s):  
C Roski ◽  
S Caspers ◽  
S Lux ◽  
S Eickhoff ◽  
K Zilles
Keyword(s):  
Functional Domains ◽  
Age Dependent

Author response for "Thrombomodulin functional domains support osteoblast differentiation and bone healing in diabetes in mice"

2020 ◽  
Author(s):  
Chung‐Hwan Chen ◽  
Chao‐Han Lai ◽  
Yi‐Kai Hong ◽  
Jui‐Ming Lu ◽  
Sung‐Yen Lin ◽  
...  
Keyword(s):  
Bone Healing ◽  
Osteoblast Differentiation ◽  
Author Response ◽  
Functional Domains ◽  
Diabetes In Mice

Molecular and genetic characterization of natural variants of HIV-1 Nef gene from North India and its functional implication in down-regulation of MHC-I and CD-4

2020 ◽  
Vol 18 ◽  
Author(s):  
J. Singh ◽  
L. Ronsard ◽  
M. Pandey ◽  
R. Kapoor ◽  
V.G. Ramachandran ◽  
...  
Keyword(s):  
Biological Activities ◽  
Sequence Similarity ◽  
Eukaryotic Expression ◽  
North India ◽  
Cell Surface Expression ◽  
Functional Domains ◽  
Wild Type ◽  
Down Regulation ◽  
Subtype B ◽  
Hiv 1

Background: HIV-1 Nef is an important accessory protein with multiple effector functions. Genetic studies of HIV-1 Nef gene shows extensive genetic diversity and the functional studies have been carried out mostly with Nef derived from regions dominated by subtype B (North America & Europe). Objective: This study was carried out to characterize genetic variations of the Nef gene from HIV-1 infected individuals from North-India and to find out their functional implications. Methods: The unique representative variants were sub-cloned in eukaryotic expression vector and further characterized with respect to their ability to down regulate cell surface expression of CD4 and MHC-1molecules. Results: The phylogenetic analysis of Nef variants revealed sequence similarity with either consensus subtype B or B/C recombinants. Boot scan analysis of some of our variants showed homology to B/C recombinant and some to wild type Nef B. Extensive variations were observed in most of the variants. The dN/dS ratio revealed 80% purifying selection and 20% diversifying selection implying the importance of mutations in Nef variants. Intracellular stability of Nef variants differed greatly when compared with wild type Nef B and C. There were some variants that possessed mutations in the functional domains of Nef and responsible for its differential CD4 and MHC-1 down regulation activity. Conclusion: We observed enhanced biological activities in some of the variants, perhaps arising out of amino acid substitutions in their functional domains. The CD4 and MHC-1 down-regulation activity of Nef is likely to confer immense survival advantage allowing the most rare genotype in a population to become the most abundant after a single selection event.

Non-canonical gender in African languages

2018 ◽  
Author(s):  
Francesca Di Garbo ◽  
Yvonne Agbetsoamedo
Keyword(s):  
Functional Domains ◽  
Derivational Morphology ◽  
African Languages ◽  
Nominal Morphology

This chapter investigates interactions between gender and number, and between gender and evaluative morphology in eighty-four African languages. It argues that interactions of gender with other grammatical domains (e.g. number) and/or with domains of derivational morphology (e.g. diminutive/augmentative) represent instances of non-canonical gender. This is based on two assumptions: (1) canonical morphosyntactic features should be maximally independent from each other, and (2) canonical gender should be an inherent lexical property of nouns, not manipulable for semantic or pragmatic purposes. The gender systems of the sampled languages appear to be frequently non-canonical because they are prone to interact with the morphosyntactic encoding of number distinctions and with the formation of diminutive and augmentative nouns. The chapter further outlines some suggestions as to how interactions between gender and other domains of nominal morphology may contribute to assess asymmetries between gender and other functional domains, as well as the complexity of gender systems.

scholarly journals Proteolytic formation and properties of functional domains of thrombomodulin.

1987 ◽  
Vol 262 (5) ◽  
pp. 2206-2212 ◽  
Author(s):  
S. Kurosawa ◽  
J.B. Galvin ◽  
N.L. Esmon ◽  
C.T. Esmon
Keyword(s):  
Functional Domains
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