scholarly journals The Trihelix Transcription Factor GTL1 Regulates Ploidy-Dependent Cell Growth in the Arabidopsis Trichome

2009 ◽  
Vol 21 (8) ◽  
pp. 2307-2322 ◽  
Author(s):  
Christian Breuer ◽  
Ayako Kawamura ◽  
Takanari Ichikawa ◽  
Rumi Tominaga-Wada ◽  
Takuji Wada ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Growth ◽  
Dependent Cell ◽  
Trihelix Transcription Factor

scholarly journals Zinc-dependent cell growth conferred by mutant tRNA synthetase.

1994 ◽  
Vol 269 (32) ◽  
pp. 20217-20220
Author(s):  
J.A. Landro ◽  
P. Schimmel
Keyword(s):  
Cell Growth ◽  
Trna Synthetase ◽  
Dependent Cell

scholarly journals Signal Transduction Involving the Dmp1 Transcription Factor and its Alteration in Human Cancer

2008 ◽  
Vol 2 ◽  
pp. CMO.S548 ◽  
Author(s):  
Takayuki Sugiyama ◽  
Donna P. Frazier ◽  
Pankaj Taneja ◽  
Robert D. Kendig ◽  
Rachel L. Morgan ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Human Cancer ◽  
Synergistic Effects ◽  
Tumor Formation ◽  
Binding Property ◽  
Lung Cancers ◽  
Myc Oncogene ◽  
Oncogenic Ras ◽  
Cycle Arrest ◽  
Dependent Cell

Summary Dmp1 (cyclin D-interacting myb-like protein 1; also called Dmtf1) is a transcription factor that has been isolated in a yeast two-hybrid screen through its binding property to cyclin D2. Dmp1 directly binds to and activates the Arf promoter and induces Arf-p53-dependent cell cycle arrest in primary cells. D-type cyclins usually inhibit Dmp1-mediated transcription in a Cdk-independent fashion; however, Dmp1 shows synergistic effects with D-cyclins on the Arf promoter. Ras or Myc oncogene-induced tumor formation is accelerated in both Dmp1+/- and Dmp1-/- mice with no significant differences between Dmp1+/- and Dmp1-/-. Thus, Dmp1 is haplo-insufficient for tumor suppression. Tumors from Dmp1-/- or Dmp1+/- mice often retain wild-type Arf and p53, suggesting that Dmp1 is a physiological regulator of the Arf-p53 pathway. The Dmp1 promoter is activated by oncogenic Ras-Raf signaling, while it is repressed by physiological mitogenic stimuli, overexpression of E2F proteins, and genotoxic stimuli mediated by NF-κB. The human DMP1 gene (h DMP1) is located on chromosome 7q21 and is hemizygously deleted in approximately 40% of human lung cancers, especially those that retain normal INK4a/ARF and P53 loci. Thus, h DMP1 is clearly involved in human carcinogenesis, and tumors with h DMP1 deletion may constitute a discrete disease entity.

scholarly journals LIM kinase 1 is required for insulin-dependent cell growth of osteosarcoma cell lines

2013 ◽  
Vol 9 (1) ◽  
pp. 103-108 ◽  
Author(s):  
HAI-SHAN ZHANG ◽  
JIAN-WU ZHAO ◽  
HONG WANG ◽  
HAN-YANG ZHANG ◽  
QIU-YE JI ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cell Lines ◽  
Osteosarcoma Cell ◽  
Lim Kinase ◽  
Lim Kinase 1 ◽  
Dependent Cell ◽  
Insulin Dependent

scholarly journals Transcription Factor SOX18 Is Expressed in Human Coronary Atherosclerotic Lesions and Regulates DNA Synthesis and Vascular Cell Growth

2005 ◽  
Vol 25 (11) ◽  
pp. 2398-2403 ◽  
Author(s):  
Marta García-Ramírez ◽  
José Martínez-González ◽  
Josep O. Juan-Babot ◽  
Cristina Rodríguez ◽  
Lina Badimon
Keyword(s):  
Transcription Factor ◽  
Cell Growth ◽  
Dna Synthesis ◽  
Vascular Cell ◽  
Atherosclerotic Lesions
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