scholarly journals Plant Retromer, Localized to the Prevacuolar Compartment and Microvesicles in Arabidopsis, May Interact with Vacuolar Sorting Receptors

2006 ◽  
Vol 18 (5) ◽  
pp. 1239-1252 ◽  
Author(s):  
Peter Oliviusson ◽  
Oliver Heinzerling ◽  
Stefan Hillmer ◽  
Giselbert Hinz ◽  
Yu Chung Tse ◽  
...  
Keyword(s):  
Vacuolar Sorting Receptors ◽  
Vacuolar Sorting ◽  
Prevacuolar Compartment

scholarly journals Anin vivoexpression system for the identification of cargo proteins of vacuolar sorting receptors in Arabidopsis culture cells

2013 ◽  
Vol 75 (6) ◽  
pp. 1003-1017 ◽  
Author(s):  
Jinbo Shen ◽  
Pui Kit Suen ◽  
Xiangfeng Wang ◽  
Youshun Lin ◽  
Sze Wan Lo ◽  
...  
Keyword(s):  
Culture Cells ◽  
Vacuolar Sorting Receptors ◽  
Cargo Proteins ◽  
Vacuolar Sorting

scholarly journals N-Linked Glycosylation Modulates Golgi-Independent Vacuolar Sorting Mediated by the Plant Specific Insert

Plants ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 312 ◽  
Author(s):  
Vanessa Vieira ◽  
Bruno Peixoto ◽  
Mónica Costa ◽  
Susana Pereira ◽  
José Pissarra ◽  
...  
Keyword(s):  
Sequence Similarity ◽  
Site Directed Mutagenesis ◽  
Research Gaps ◽  
Glycosylation Pattern ◽  
High Sequence Similarity ◽  
Post Translational Modifications ◽  
Vacuolar Sorting ◽  
Prevacuolar Compartment ◽  
Cardosin A ◽  
Comprehensive Study

In plant cells, the conventional route to the vacuole involves the endoplasmic reticulum, the Golgi and the prevacuolar compartment. However, over the years, unconventional sorting to the vacuole, bypassing the Golgi, has been described, which is the case of the Plant-Specific Insert (PSI) of the aspartic proteinase cardosin A. Interestingly, this Golgi-bypass ability is not a characteristic shared by all PSIs, since two related PSIs showed to have different sensitivity to ER-to-Golgi blockage. Given the high sequence similarity between the PSI domains, we sought to depict the differences in terms of post-translational modifications. In fact, one feature that draws our attention is that one is N-glycosylated and the other one is not. Using site-directed mutagenesis to obtain mutated versions of the two PSIs, with and without the glycosylation motif, we observed that altering the glycosylation pattern interferes with the trafficking of the protein as the non-glycosylated PSI-B, unlike its native glycosylated form, is able to bypass ER-to-Golgi blockage and accumulate in the vacuole. This is also true when the PSI domain is analyzed in the context of the full-length cardosin. Regardless of opening exciting research gaps, the results obtained so far need a more comprehensive study of the mechanisms behind this unconventional direct sorting to the vacuole.

Retromer recycles vacuolar sorting receptors from thetrans-Golgi network

2010 ◽  
Vol 61 (1) ◽  
pp. 107-121 ◽  
Author(s):  
Silke Niemes ◽  
Markus Langhans ◽  
Corrado Viotti ◽  
David Scheuring ◽  
Melody San Wan Yan ◽  
...  
Keyword(s):  
Vacuolar Sorting Receptors ◽  
Vacuolar Sorting ◽  
Golgi Network

scholarly journals Sortilin as a marker of atherosclerosis: biological and pathophysiological aspects

2021 ◽  
Vol 27 (4) ◽  
pp. 402-408
Author(s):  
I. V. Gubareva ◽  
Y. Y. Vukolova
Keyword(s):  
Cardiovascular Risk ◽  
Independent Predictor ◽  
Subclinical Atherosclerosis ◽  
Type I ◽  
Potential Therapeutic Target ◽  
Pathogenetic Role ◽  
Vacuolar Sorting Receptors ◽  
The Family ◽  
Early Biomarker ◽  
Vacuolar Sorting

Subclinical atherosclerosis is an independent predictor of increased cardiovascular risk, including patients with hypertension. The article provides an overview of the pathogenetic role in atherogenesis and cardiovascular risk stratification of sortilin peptide which belongs to the family of vacuolar sorting receptors of type I. Circulating sortilin impacts both lipid and non-lipid pathogenetic mechanisms of atherogenesis. It can serve as an early biomarker of cardiovascular risk and a potential therapeutic target for dyslipidemia management and atherosclerosis at subclinical level.

scholarly journals Mechanisms and Concepts Paving the Way towards a Complete Transport Cycle of Plant Vacuolar Sorting Receptors

2012 ◽  
Vol 24 (5) ◽  
pp. 1714-1732 ◽  
Author(s):  
Carine De Marcos Lousa ◽  
David C. Gershlick ◽  
Jurgen Denecke
Keyword(s):  
Vacuolar Sorting Receptors ◽  
Transport Cycle ◽  
Vacuolar Sorting ◽  
The Way

scholarly journals Golgi-Dependent Transport of Vacuolar Sorting Receptors Is Regulated by COPII, AP1, and AP4 Protein Complexes in Tobacco

2014 ◽  
Vol 26 (3) ◽  
pp. 1308-1329 ◽  
Author(s):  
David C. Gershlick ◽  
Carine de Marcos Lousa ◽  
Ombretta Foresti ◽  
Andrew J. Lee ◽  
Estela A. Pereira ◽  
...  
Keyword(s):  
Protein Complexes ◽  
Vacuolar Sorting Receptors ◽  
Vacuolar Sorting ◽  
Dependent Transport
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