scholarly journals Development of a Radioimmunoassay for the Soybean Phytoalexin Glyceollin I

1983 ◽  
Vol 73 (2) ◽  
pp. 233-237 ◽  
Author(s):  
Peter Moesta ◽  
Michael G. Hahn ◽  
Hans Grisebach
Keyword(s):  
Glyceollin I

scholarly journals Endocrine therapy-resistant breast cancer model cells are inhibited by soybean glyceollin I through Eleanor non-coding RNA

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Tatsuro Yamamoto ◽  
Chiyomi Sakamoto ◽  
Hiroaki Tachiwana ◽  
Mitsuru Kumabe ◽  
Toshiro Matsui ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endocrine Therapy ◽  
Cancer Model ◽  
Non Coding Rna ◽  
Breast Cancer Model ◽  
Glyceollin I

scholarly journals Characterization of Glyceollins as Novel Aryl Hydrocarbon Receptor Ligands and Their Role in Cell Migration

2020 ◽  
Vol 21 (4) ◽  
pp. 1368 ◽  
Author(s):  
Thu Ha Pham ◽  
Sylvain Lecomte ◽  
Remy Le Guevel ◽  
Aurélie Lardenois ◽  
Bertrand Evrard ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Migration ◽  
Aryl Hydrocarbon Receptor ◽  
Synergistic Effects ◽  
Binding Pocket ◽  
Migration And Invasion ◽  
Therapeutic Effects ◽  
Computational Docking ◽  
Aryl Hydrocarbon ◽  
Glyceollin I

Recent studies strongly support the use of the aryl hydrocarbon receptor (AhR) as a therapeutic target in breast cancer. Glyceollins, a group of soybean phytoalexins, are known to exert therapeutic effects in chronic human diseases and also in cancer. To investigate the interaction between glyceollin I (GI), glyceollin II (GII) and AhR, a computational docking analysis, luciferase assays, immunofluorescence and transcriptome analyses were performed with different cancer cell lines. The docking experiments predicted that GI and GII can enter into the AhR binding pocket, but their interactions with the amino acids of the binding site differ, in part, from those interacting with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Both GI and GII were able to weakly and partially activate AhR, with GII being more potent. The results from the transcriptome assays showed that approximately 10% of the genes regulated by TCDD were also modified by both GI and GII, which could have either antagonistic or synergistic effects upon TCDD activation. In addition, we report here, on the basis of phenotype, that GI and GII inhibit the migration of triple-negative (ER-, PgR-, HER2NEU-) MDA-MB-231 breast cancer cells, and that they inhibit the expression of genes which code for important regulators of cell migration and invasion in cancer tissues. In conclusion, GI and GII are AhR ligands that should be further investigated to determine their usefulness in cancer treatments.

Total Syntheses of Racemic, Natural (−) and Unnatural (+) Glyceollin I

2008 ◽  
Vol 10 (21) ◽  
pp. 5007-5010 ◽  
Author(s):  
Rahul S. Khupse ◽  
Paul W. Erhardt
Keyword(s):  
Total Syntheses ◽  
Glyceollin I

scholarly journals Glyceollin I in Soybean-Cyst Nematode Interactions

1991 ◽  
Vol 96 (4) ◽  
pp. 1302-1307 ◽  
Author(s):  
Jeng-Sheng Huang ◽  
Kenneth R. Barker
Keyword(s):  
Soybean Cyst Nematode ◽  
Cyst Nematode ◽  
Glyceollin I

Biomimetic Syntheses and Antiproliferative Activities of Racemic, Natural (−), and Unnnatural (+) Glyceollin I

2011 ◽  
Vol 54 (10) ◽  
pp. 3506-3523 ◽  
Author(s):  
Rahul S. Khupse ◽  
Jeffrey G. Sarver ◽  
Jill A. Trendel ◽  
Nicole R. Bearss ◽  
Michael D. Reese ◽  
...  
Keyword(s):  
Glyceollin I ◽  
Antiproliferative Activities

Formal synthesis of soybean phytoalexin glyceollin I

2014 ◽  
Vol 55 (10) ◽  
pp. 1826-1828 ◽  
Author(s):  
Yuta Kohno ◽  
Masatsugu Koso ◽  
Masaki Kuse ◽  
Hirosato Takikawa
Keyword(s):  
Formal Synthesis ◽  
Glyceollin I
Sign in / Sign up

Export Citation Format

Share Document