scholarly journals THE BIOSYNTHESIS OF CARBON-14-LABELED COMPOUNDS. I. THE CHROMATOGRAPHIC SEPARATION OF GLUCOSE AND FRUCTOSE

1951 ◽  
Vol 26 (1) ◽  
pp. 174-181 ◽  
Author(s):  
G. R. Noggle ◽  
René A. Bolomey
Keyword(s):  
Chromatographic Separation ◽  
Labeled Compounds ◽  
Carbon 14

Radioassay by Gas Chromatography of Tritium- and Carbon-14-Labeled Compounds

1958 ◽  
Vol 30 (5) ◽  
pp. 903-906 ◽  
Author(s):  
Richard. Wolfgang ◽  
F. S. Rowland
Keyword(s):  
Gas Chromatography ◽  
Labeled Compounds ◽  
Carbon 14

scholarly journals Continuous C14O2 and CO2 Excretion Studies in Experimental Animals

1956 ◽  
Vol 185 (2) ◽  
pp. 269-274 ◽  
Author(s):  
B. M. Tolbert ◽  
Martha Kirk ◽  
E. M. Baker
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Continuous Measurement ◽  
Specific Activity ◽  
Total Activity ◽  
Large Animal ◽  
Labeled Compounds ◽  
Experimental Animals ◽  
Carbon 14 ◽  
Co2 Excretion

An apparatus has been devised which permits, after administration of labeled compounds to animals, the continuous measurement and recording of CO2 excretion by means of infrared absorption, C14 excretion by ion chambers, and specific activity by a ratio analyzer. Comparative excretion studies have been made using labeled amino acids, fats, fatty acids and sugars. The specific activity and total activity rate curves for breath carbon-14 are markedly different. The generally smooth nature of the specific activity curves gives an excellent indication of the continuous and steady processes by which radioactivity is distributed into the various body pools. Studies have been made with mice, rats, guinea pigs and rabbits. As small an amount as 0.1 µc C14 has been used for an 8-hour study in mice. The instrument can be readily adapted for use in large animal or human studies following administration of small amounts of C14.

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