scholarly journals Holliday Junction Resolvase MOC1 Maintains Plastid and Mitochondrial Genome Integrity in Algae and Bryophytes

2020 ◽  
Vol 184 (4) ◽  
pp. 1870-1883
Author(s):  
Yusuke Kobayashi ◽  
Masaki Odahara ◽  
Yasuhiko Sekine ◽  
Takashi Hamaji ◽  
Sumire Fujiwara ◽  
...  
Keyword(s):  
Mitochondrial Genome ◽  
Holliday Junction ◽  
Genome Integrity ◽  
Holliday Junction Resolvase

scholarly journals The Mitochondrial Genome Integrity Gene, MGI1, of Kluyveromyces lactis Encodes the β-Subunit of F1-ATPase

Genetics ◽  
1996 ◽  
Vol 144 (4) ◽  
pp. 1445-1454 ◽  
Author(s):  
Xin Jie Chen ◽  
G Desmond Clark-Walker
Keyword(s):  
Mitochondrial Genome ◽  
Kluyveromyces Lactis ◽  
Three Dimensional ◽  
Genome Integrity ◽  
Dimensional Structure ◽  
Deletion Mutants ◽  
Β Subunit ◽  
Gain Of Function ◽  
F1 Atpase ◽  
Γ Subunit

In a previous report, we found that mutations at the mitochondrial genome integrity locus, MGI1, can convert Kluyveromyces lactis into a petite-positive yeast. In this report, we describe the isolation of the MGI1 gene and show that it encodes the β-subunit of the mitochondrial F1-ATPase. The site of mutation in four independently isolated mgi1 alleles is at Arg435, which has changed to Gly in three cases and Ile in the fourth isolate. Disruption of MGI1 does not lead to the production of mitochondrial genome deletion mutants, indicating that an assembled F1 complex is needed for the “gain-of-function” phenotype found in mgi1 point mutants. The location of Arg435 in the β-subunit, as deduced from the three-dimensional structure of the bovine F1-ATPase, together with mutational sites in the previously identified mgi2 and mgi5 alleles, suggests that interaction of the β- and α- (MGI2) subunits with the γ-subunit (MGI5) is likely to be affected by the mutations.

A Test of the Double-Strand Break Repair Model for Meiotic Recombination in Saccharomyces cerevisiae

Genetics ◽  
1996 ◽  
Vol 144 (1) ◽  
pp. 27-41 ◽  
Author(s):  
Larry A Gilbertson ◽  
Franklin W Stahl
Keyword(s):  
Meiotic Recombination ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Holliday Junction ◽  
Single Event ◽  
Heteroduplex Dna ◽  
Holliday Junction Resolvase ◽  
Break Repair ◽  
Two Sides

Abstract We tested predictions of the double-strand break repair (DSBR) model for meiotic recombination by examining the segregation patterns of small palindromic insertions, which frequently escape mismatch repair when in heteroduplex DNA. The palindromes flanked a well characterized DSB site at the ARC4 locus. The “canonical” DSBR model, in which only 5′ ends are degraded and resolution of the four-stranded intermediate is by Holliday junction resolvase, predicts that hDNA will frequently occur on both participating chromatids in a single event. Tetrads reflecting this configuration of hDNA were rare. In addition, a class of tetrads not predicted by the canonical DSBR model was identified. This class represented events that produced hDNA in a “trans” configuration, on opposite strands of the same duplex on the two sides of the DSB site. Whereas most classes of convertant tetrads had typical frequencies of associated crossovers, tetrads with trans hDNA were parental for flanking markers. Modified versions of the DSBR model, including one that uses a topoisomerase to resolve the canonical DSBR intermediate, are supported by these data.

scholarly journals Mus81-Eme1 Are Essential Components of a Holliday Junction Resolvase

Cell ◽  
2001 ◽  
Vol 107 (4) ◽  
pp. 537-548 ◽  
Author(s):  
Michael N. Boddy ◽  
Pierre-Henri L. Gaillard ◽  
W.Hayes McDonald ◽  
Paul Shanahan ◽  
John R. Yates ◽  
...  
Keyword(s):  
Holliday Junction ◽  
Essential Components ◽  
Holliday Junction Resolvase

scholarly journals CKS Proteins Protect Mitochondrial Genome Integrity by Interacting with Mitochondrial Single-stranded DNA-binding Protein

2009 ◽  
Vol 9 (1) ◽  
pp. 145-152 ◽  
Author(s):  
Marko Radulovic ◽  
Eleanor Crane ◽  
Mark Crawford ◽  
Jasminka Godovac-Zimmermann ◽  
Veronica P. C. C. Yu
Keyword(s):  
Dna Binding ◽  
Mitochondrial Genome ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Genome Integrity ◽  
Single Stranded Dna ◽  
Cks Proteins

scholarly journals The Cdk/Cdc14 Module Controls Activation of the Yen1 Holliday Junction Resolvase to Promote Genome Stability

2014 ◽  
Vol 54 (1) ◽  
pp. 80-93 ◽  
Author(s):  
Christie L. Eissler ◽  
Gerard Mazón ◽  
Brendan L. Powers ◽  
Sergey N. Savinov ◽  
Lorraine S. Symington ◽  
...  
Keyword(s):  
Genome Stability ◽  
Holliday Junction ◽  
Holliday Junction Resolvase
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