scholarly journals Rethinking the PDH Bypass and GABA Shunt as Thiamin-Deficiency Workarounds

2019 ◽  
Vol 181 (2) ◽  
pp. 389-393 ◽  
Author(s):  
Jaya Joshi ◽  
Jacob S. Folz ◽  
Jesse F. Gregory ◽  
Donald R. McCarty ◽  
Oliver Fiehn ◽  
...  
Keyword(s):  
Thiamin Deficiency ◽  
Gaba Shunt

scholarly journals Brain glutamate and γ-aminobutyrate (GABA) metabolism in thiamin-deficient rats

1989 ◽  
Vol 62 (2) ◽  
pp. 245-253 ◽  
Author(s):  
Martyn G. Page ◽  
Victor Ankoma-Sey ◽  
William F. Coulson ◽  
David A. Benders
Keyword(s):  
Metabolic Flux ◽  
Brain Metabolism ◽  
Considerable Increase ◽  
Specific Radioactivity ◽  
Intracerebroventricular Injection ◽  
Thiamin Deficiency ◽  
Gaba Shunt ◽  
Gaba Metabolism ◽  
Brain Gaba ◽  
The Brain

The brain metabolism of glutamate and γ-aminobutyrate (GABA) was investigated in thiamin-deficient and pair-fed control rats, in order to determine whether the GABA shunt may provide an important alternative to 2-oxo-glutarate dehydrogenase (EC 1.2.4.2) in energy-yielding metabolism in thiamin deficiency. Brains from thiamin-deficient animals contained less glutamate, 2-oxo-glutarate and GABA than those from control animals. The brain content of ATP was unaffected by thiamin deficiency. After intracerebroventricular injection of [14C]glutamate, the specific radioactivity of GABA in the brains from deficient animals was 45–50% higher than that in controls, suggesting a considerable increase in the metabolic flux through the GABA shunt in thiamin deficiency. Brain GABA showed a marked circumannual variation, with a peak in mid-summer and a minimum value in mid-winter.

Effects of thiamin deficiency on myocardial metabolism in intact dogs

1953 ◽  
Vol 46 (6) ◽  
pp. 883-894 ◽  
Author(s):  
Donald B. Hackel ◽  
Walter T. Goodale ◽  
Jerome Kleinerman
Keyword(s):  
Myocardial Metabolism ◽  
Thiamin Deficiency

Hypoxia and GABA shunt activation in the pathogenesis of Alzheimer's disease

2016 ◽  
Vol 92 ◽  
pp. 13-24 ◽  
Author(s):  
Antero Salminen ◽  
Paula Jouhten ◽  
Timo Sarajärvi ◽  
Annakaisa Haapasalo ◽  
Mikko Hiltunen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gaba Shunt

scholarly journals CARDIAC LESIONS IN THIAMIN DEFICIENCY

Heart ◽  
1948 ◽  
Vol 10 (4) ◽  
pp. 252-262 ◽  
Author(s):  
J. F. Pantridge
Keyword(s):  
Thiamin Deficiency ◽  
Cardiac Lesions

Alcohol and Cerebral Thiamin Deficiency

1982 ◽  
pp. 253-258 ◽  
Author(s):  
A. Stewart Truswell ◽  
Frank Apeagyei
Keyword(s):  
Thiamin Deficiency
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