scholarly journals Triphosphate Tunnel Metalloenzyme Function in Senescence Highlights a Biological Diversification of This Protein Superfamily

2017 ◽  
Vol 175 (1) ◽  
pp. 473-485 ◽  
Author(s):  
Huoi Ung ◽  
Purva Karia ◽  
Kazuo Ebine ◽  
Takashi Ueda ◽  
Keiko Yoshioka ◽  
...  
Keyword(s):  
Protein Superfamily ◽  
Triphosphate Tunnel Metalloenzyme

scholarly journals Plethodontid modulating factor, a hypervariable salamander courtship pheromone in the three-finger protein superfamily

FEBS Journal ◽  
2007 ◽  
Vol 274 (9) ◽  
pp. 2300-2310 ◽  
Author(s):  
Catherine A. Palmer ◽  
David M. Hollis ◽  
Richard A. Watts ◽  
Lynne D. Houck ◽  
Maureen A. McCall ◽  
...  
Keyword(s):  
Courtship Pheromone ◽  
Protein Superfamily ◽  
Finger Protein

Evolution of the SOUL Heme-Binding Protein Superfamily Across Eukarya

2016 ◽  
Vol 82 (6) ◽  
pp. 279-290 ◽  
Author(s):  
Antonio Emidio Fortunato ◽  
Paolo Sordino ◽  
Nikos Andreakis
Keyword(s):  
Binding Protein ◽  
Heme Binding ◽  
Protein Superfamily ◽  
Heme Binding Protein

scholarly journals Genome-Wide Collation of the Plasmodium falciparum WDR Protein Superfamily Reveals Malarial Parasite-Specific Features

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0128507 ◽  
Author(s):  
Priyanka Chahar ◽  
Manjeri Kaushik ◽  
Sarvajeet Singh Gill ◽  
Surendra Kumar Gakhar ◽  
Natrajan Gopalan ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Malarial Parasite ◽  
Protein Superfamily ◽  
Genome Wide

scholarly journals Phosphorylation of the mitochondrial triphosphate tunnel metalloenzyme TTM1 regulates programmed cell death in senescence

2020 ◽  
Author(s):  
Purva Karia ◽  
Keiko Yoshioka ◽  
Wolfgang Moeder
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Map Kinases ◽  
Mitochondrial Protein ◽  
Mitochondrial Outer Membrane ◽  
Mitogen Activated Protein ◽  
Animal Growth ◽  
Triphosphate Tunnel Metalloenzyme

ABSTRACTThe role of mitochondria in programmed cell death (PCD) during animal growth and development is well documented, but much less is known for plants. We previously showed that the Arabidopsis thaliana triphosphate tunnel metalloenzyme (TTM) proteins TTM1 and TTM2 are tail-anchored proteins that localize in the mitochondrial outer membrane and participate in PCD during senescence and immunity, respectively. Here, we show that TTM1 is specifically involved in senescence induced by abscisic acid (ABA). Moreover, phosphorylation of TTM1 by multiple mitogen-activated protein kinases (MAPKs) regulates its function and turnover. A combination of proteomics and in vitro kinase assays revealed three major phosphorylation sites of TTM1 (S10, S437, and S490), which are phosphorylated upon perception of senescence cues such as ABA and prolonged darkness. S437 is phosphorylated by the MAP kinases MPK3 and MPK4, and S437 phosphorylation is essential for TTM1 function in senescence. These MPKs, together with three additional MAP kinases (MPK1, MPK7, and MPK6), phosphorylate S10 and S490, marking TTM1 for protein turnover, which likely prevents uncontrolled cell death. Taken together, our results show that multiple MPKs regulate the function and turnover of the mitochondrial protein TTM1 during senescence-related PCD, revealing a novel link between mitochondria and PCD.SummaryEmail addresses: [email protected]

Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily

2016 ◽  
Vol 128 (28) ◽  
pp. 8062-8065 ◽  
Author(s):  
Ho Yeung ◽  
Christopher J. Squire ◽  
Yuliana Yosaatmadja ◽  
Santosh Panjikar ◽  
Gemma López ◽  
...  
Keyword(s):  
Radiation Damage ◽  
Protein Crystallography ◽  
Protein Superfamily ◽  
Unique Structure

scholarly journals The Small G Protein Superfamily Possible Functions and Modes of Action

1992 ◽  
Vol 38 (Special) ◽  
pp. 275-278
Author(s):  
K. KAIBUCHI ◽  
A. KIKUCHI ◽  
M. KAWATA ◽  
Y. TAKAI
Keyword(s):  
G Protein ◽  
Protein Superfamily ◽  
Modes Of Action ◽  
Small G Protein
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