scholarly journals Multiple Signaling Pathways in Gene Expression during Sugar Starvation. Pharmacological Analysis of din Gene Expression in Suspension-Cultured Cells of Arabidopsis

2000 ◽  
Vol 124 (3) ◽  
pp. 1139-1148 ◽  
Author(s):  
Yuki Fujiki ◽  
Masaki Ito ◽  
Ikuo Nishida ◽  
Akira Watanabe
Keyword(s):  
Gene Expression ◽  
Signaling Pathways ◽  
Cultured Cells ◽  
Sugar Starvation ◽  
Suspension Cultured Cells ◽  
Pharmacological Analysis ◽  
Multiple Signaling

scholarly journals Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts

2000 ◽  
Vol 10 (20) ◽  
pp. 1291-1294 ◽  
Author(s):  
Aurélio Balsalobre ◽  
Lysiane Marcacci ◽  
Ueli Schibler
Keyword(s):  
Gene Expression ◽  
Signaling Pathways ◽  
Circadian Gene ◽  
Multiple Signaling

scholarly journals Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy

PLoS Genetics ◽  
2022 ◽  
Vol 18 (1) ◽  
pp. e1010018
Author(s):  
Jianghong Cheng ◽  
Jia Liang ◽  
Yingzhe Li ◽  
Xia Gao ◽  
Mengjun Ji ◽  
...  
Keyword(s):  
Gene Expression ◽  
Signaling Pathways ◽  
Stromal Cells ◽  
Embryo Implantation ◽  
Endometrial Stromal Cells ◽  
Conditional Deletion ◽  
Enhancer Binding Protein ◽  
Epithelial Remodeling ◽  
Multiple Signaling ◽  
Transcription 3

Approximately 75% of failed pregnancies are considered to be due to embryo implantation failure or defects. Nevertheless, the explicit signaling mechanisms governing this process have not yet been elucidated. Here, we found that conditional deletion of the Shp2 gene in mouse uterine stromal cells deferred embryo implantation and inhibited the decidualization of stromal cells, which led to embryonic developmental delay and to the death of numerous embryos mid-gestation, ultimately reducing female fertility. The absence of Shp2 in stromal cells increased the proliferation of endometrial epithelial cells, thereby disturbing endometrial epithelial remodeling. However, Shp2 deletion impaired the proliferation and polyploidization of stromal cells, which are distinct characteristics of decidualization. In human endometrial stromal cells (hESCs), Shp2 expression gradually increased during the decidualization process. Knockout of Shp2 blocked the decidual differentiation of hESCs, while Shp2 overexpression had the opposite effect. Shp2 knockout inhibited the proliferation of hESCs during decidualization. Whole gene expression profiling analysis of hESCs during the decidualization process showed that Shp2 deficiency disrupted many signaling transduction pathways and gene expression. Analyses of hESCs and mouse uterine tissues confirmed that the signaling pathways extracellular regulated protein kinases (ERK), protein kinase B (AKT), signal transducer and activator of transcription 3 (STAT3) and their downstream transcription factors CCAAT/enhancer binding protein β (C/EBPβ) and Forkhead box transcription factor O1 (FOXO-1) were involved in the Shp2 regulation of decidualization. In summary, these results demonstrate that Shp2 plays a crucial role in stromal decidualization by mediating and coordinating multiple signaling pathways in uterine stromal cells. Our discovery possibly provides a novel key regulator of embryo implantation and novel therapeutic target for pregnancy failure.

scholarly journals Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes

2002 ◽  
Vol 99 (3) ◽  
pp. 1497-1502 ◽  
Author(s):  
H. Dadgostar ◽  
B. Zarnegar ◽  
A. Hoffmann ◽  
X.-F. Qin ◽  
U. Truong ◽  
...  
Keyword(s):  
Gene Expression ◽  
Signaling Pathways ◽  
B Lymphocytes ◽  
Regulated Gene Expression ◽  
Multiple Signaling

Elevation of Cytosolic Calcium Precedes Anoxic Gene Expression in Maize Suspension-Cultured Cells

1994 ◽  
Vol 6 (12) ◽  
pp. 1747 ◽  
Author(s):  
Chalivendra C. Subbaiah ◽  
Douglas S. Bush ◽  
Martin M. Sachs
Keyword(s):  
Gene Expression ◽  
Cultured Cells ◽  
Cytosolic Calcium ◽  
Suspension Cultured Cells
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