scholarly journals Importin [alpha] from Arabidopsis thaliana Is a Nuclear Import Receptor That Recognizes Three Classes of Import Signals

1997 ◽  
Vol 114 (2) ◽  
pp. 411-417 ◽  
Author(s):  
HMS. Smith ◽  
G. R. Hicks ◽  
N. V. Raikhel
Keyword(s):  
Arabidopsis Thaliana ◽  
Nuclear Import ◽  
Importin Alpha ◽  
Import Receptor

scholarly journals Structural Characterisation of the Nuclear Import Receptor Importin Alpha in Complex with the Bipartite NLS of Prp20

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e82038 ◽  
Author(s):  
Noelia Roman ◽  
Mary Christie ◽  
Crystall M. D. Swarbrick ◽  
Bostjan Kobe ◽  
Jade K. Forwood
Keyword(s):  
Nuclear Import ◽  
Structural Characterisation ◽  
Importin Alpha ◽  
Import Receptor

scholarly journals Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic

2016 ◽  
Vol 15 (4) ◽  
pp. 560-573 ◽  
Author(s):  
Pauline J. van der Watt ◽  
Alicia Chi ◽  
Tamara Stelma ◽  
Catherine Stowell ◽  
Erin Strydom ◽  
...  
Keyword(s):  
Nuclear Import ◽  
Import Receptor

scholarly journals Transportin Is a Major Nuclear Import Receptor for c-Fos

2006 ◽  
Vol 281 (9) ◽  
pp. 5492-5499 ◽  
Author(s):  
Marc Arnold ◽  
Annegret Nath ◽  
Daniel Wohlwend ◽  
Ralph H. Kehlenbach
Keyword(s):  
Nuclear Import ◽  
Import Receptor

scholarly journals The Requirement of H1 Histones for a Heterodimeric Nuclear Import Receptor

2002 ◽  
Vol 277 (36) ◽  
pp. 32480-32489 ◽  
Author(s):  
Marc Bäuerle ◽  
Detlef Doenecke ◽  
Werner Albig
Keyword(s):  
Nuclear Import ◽  
Import Receptor

scholarly journals The Chloroplast Import Receptor Toc90 Partially Restores the Accumulation of Toc159 Client Proteins in the Arabidopsis thaliana ppi2 Mutant

2011 ◽  
Vol 4 (2) ◽  
pp. 252-263 ◽  
Author(s):  
Sibylle Infanger ◽  
Sylvain Bischof ◽  
Andreas Hiltbrunner ◽  
Birgit Agne ◽  
Sacha Baginsky ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Chloroplast Import ◽  
Client Proteins ◽  
Import Receptor

scholarly journals Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites

Cell ◽  
2018 ◽  
Vol 173 (3) ◽  
pp. 693-705.e22 ◽  
Author(s):  
Takuya Yoshizawa ◽  
Rustam Ali ◽  
Jenny Jiou ◽  
Ho Yee Joyce Fung ◽  
Kathleen A. Burke ◽  
...  
Keyword(s):  
Phase Separation ◽  
Nuclear Import ◽  
Import Receptor

scholarly journals Nuclear Import Receptors and hnRNP K Mediates Nuclear and Stress Granule Localization of SIRLOIN

2021 ◽  
Author(s):  
Jialin Yao ◽  
Qiao Zhou ◽  
Hengyi Xiao ◽  
Da Jia ◽  
Qingxiang Sun
Keyword(s):  
Nuclear Import ◽  
Rna Binding ◽  
Weak Interactions ◽  
Underlying Mechanism ◽  
Stress Granule ◽  
Hnrnp K ◽  
Permeabilized Cells ◽  
Import Receptors ◽  
Rna Motif ◽  
Import Receptor

Abstract The majority of lncRNAs and a small fraction of mRNAs localize in the cell nucleus to exert their functions. A SIRLOIN RNA motif was previously reported to drive its nuclear localization by the RNA-binding protein hnRNP K. However, the underlying mechanism remains unclear. Here, we report crystal structures of hnRNP K in complex with SIRLOIN, and with the nuclear import receptor (NIR) Impα1, respectively. The protein hnRNP K bound to SIRLOIN with multiple weak interactions, and interacted Impα1 using an independent high-affinity site. Forming a complex with hnRNP K and Impα1 was essential for the nuclear and stress granule localization of SIRLOIN in semi-permeabilized cells. Nuclear import of SIRLOIN enhanced with increasing NIR concentrations, but its stress granule localization peaked at a low NIR concentration. Collectively, we propose a mechanism of SIRLOIN localization, in which NIRs functioned as drivers/regulators, and hnRNP K as an adaptor.

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