scholarly journals Conserved and Divergent Rhythms of Crassulacean Acid Metabolism-Related and Core Clock Gene Expression in the Cactus Opuntia ficus-indica

2011 ◽  
Vol 156 (4) ◽  
pp. 1978-1989 ◽  
Author(s):  
Izaskun Mallona ◽  
Marcos Egea-Cortines ◽  
Julia Weiss
Keyword(s):  
Gene Expression ◽  
Crassulacean Acid Metabolism ◽  
Clock Gene ◽  
Acid Metabolism ◽  
Opuntia Ficus Indica ◽  
Clock Gene Expression ◽  
Core Clock Gene

Hormonal regulation of core clock gene expression in skeletal muscle following acute aerobic exercise

2019 ◽  
Vol 508 (3) ◽  
pp. 871-876 ◽  
Author(s):  
Patrick G. Saracino ◽  
Michael L. Rossetti ◽  
Jennifer L. Steiner ◽  
Bradley S. Gordon
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Aerobic Exercise ◽  
Hormonal Regulation ◽  
Clock Gene ◽  
Clock Gene Expression ◽  
Core Clock Gene

scholarly journals Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Leonidas S. Lundell ◽  
Evelyn B. Parr ◽  
Brooke L. Devlin ◽  
Lars R. Ingerslev ◽  
Ali Altıntaş ◽  
...  
Keyword(s):  
Gene Expression ◽  
Amino Acid ◽  
Serum Lipids ◽  
Clock Gene ◽  
Energy Restriction ◽  
Restricted Feeding ◽  
Short Term ◽  
Macronutrient Composition ◽  
Clock Gene Expression ◽  
Core Clock Gene

Abstract Time-restricted feeding (TRF) improves metabolism independent of dietary macronutrient composition or energy restriction. To elucidate mechanisms underpinning the effects of short-term TRF, we investigated skeletal muscle and serum metabolic and transcriptomic profiles from 11 men with overweight/obesity after TRF (8 h day−1) and extended feeding (EXF, 15 h day−1) in a randomised cross-over design (trial registration: ACTRN12617000165381). Here we show that muscle core clock gene expression was similar after both interventions. TRF increases the amplitude of oscillating muscle transcripts, but not muscle or serum metabolites. In muscle, TRF induces rhythmicity of several amino acid transporter genes and metabolites. In serum, lipids are the largest class of periodic metabolites, while the majority of phase-shifted metabolites are amino acid related. In conclusion, short-term TRF in overweight men affects the rhythmicity of serum and muscle metabolites and regulates the rhythmicity of genes controlling amino acid transport, without perturbing core clock gene expression.

scholarly journals MicroRNAs modulate core-clock gene expression in pancreatic islets during early postnatal life in rats

Diabetologia ◽  
2017 ◽  
Vol 60 (10) ◽  
pp. 2011-2020 ◽  
Author(s):  
Cécile Jacovetti ◽  
Adriana Rodriguez-Trejo ◽  
Claudiane Guay ◽  
Jonathan Sobel ◽  
Sonia Gattesco ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pancreatic Islets ◽  
Clock Gene ◽  
Postnatal Life ◽  
Clock Gene Expression ◽  
Early Postnatal Life ◽  
Core Clock Gene

scholarly journals Diurnal variations in the expression of core-clock genes correlate with resting muscle properties and predict fluctuations in exercise performance across the day

2021 ◽  
Vol 7 (1) ◽  
pp. e000876
Author(s):  
Alireza Basti ◽  
Müge Yalçin ◽  
David Herms ◽  
Janina Hesse ◽  
Ouda Aboumanify ◽  
...  
Keyword(s):  
Gene Expression ◽  
Exercise Performance ◽  
Clock Gene ◽  
Clock Genes ◽  
Muscle Tone ◽  
Muscle Properties ◽  
Clock Gene Expression ◽  
Digital Palpation ◽  
Resting Muscle ◽  
Core Clock Gene

ObjectivesIn this study, we investigated daily fluctuations in molecular (gene expression) and physiological (biomechanical muscle properties) features in human peripheral cells and their correlation with exercise performance.Methods21 healthy participants (13 men and 8 women) took part in three test series: for the molecular analysis, 15 participants provided hair, blood or saliva time-course sampling for the rhythmicity analysis of core-clock gene expression via RT-PCR. For the exercise tests, 16 participants conducted strength and endurance exercises at different times of the day (9h, 12h, 15h and 18h). Myotonometry was carried out using a digital palpation device (MyotonPRO), five muscles were measured in 11 participants. A computational analysis was performed to relate core-clock gene expression, resting muscle tone and exercise performance.ResultsCore-clock genes show daily fluctuations in expression in all biological samples tested for all participants. Exercise performance peaks in the late afternoon (15–18 hours for both men and women) and shows variations in performance, depending on the type of exercise (eg, strength vs endurance). Muscle tone varies across the day and higher muscle tone correlates with better performance. Molecular daily profiles correlate with daily variation in exercise performance.ConclusionTraining programmes can profit from these findings to increase efficiency and fine-tune timing of training sessions based on the individual molecular data. Our results can benefit both professional athletes, where a fraction of seconds may allow for a gold medal, and rehabilitation in clinical settings to increase therapy efficacy and reduce recovery times.

scholarly journals Mammary core clock gene expression is impacted by photoperiod exposure during the dry period in goats

2018 ◽  
Vol 46 (1) ◽  
pp. 1214-1219 ◽  
Author(s):  
Theresa M. Casey ◽  
Karen Plaut ◽  
Mugagga Kalyesubula ◽  
Avi Shamay ◽  
Chris Sabastian ◽  
...  
Keyword(s):  
Gene Expression ◽  
Clock Gene ◽  
Dry Period ◽  
Clock Gene Expression ◽  
Core Clock Gene

scholarly journals Western diet-induced obesity disrupts the diurnal rhythmicity of hippocampal core clock gene expression in a mouse model

2020 ◽  
Vol 88 ◽  
pp. 815-825 ◽  
Author(s):  
Lauren N. Woodie ◽  
Robert M. Johnson ◽  
Bulbul Ahmed ◽  
Savanah Fowler ◽  
William Haynes ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
Clock Gene ◽  
Western Diet ◽  
Clock Gene Expression ◽  
Diet Induced Obesity ◽  
Core Clock Gene ◽  
Diurnal Rhythmicity

scholarly journals Time of Day Dependent Effects of Contractile Activity on the Phase of the Skeletal Muscle Clock

2020 ◽  
Author(s):  
Denise Kemler ◽  
Christopher A. Wolff ◽  
Karyn A. Esser
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Circadian Clock ◽  
Clock Gene ◽  
Treadmill Exercise ◽  
Contractile Activity ◽  
Phase Changes ◽  
Phase Advance ◽  
Clock Gene Expression ◽  
Core Clock Gene

ABSTRACTExercise has been proposed to be a zeitgeber for the muscle circadian clock mechanism. However, this is not well defined and it is unknown if exercise timing induces directional shifts of the muscle clock. Our purpose herein was to assess the effect of one bout of treadmill exercise on skeletal muscle clock phase changes. We subjected PERIOD2::LUCIFERASE mice (n=30F) to one 60-minute treadmill exercise bout at three times of day. Exercise at ZT5, 5h after lights on, induced a phase advance (1.4±0.53h; p=0.038), whereas exercise at ZT11, 1h before lights off, induced a phase delay (−0.95±0.43h; p=0.0315). Exercise at ZT17, middle of the dark phase, did not alter muscle clock phase. Exercise induces diverse systemic changes so we developed an in-vitro model system to examine effects of contractile activity on muscle clock phase. Contractions applied at peak or trough Bmal1 expression induced significant phase delays (applied at peak: 1.3±0.02h; p=0.0425; applied at trough: 1.8±0.02h, p=0.0074). Contractions applied during the transition from peak to trough Bmal1 expression induced a phase advance (1.8±0.03h; p=0.0265). Lastly, contractions at different times of day resulted in differential changes of core-clock gene expression demonstrating an exercise and clock interaction, providing insight into potential mechanisms exercise-induced phase shifts. These data demonstrate that muscle contractions, as part of exercise, are sufficient to shift muscle circadian clock phase, likely through changes in core-clock gene expression. Additionally, our findings that exercise induces directional muscle clock phase changes confirms exercise is a bone fide environmental time cue for skeletal muscle.

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