scholarly journals Dynamic Proteomic Analysis Reveals a Switch between Central Carbon Metabolism and Alcoholic Fermentation in Rice Filling Grains

2008 ◽  
Vol 148 (2) ◽  
pp. 908-925 ◽  
Author(s):  
Sheng Bao Xu ◽  
Tang Li ◽  
Zhu Yun Deng ◽  
Kang Chong ◽  
Yongbiao Xue ◽  
...  
Keyword(s):  
Carbon Metabolism ◽  
Proteomic Analysis ◽  
Alcoholic Fermentation ◽  
Central Carbon Metabolism ◽  
Central Carbon

scholarly journals Evidence for loss and adaptive reacquisition of alcoholic fermentation in an early-derived fructophilic yeast lineage

2017 ◽  
Author(s):  
Carla Gonçalves ◽  
Jennifer H. Wisecaver ◽  
Madalena Salema-Oom ◽  
Maria José Leandro ◽  
Xing-Xing Shen ◽  
...  
Keyword(s):  
Comparative Genomics ◽  
Gene Transfer ◽  
Horizontal Gene Transfer ◽  
Carbon Metabolism ◽  
Alcoholic Fermentation ◽  
Carbon Sources ◽  
Central Carbon Metabolism ◽  
High Sugar ◽  
Central Carbon ◽  
Adaptive Nature

AbstractFructophily is a rare trait that consists in the preference for fructose over other carbon sources. Here we show that in a yeast lineage (theWickerhamiella/Starmerella, W/S clade) formed by fructophilic species thriving in the floral niche, the acquisition of fructophily is part of a wider process of adaptation of central carbon metabolism to the high sugar environment. Coupling comparative genomics with biochemical and genetic approaches, we show that the alcoholic fermentation pathway was profoundly remodeled in the W/S clade, as genes required for alcoholic fermentation were lost and subsequently re-acquired from bacteria through horizontal gene transfer. We further show that the reinstated fermentative pathway is functional and that an enzyme required for sucrose assimilation is also of bacterial origin, reinforcing the adaptive nature of the genetic novelties identified in the W/S clade. This work shows how even central carbon metabolism can be remodeled by a surge of HGT events.

scholarly journals Evidence for loss and reacquisition of alcoholic fermentation in a fructophilic yeast lineage

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Carla Gonçalves ◽  
Jennifer H Wisecaver ◽  
Jacek Kominek ◽  
Madalena Salema Oom ◽  
Maria José Leandro ◽  
...  
Keyword(s):  
Carbon Metabolism ◽  
Alcoholic Fermentation ◽  
Carbon Sources ◽  
Central Carbon Metabolism ◽  
Yeast Gene ◽  
Ample Evidence ◽  
High Sugar ◽  
Central Carbon ◽  
Bacterial Genes ◽  
Horizontal Acquisition

Fructophily is a rare trait that consists of the preference for fructose over other carbon sources. Here, we show that in a yeast lineage (the Wickerhamiella/Starmerella, W/S clade) comprised of fructophilic species thriving in the high-sugar floral niche, the acquisition of fructophily is concurrent with a wider remodeling of central carbon metabolism. Coupling comparative genomics with biochemical and genetic approaches, we gathered ample evidence for the loss of alcoholic fermentation in an ancestor of the W/S clade and subsequent reinstatement through either horizontal acquisition of homologous bacterial genes or modification of a pre-existing yeast gene. An enzyme required for sucrose assimilation was also acquired from bacteria, suggesting that the genetic novelties identified in the W/S clade may be related to adaptation to the high-sugar environment. This work shows how even central carbon metabolism can be remodeled by a surge of HGT events.

scholarly journals Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers

2016 ◽  
Vol 24 (5) ◽  
pp. 728-739 ◽  
Author(s):  
Xiaojing Liu ◽  
Iris L. Romero ◽  
Lacey M. Litchfield ◽  
Ernst Lengyel ◽  
Jason W. Locasale
Keyword(s):  
Carbon Metabolism ◽  
Central Carbon Metabolism ◽  
Human Cancers ◽  
Central Carbon

Trisomy 21 results in modest impacts on mitochondrial function and central carbon metabolism

2021 ◽  
Author(s):  
Colin C. Anderson ◽  
John O. Marentette ◽  
Kendra M. Prutton ◽  
Abhishek K. Rauniyar ◽  
Julie A. Reisz ◽  
...  
Keyword(s):  
Mitochondrial Function ◽  
Carbon Metabolism ◽  
Trisomy 21 ◽  
Central Carbon Metabolism ◽  
Central Carbon

Metabolic phenotyping of the Yersinia high-pathogenicity island that regulates central carbon metabolism

The Analyst ◽  
2015 ◽  
Vol 140 (10) ◽  
pp. 3356-3361 ◽  
Author(s):  
Leyu Yan ◽  
Wenna Nie ◽  
Haitao Lv
Keyword(s):  
Carbon Metabolism ◽  
Virulence Genes ◽  
Pathogenicity Island ◽  
Central Carbon Metabolism ◽  
Metabolic Phenotyping ◽  
High Pathogenicity ◽  
Central Carbon ◽  
Regulatory Effects

The regulatory effects of the HPI virulence genes on central carbon metabolism differentiate UPEC from non-UPEC.

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