scholarly journals Global Analysis of Arabidopsis Gene Expression Uncovers a Complex Array of Changes Impacting Pathogen Response and Cell Cycle during Geminivirus Infection

2008 ◽  
Vol 148 (1) ◽  
pp. 436-454 ◽  
Author(s):  
José Trinidad Ascencio-Ibáñez ◽  
Rosangela Sozzani ◽  
Tae-Jin Lee ◽  
Tzu-Ming Chu ◽  
Russell D. Wolfinger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Global Analysis ◽  
Arabidopsis Gene ◽  
Pathogen Response

scholarly journals Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks

2003 ◽  
Vol 261 (1) ◽  
pp. 165-182 ◽  
Author(s):  
Stanislav L Karsten ◽  
Lili C Kudo ◽  
Robert Jackson ◽  
Chiara Sabatti ◽  
Harley I Kornblum ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Metabolic Networks ◽  
Global Analysis ◽  
Neural Progenitors ◽  
Specific Cell ◽  
Cell Cycle Signaling

scholarly journals Global analysis of cell cycle gene expression of the legume symbiontSinorhizobium meliloti

2014 ◽  
Vol 111 (9) ◽  
pp. 3217-3224 ◽  
Author(s):  
Nicole J. De Nisco ◽  
Ryan P. Abo ◽  
C. Max Wu ◽  
Jon Penterman ◽  
Graham C. Walker
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Global Analysis ◽  
Cell Cycle Gene ◽  
Cell Cycle Gene Expression

scholarly journals Global analysis of phase locking in gene expression during cell cycle: the potential in network modeling

2010 ◽  
Vol 4 (1) ◽  
pp. 167 ◽  
Author(s):  
Shouguo Gao ◽  
John L Hartman IV ◽  
Justin L Carter ◽  
Martin J Hessner ◽  
Xujing Wang
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Global Analysis ◽  
Phase Locking ◽  
Network Modeling

Ethanol alters cell cycle gene expression in human embryonic stem cells

2016 ◽  
Vol 01 (03) ◽  
pp. 201-208 ◽  
Author(s):  
Malini Krishnamoorthy ◽  
Brian Gerwe ◽  
Jamie Heimburg-Molinaro ◽  
Rachel Nash ◽  
Jagan Arumugham ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cell Cycle Gene ◽  
Cell Cycle Gene Expression

Reverse Screening Bioinformatics Approach to Identify Potential Anti Breast Cancer Targets Using Thymoquinone from Neutraceuticals Black Cumin Oil

2019 ◽  
Vol 19 (5) ◽  
pp. 599-609 ◽  
Author(s):  
Sumathi Sundaravadivelu ◽  
Sonia K. Raj ◽  
Banupriya S. Kumar ◽  
Poornima Arumugamand ◽  
Padma P. Ragunathan
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cell Cycle ◽  
Cell Death ◽  
In Silico ◽  
Chemotherapeutic Agents ◽  
Normal Cells ◽  
Black Cumin ◽  
In Silico Docking ◽  
Wide Range

Background: Functional foods, neutraceuticals and natural antioxidants have established their potential roles in the protection of human health and diseases. Thymoquinone (TQ), the main bioactive component of Nigella sativa seeds (black cumin seeds), a plant derived neutraceutical was used by ancient Egyptians because of their ability to cure a variety of health conditions and used as a dietary food supplement. Owing to its multi targeting nature, TQ interferes with a wide range of tumorigenic processes and counteracts carcinogenesis, malignant growth, invasion, migration, and angiogenesis. Additionally, TQ can specifically sensitize tumor cells towards conventional cancer treatments (e.g., radiotherapy, chemotherapy, and immunotherapy) and simultaneously minimize therapy-associated toxic effects in normal cells besides being cost effective and safe. TQ was found to play a protective role when given along with chemotherapeutic agents to normal cells. Methods: In the present study, reverse in silico docking approach was used to search for potential molecular targets for cancer therapy. Various metastatic and apoptotic targets were docked with the target ligand. TQ was also tested for its anticancer activities for its ability to cause cell death, arrest cell cycle and ability to inhibit PARP gene expression. Results: In silico docking studies showed that TQ effectively docked metastatic targets MMPs and other apoptotic and cell proliferation targets EGFR. They were able to bring about cell death mediated by apoptosis, cell cycle arrest in the late apoptotic stage and induce DNA damage too. TQ effectively down regulated PARP gene expression which can lead to enhanced cancer cell death. Conclusion: Thymoquinone a neutraceutical can be employed as a new therapeutic agent to target triple negative breast cancer which is otherwise difficult to treat as there are no receptors on them. Can be employed along with standard chemotherapeutic drugs to treat breast cancer as a combinatorial therapy.

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