scholarly journals Identification of a Cell Cycle-Related Gene, Cyclin, in Nicotiana tabacum (L.)

1995 ◽  
Vol 108 (1) ◽  
pp. 425-426 ◽  
Author(s):  
L. X. Qin ◽  
L. Richard ◽  
C. Perennes ◽  
P. Gadal ◽  
C. Bergounioux
Keyword(s):  
Cell Cycle ◽  
Nicotiana Tabacum ◽  
Related Gene ◽  
Nicotiana Tabacum L ◽  
Cell Cycle Related Gene ◽  
A Cell

scholarly journals Analysis of cell cycle related gene expression in Myb deficient mandible – a pilot study

Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 100907
Author(s):  
Sabina Stouracova ◽  
Eva Matalova ◽  
Jon Frampton ◽  
Mary Clarke ◽  
Premysl Bartos ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Pilot Study ◽  
Related Gene ◽  
Cell Cycle Related Gene

scholarly journals Circ_0084927 promotes cervical carcinogenesis by sponging miR-1179 that suppresses CDK2, a cell cycle-related gene

2020 ◽  
Author(s):  
Xinhua Qu ◽  
Liumei Zhu ◽  
Linlin Song ◽  
Shaohua Liu
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Regulatory Network ◽  
Inhibitory Effect ◽  
Cervical Carcinogenesis ◽  
Activation Assay ◽  
Cell Cycle Related Gene ◽  
Rna Immunoprecipitation ◽  
A Cell ◽  
Brdu Assay

Abstract Background: Cervical cancer (CC) is a highly malignant tumor. Evolving researches on CC have unveiled a concept that circRNA exerts important roles in CC progression. In this study, we mainly explored the role of a novel circRNA, circ_0084927, and its regulatory network in the development of CC.Methods: qRT-PCR was applied to evaluate the expression of circ_0084927, miR-1179 and CDK2 mRNA in CC tissues and cells. Dual-luciferase reporting experiments and RNA immunoprecipitation (RIP) assay were conducted to validate the target relationship of miR-1179 with circ_0084927 and CDK2 mRNA. CCK-8 and BrdU assay was used to evaluate CC cell proliferation. The adhesion and apoptosis phenotypes of CC cells were measured by cell-matrix adhesion and caspase 3 activation assay. Flow cytometry was employed to detect CC cell cycle.Results: Our results indicated that circ_0084927 was up-regulated in CC tissues and cells, and circ_0084927 silence inhibited CC cell proliferation and adhesion, while facilitating apoptosis as well as triggering cell cycle arrest. On the other hand, miR-1179 down-regulation appeared in CC tissues. Additionally, circ_0084927 abolished miR-1179’s inhibitory effects on cell proliferation and adhesion. Our study showed that CDK2 was up-regulated in CC tissues and played a cancer-promoting role. Furthermore, miR-1179 directly targeted CDK2, thereby inhibiting CDK2’s promotion on the malignant phenotypes of CC cells. circ_0084927 revoked the inhibitory effect of miR-1179 on CDK2 by sponging miR-1179.Conclusion: Circ_0084927 promoted cervical carcinogenesis by sequestering miR-1179 that directly targeted CDK2. Our results shed light on the circ_0084927/miR-1179/CDK2 regulatory network that strengthened CC aggressiveness, providing novel candidate targets for CC treatment.

Core Cell Cycle–Related Gene Identification and Expression Analysis in Maize

2020 ◽  
Author(s):  
Qianlin Xiao ◽  
Bin Wei ◽  
Yayun Wang ◽  
Hui Li ◽  
Huanhuan Huang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Expression Analysis ◽  
Gene Identification ◽  
Related Gene ◽  
Cell Cycle Related Gene

scholarly journals DEPDC1 is a novel cell cycle related gene that regulates mitotic progression

BMB Reports ◽  
2015 ◽  
Vol 48 (7) ◽  
pp. 413-418 ◽  
Author(s):  
Yan Mi ◽  
Chundong Zhang ◽  
Youquan Bu ◽  
Ying Zhang ◽  
Longxia He ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Related Gene ◽  
Mitotic Progression ◽  
Cell Cycle Related Gene

HepG2 cell cycle related gene transcriptional profiles are altered by a novel vanillin derivative BVAN08

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Bo Zhang ◽  
◽  
Pingkun Zhou ◽  
Lantao Liu ◽  
Hua Guan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Hepg2 Cell ◽  
Related Gene ◽  
Transcriptional Profiles ◽  
Cell Cycle Related Gene
Sign in / Sign up

Export Citation Format

Share Document