scholarly journals Chemical Genetic Identification of Glutamine Phosphoribosylpyrophosphate Amidotransferase as the Target for a Novel Bleaching Herbicide in Arabidopsis

2007 ◽  
Vol 144 (3) ◽  
pp. 1292-1304 ◽  
Author(s):  
Terence A. Walsh ◽  
Teresa Bauer ◽  
Roben Neal ◽  
Ann Owens Merlo ◽  
Paul R. Schmitzer ◽  
...  
Keyword(s):  
Genetic Identification ◽  
Chemical Genetic ◽  
Phosphoribosylpyrophosphate Amidotransferase ◽  
Bleaching Herbicide

scholarly journals Chemical genetic identification of CDKL 5 substrates reveals its role in neuronal microtubule dynamics

2018 ◽  
Vol 37 (24) ◽  
Author(s):  
Lucas L Baltussen ◽  
Priscilla D Negraes ◽  
Margaux Silvestre ◽  
Suzanne Claxton ◽  
Max Moeskops ◽  
...  
Keyword(s):  
Microtubule Dynamics ◽  
Genetic Identification ◽  
Chemical Genetic

scholarly journals Chemical Genetic Identification of the IGF-Linked Pathway that Is Mediated by STAT6 and MFP2

2006 ◽  
Vol 13 (3) ◽  
pp. 241-249 ◽  
Author(s):  
Yongmun Choi ◽  
Hiroki Shimogawa ◽  
Koji Murakami ◽  
Latha Ramdas ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Genetic Identification ◽  
Chemical Genetic

scholarly journals Chemical genetic identification of a lectin receptor kinase that transduces immune responses and interferes with abscisic acid signaling

2019 ◽  
Vol 98 (3) ◽  
pp. 492-510 ◽  
Author(s):  
Jiyoung Park ◽  
Tae‐Houn Kim ◽  
Yohei Takahashi ◽  
Rebecca Schwab ◽  
Keini Dressano ◽  
...  
Keyword(s):  
Abscisic Acid ◽  
Immune Responses ◽  
Genetic Identification ◽  
Receptor Kinase ◽  
Chemical Genetic ◽  
Lectin Receptor ◽  
Abscisic Acid Signaling

scholarly journals Chemical genetic identification of GAK substrates reveals its role in regulating Na+/K+-ATPase

2018 ◽  
Vol 1 (6) ◽  
pp. e201800118 ◽  
Author(s):  
Amy W Lin ◽  
Kalbinder K Gill ◽  
Marisol Sampedro Castañeda ◽  
Irene Matucci ◽  
Noreen Eder ◽  
...  
Keyword(s):  
Pyramidal Neurons ◽  
Association Studies ◽  
Conditional Knockout ◽  
Genetic Identification ◽  
Resting Membrane Potential ◽  
Genome Wide Association Studies ◽  
Α Subunit ◽  
Chemical Genetic ◽  
Whole Cell Patch Clamp ◽  
Cyclin G

Cyclin G–associated kinase (GAK) is a ubiquitous serine/threonine kinase that facilitates clathrin uncoating during vesicle trafficking. GAK phosphorylates a coat adaptor component, AP2M1, to help achieve this function. GAK is also implicated in Parkinson's disease through genome-wide association studies. However, GAK's role in mammalian neurons remains unclear, and insight may come from identification of further substrates. Employing a chemical genetics method, we show here that the sodium potassium pump (Na+/K+-ATPase) α-subunit Atp1a3 is a GAK target and that GAK regulates Na+/K+-ATPase trafficking to the plasma membrane. Whole-cell patch clamp recordings from CA1 pyramidal neurons in GAK conditional knockout mice show a larger change in resting membrane potential when exposed to the Na+/K+-ATPase blocker ouabain, indicating compromised Na+/K+-ATPase function in GAK knockouts. Our results suggest a modulatory role for GAK via phosphoregulation of substrates such as Atp1a3 during cargo trafficking.

scholarly journals Chemical-genetic identification of the biochemical targets of polyalkyl guanidinium biocides

2013 ◽  
Vol 11 (26) ◽  
pp. 4359 ◽  
Author(s):  
Drew Bowie ◽  
Paria Parvizi ◽  
Dustin Duncan ◽  
Christopher J. Nelson ◽  
Thomas M. Fyles
Keyword(s):  
Genetic Identification ◽  
Chemical Genetic

scholarly journals Chemical Genetic Identification of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development

Neuron ◽  
2012 ◽  
Vol 73 (6) ◽  
pp. 1127-1142 ◽  
Author(s):  
Sila K. Ultanir ◽  
Nicholas T. Hertz ◽  
Guangnan Li ◽  
Woo-Ping Ge ◽  
Alma L. Burlingame ◽  
...  
Keyword(s):  
Genetic Identification ◽  
Chemical Genetic ◽  
Spine Development ◽  
Kinase Substrates
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