scholarly journals Cloning and Characterization of Unusual Fatty Acid Desaturases from Anemone leveillei: Identification of an Acyl-Coenzyme A C20 Δ5-Desaturase Responsible for the Synthesis of Sciadonic Acid

2007 ◽  
Vol 144 (1) ◽  
pp. 455-467 ◽  
Author(s):  
Olga Sayanova ◽  
Richard Haslam ◽  
Monica Venegas Caleron ◽  
Johnathan A. Napier
Keyword(s):  
Fatty Acid ◽  
Coenzyme A ◽  
Unusual Fatty Acid ◽  
Fatty Acid Desaturases ◽  
Sciadonic Acid ◽  
Δ5 Desaturase ◽  
Acyl Coenzyme A

scholarly journals Fatty Acid Export from the Chloroplast. Molecular Characterization of a Major Plastidial Acyl-Coenzyme A Synthetase from Arabidopsis

2002 ◽  
Vol 129 (4) ◽  
pp. 1700-1709 ◽  
Author(s):  
Judy A. Schnurr ◽  
Jay M. Shockey ◽  
Gert-Jan de Boer ◽  
John A. Browse
Keyword(s):  
Fatty Acid ◽  
Molecular Characterization ◽  
Coenzyme A ◽  
Acyl Coenzyme A

scholarly journals Mouse Cardiac Acyl Coenzyme A Synthetase 1 Deficiency Impairs Fatty Acid Oxidation and Induces Cardiac Hypertrophy

2011 ◽  
Vol 31 (6) ◽  
pp. 1252-1262 ◽  
Author(s):  
J. M. Ellis ◽  
S. M. Mentock ◽  
M. A. DePetrillo ◽  
T. R. Koves ◽  
S. Sen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cardiac Hypertrophy ◽  
Fatty Acid Oxidation ◽  
Coenzyme A ◽  
Acid Oxidation ◽  
Acyl Coenzyme A

scholarly journals Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold

2000 ◽  
Vol 19 (19) ◽  
pp. 5167-5177 ◽  
Author(s):  
D.M.F van Aalten ◽  
C.C. DiRusso ◽  
J. Knudsen ◽  
R.K. Wierenga
Keyword(s):  
Crystal Structure ◽  
Transcription Factor ◽  
Fatty Acid ◽  
Coenzyme A ◽  
Acyl Coenzyme A

Glucose-6-phosphate dehydrogenase from Neisseria gonorrhoeae: partial characterization of the enzyme and inhibition by long-chain fatty acid acyl-coenzyme A derivatives

1980 ◽  
Vol 26 (8) ◽  
pp. 863-873 ◽  
Author(s):  
Anthony F. Cacciapuoti ◽  
Stephen A. Morse
Keyword(s):  
Fatty Acid ◽  
Neisseria Gonorrhoeae ◽  
Coenzyme A ◽  
Energy Charge ◽  
Chain Fatty Acid ◽  
Adenylate Energy Charge ◽  
Long Chain Fatty Acid ◽  
Acyl Coenzyme A ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Long Chain

The glucose-6-phosphate dehydrogenase from Neisseria gonorrhoeae was inhibited by long-chain fatty acid acyl-coenzyme A derivatives. The inhibition was increased at low concentrations of glucose 6-phosphate and was greater with the NAD-linked activity (ca. 0.05 mM inhibitor required for 50% inhibition) than with the NADP-linked activity (ca. 0.2 mM required for 50% inhibition). Bovine serum albumin and spermine could prevent the inhibition by the acyl-coenzyme A derivatives, but neither of these compounds nor high concentrations of cofactors or substrate could reverse the effect. Dilution of enzyme–inhibitor preincubation mixtures appeared to reverse the inhibition. The inhibition by stearoyl-coenzyme A was of the mixed type, and the inhibitor appeared to have a greater affinity for the free enzyme (Ki = 0.016–0.05 mM) than for enzyme bound to cofactor or substrate (Kis = 0.07–0.08 mM). Glucose-6-phosphate dehydrogenase activity was also inhibited competitively by adenosine 5′-triphosphate and was strongly regulated by adenylate energy charge values between 0.9 and 1.0. Kinetic and other characteristics of the enzyme are presented, and the possible role of glucose-6-phosphate dehydrogenase as a target for fatty acid toxicity in gonococci, mediated in the form of the acyl-coenzyme A derivatives, is discussed.

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