scholarly journals Distribution of Pyruvate Dehydrogenase Complex Activities between Chloroplasts and Mitochondria from Leaves of Different Species

1994 ◽  
Vol 106 (4) ◽  
pp. 1633-1638 ◽  
Author(s):  
U. Lernmark ◽  
P. Gardestrom
Keyword(s):  
Pyruvate Dehydrogenase ◽  
Pyruvate Dehydrogenase Complex ◽  
Complex Activities ◽  
Dehydrogenase Complex

scholarly journals The relationship between changes in lipid fuel availability and tissue fructose 2,6-bisphosphate concentrations and pyruvate dehydrogenase complex activities in the fed state

1988 ◽  
Vol 256 (3) ◽  
pp. 935-939 ◽  
Author(s):  
T J French ◽  
A W Goode ◽  
M J Holness ◽  
P A MacLennan ◽  
M C Sugden
Keyword(s):  
Fatty Acids ◽  
Pyruvate Dehydrogenase ◽  
Surgical Stress ◽  
Pyruvate Dehydrogenase Complex ◽  
Elevated Concentration ◽  
Fed State ◽  
Esterified Fatty Acids ◽  
The Relationship ◽  
Complex Activities ◽  
Dehydrogenase Complex

An elevated concentration of non-esterified fatty acids in the fed state elicited inhibition of cardiac, but not hepatic, pyruvate dehydrogenase complex (PDH). There was a modest decline in fructose 2,6-bisphosphate (Fru-2,6-P2) concentration in heart, and, to a lesser extent, in liver. Surgical stress decreased PDH activities and Fru-2,6-P2 concentrations in both heart and liver. Only the former response was abolished if postoperative lipolysis was inhibited. Surgery also decreased the [Fru-2,6-P2] in gastrocnemius: this response was abolished if lipolysis was inhibited.

scholarly journals Effects of administration of tri-iodothyronine on the response of cardiac and renal pyruvate dehydrogenase complex to starvation for 48 h

1985 ◽  
Vol 232 (1) ◽  
pp. 255-259 ◽  
Author(s):  
M J Holness ◽  
T N Palmer ◽  
M C Sugden
Keyword(s):  
Fatty Acids ◽  
Steady State ◽  
Fatty Acid ◽  
Pyruvate Dehydrogenase ◽  
Ketone Body ◽  
Ketone Bodies ◽  
Pyruvate Dehydrogenase Complex ◽  
Active Form ◽  
Complex Activities ◽  
Dehydrogenase Complex

Effects of administration of tri-iodothyronine (T3) on activities of cardiac and renal pyruvate dehydrogenase complex (active form, PDHa) were investigated. In fed rats, T3 treatment did not affect cardiac or renal PDHa activity, although blood non-esterified fatty acid and ketone-body concentrations were increased. Starvation (48 h) of both control and T3-treated rats resulted in similar increases in the steady-state concentrations of fatty acids and ketone bodies, but inactivation of cardiac and renal pyruvate dehydrogenase complex activities was diminished by T3 treatment. Inhibition of lipolysis increased renal and cardiac PDHa in control but not in T3-treated 48 h-starved rats, despite decreased fatty acid and ketone-body concentrations in both groups. The results suggest that hyperthyroidism influences the response of cardiac and renal PDHa activities to starvation through changes in the metabolism of lipid fuels in these tissues.

scholarly journals Pyruvate dehydrogenase activities during the fed-to-starved transition and on re-feeding after acute or prolonged starvation

1989 ◽  
Vol 258 (2) ◽  
pp. 529-533 ◽  
Author(s):  
M J Holness ◽  
M C Sugden
Keyword(s):  
Acute Phase ◽  
Pyruvate Dehydrogenase ◽  
Temporal Relationship ◽  
Pyruvate Dehydrogenase Complex ◽  
Hepatic Glycogen ◽  
Dietary Carbohydrate ◽  
Glycogen Depletion ◽  
Prolonged Starvation ◽  
Complex Activities ◽  
Dehydrogenase Complex

We investigated the temporal relationship between hepatic glycogen depletion and cardiac and hepatic PDH (pyruvate dehydrogenase complex) activities during the acute phase of starvation. There was a striking correlation between the decline in hepatic glycogen and PDH inactivation during the first 10 h of starvation. Re-feeding after 6 h starvation was associated with complete re-activation of PDH in liver and re-activation to approx. 75% of the fed value in heart, whereas in rats previously starved for 24-48 h re-activation was delayed in liver and diminished in heart. The results are discussed with reference to the fate of dietary carbohydrate after re-feeding.

The Pyruvate Dehydrogenase Complex as a Target for Gene Therapy

2003 ◽  
Vol 3 (3) ◽  
pp. 239-245 ◽  
Author(s):  
Peter Stacpoole ◽  
Renius Owen ◽  
Terence Flotte
Keyword(s):  
Gene Therapy ◽  
Pyruvate Dehydrogenase ◽  
Pyruvate Dehydrogenase Complex ◽  
Dehydrogenase Complex
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