scholarly journals Molecular Modeling and Site-Directed Mutagenesis Reveal the Benzylisoquinoline Binding Site of the Short-Chain Dehydrogenase/Reductase Salutaridine Reductase

2007 ◽  
Vol 143 (4) ◽  
pp. 1493-1503 ◽  
Author(s):  
René Geissler ◽  
Wolfgang Brandt ◽  
Jörg Ziegler
Keyword(s):  
Molecular Modeling ◽  
Binding Site ◽  
Site Directed Mutagenesis ◽  
Short Chain ◽  
Directed Mutagenesis ◽  
Short Chain Dehydrogenase

Combination of Molecular Modeling, Site-Directed Mutagenesis, and SAR Studies To Delineate the Binding Site of Pyridopyrimidine Antagonists on the Human CCK1 Receptor

2005 ◽  
Vol 48 (15) ◽  
pp. 4842-4850 ◽  
Author(s):  
Mercedes Martín-Martínez ◽  
Anne Marty ◽  
Maud Jourdan ◽  
Chantal Escrieut ◽  
Elodie Archer ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Binding Site ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Sar Studies ◽  
Cck1 Receptor

ATP-Binding Site of Human Brain Hexokinase As Studied by Molecular Modeling and Site-Directed Mutagenesis†

Biochemistry ◽  
1996 ◽  
Vol 35 (40) ◽  
pp. 13157-13164 ◽  
Author(s):  
Chenbo Zeng ◽  
Alexander E. Aleshin ◽  
Jason B. Hardie ◽  
Robert W. Harrison ◽  
Herbert J. Fromm
Keyword(s):  
Molecular Modeling ◽  
Human Brain ◽  
Binding Site ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Atp Binding ◽  
Atp Binding Site

Structural Features of the Glutamate Binding Site in Recombinant NR1/NR2A N-Methyl-d-aspartate Receptors Determined by Site-Directed Mutagenesis and Molecular Modeling

2005 ◽  
Vol 67 (5) ◽  
pp. 1470-1484 ◽  
Author(s):  
Philip E. Chen ◽  
Matthew T. Geballe ◽  
Phillip J. Stansfeld ◽  
Alexander R. Johnston ◽  
Hongjie Yuan ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Binding Site ◽  
Structural Features ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Glutamate Binding

Crystal structures and functional studies clarify substrate selectivity and catalytic residues for the unique orphan enzyme N-acetyl-D-mannosamine dehydrogenase

2014 ◽  
Vol 462 (3) ◽  
pp. 499-511 ◽  
Author(s):  
Agustín Sola-Carvajal ◽  
Fernando Gil-Ortiz ◽  
Francisco García-Carmona ◽  
Vicente Rubio ◽  
Álvaro Sánchez-Ferrer
Keyword(s):  
Substrate Specificity ◽  
Crystal Structures ◽  
Functional Site ◽  
Site Directed Mutagenesis ◽  
Short Chain ◽  
Directed Mutagenesis ◽  
Substrate Selectivity ◽  
Functional Studies ◽  
Short Chain Dehydrogenase ◽  
Orphan Enzyme

Functional site-directed mutagenesis and crystallographic studies with N-acetyl-D-mannosamine dehydrogenase reveal a homotetramer, a short-chain dehydrogenase/reductase subunit fold and a highly developed C-terminal tail interlinking subunit. The structures of the complexes explain substrate specificity. The four residues forming the catalytic tetrad are identified.

Molecular Modeling and Site-Directed Mutagenesis Studies of a Phorbol Ester-Binding Site in Protein Kinase C

1996 ◽  
Vol 39 (13) ◽  
pp. 2541-2553 ◽  
Author(s):  
Shaomeng Wang ◽  
Marcelo G. Kazanietz ◽  
Peter M. Blumberg ◽  
Victor E. Marquez ◽  
G. W. A. Milne
Keyword(s):  
Protein Kinase C ◽  
Molecular Modeling ◽  
Protein Kinase ◽  
Binding Site ◽  
Phorbol Ester ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Kinase C

scholarly journals Exploration of the ligand binding site of the human 5-HT4 receptor by site-directed mutagenesis and molecular modeling

2000 ◽  
Vol 130 (3) ◽  
pp. 527-538 ◽  
Author(s):  
Jeanne Mialet ◽  
Yamina Dahmoune ◽  
Frank Lezoualc'h ◽  
Isabelle Berque-Bestel ◽  
Pierre Eftekhari ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Ligand Binding ◽  
Binding Site ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Ligand Binding Site

The ligand binding site of NPY at the rat Y1 receptor investigated by site-directed mutagenesis and molecular modeling

1998 ◽  
Vol 139 (1-2) ◽  
pp. 187-198 ◽  
Author(s):  
Catherine Robin-Jagerschmidt ◽  
Ingebrigt Sylte ◽  
Claire Bihoreau ◽  
Luce Hendricksen ◽  
Alain Calvet ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Ligand Binding ◽  
Binding Site ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Ligand Binding Site ◽  
Y1 Receptor
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