scholarly journals Localization of Members of the γ-Glutamyl Transpeptidase Family Identifies Sites of Glutathione and Glutathione S-Conjugate Hydrolysis

2007 ◽  
Vol 144 (4) ◽  
pp. 1715-1732 ◽  
Author(s):  
Melinda N. Martin ◽  
Pilar H. Saladores ◽  
Elton Lambert ◽  
Andre O. Hudson ◽  
Thomas Leustek
Keyword(s):  
Glutamyl Transpeptidase ◽  
Conjugate Hydrolysis

Serum γ-Glutamyl Transpeptidase Activity in Liver Disease

1961 ◽  
Vol 41 (4) ◽  
pp. 353-359 ◽  
Author(s):  
Edward Szczeklik ◽  
Marian Orlowski ◽  
Apolinary Szewczuk
Keyword(s):  
Liver Disease ◽  
Glutamyl Transpeptidase

Serum γ-Glutamyl Transpeptidase Activity In Hepatobiliary Pancreatic Disease

1963 ◽  
Vol 45 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Alexander M. Rutenburg ◽  
Julius A. Goldbarg ◽  
Esteban P. Pineda
Keyword(s):  
Pancreatic Disease ◽  
Glutamyl Transpeptidase

Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus

2018 ◽  
Vol 69 (3) ◽  
pp. 739-743 ◽  
Author(s):  
Madalina Irina Mitran ◽  
Ilinca Nicolae ◽  
Corina Daniela Ene ◽  
Cristina Iulia Mitran ◽  
Clara Matei ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Lichen Planus ◽  
Inflammatory Process ◽  
Molecular Mechanisms ◽  
Functional Adaptation ◽  
Physical Factors ◽  
Inflammatory Disorder ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Glutamyl Transpeptidase

Chemicals used in the manufacture of synthetic fibers have been associated with undesirable side effects such as itching or skin lesions and it seems that they are involved in the induction of pathological processes such as oxidative stress and inflammation. Lichen planus (LP) can be regarded as an inflammatory disorder, chemical and physical factors playing an important role in the perpetuation of the inflammatory process. Gamma-glutamyl transpeptidase (GGT) plays an important role in the preservation of skin architecture and modulation of skin inflammation. In this study, we found that GGT activity is increased in LP patients with mild inflammation, whilst GGT is inactivated under conditions of severe inflammation. Therefore, GGT is involved in the inflammatory process, but there is no a positive correlation between its activity and the intensity of the inflammatory response. This functional adaptation of the enzyme may be due to down-regulation of its synthesis under free radical overload conditions. Understanding the molecular mechanisms involved in the modulation of intracellular redox homeostasis is an important step in the pharmacological management of patients with LP.

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